Cu_Zn_Organometallics
its all about organometallic chemistry of zinc and copper metal
its all about organometallic chemistry of zinc and copper metal
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Reaction of Organozinc compounds<br />
The Reformatsky Reaction<br />
• Important: conversion of β-hydroxy esters to α,β-unsat. esters<br />
• Acid-cat. dehydration gives α,β- + β,γ-unsaturated esters mixture<br />
• However, conversion of the initially formed β-hydroxy esters to<br />
their corresponding acetates by treatment with acetyl chloride,<br />
followed by base-catalyzed dehydration with NaOEt, produces<br />
conjugated esters in high purity.
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