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Are Some Patients<br />
Harmed by Antipsychotics?<br />
• Subjects: 7-year follow-up of 128 subjects, 103 agreed<br />
to participate<br />
• Following initial remission, half randomized to dose<br />
reduction, half to maintenance treatment<br />
• ~10% on typical antipsychotic<br />
• Outcomes<br />
• DR group had less overall exposure to<br />
antipsychotics<br />
• Relapse rates similar, most patients in both groups<br />
had trial off of antipsychotic<br />
• Symptom remission at 7 years similar in both<br />
groups<br />
• Functional remission* 46% DR vs 20% MT (P=.01)<br />
• Full recovery 40% DR vs 18% MT (P=.004)<br />
• 8 DR and 3 MT did not relapse after stopping<br />
antipsychotics<br />
Wunderink L, et al. JAMA Psychiatry. 2013 Sep;70(9):913-20.<br />
Cumulative Survival<br />
0.9<br />
0.6<br />
0.3<br />
0<br />
DR MT<br />
500 Days 3000 Days<br />
Time to Relapse from t6, d<br />
*Groningen Social Disability Schedule
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