Cu_Zn_Organometallics

Reaction of Organozinc compounds
Cyclopropanation
• characteristics:
– stereospecificity (retention of olefin geometry);
– tolerance of a variety of functional groups, such as Cl, Br,
OH, OR, CO 2 R, C=O, and CN;
– the syn-directing effect of hydroxyl and ether functions;
– chemoselectivity—zinc carbenoids are electrophilic and
react chemoselectively with the more nucleophilic double
bond in dienes and polyenes.