Psychiatrie - Sekce poruchy příjmu potravy

30
Abstrakta
nistrovány elektronicky prostřednictvím softwaru
Web-Akquasi vyvinutého Centrem pro
výzkum v psychoterapii Univerzity Heidelberg.
Design studie znázorňuje tabulka 1.
Výsledky: V našem sdělení prezentujeme
první výsledky studie se zaměřením na neuropsychologické
charakteristicky pacientů
(srovnání visuoprostorové organizace a paměti
a centrální koherence na začátku a na konci
hospitalizace a mezi pacientkami s mentální
anorexií, bulimií a zdravými kontrolami).
Podpořeno VZ 21620816 a projektem INTACT
(MRTN-CT-2006-035988)
Literatura
1. Bauer S, Winn S, Schmidt U, Kordy H. Construction, scoring
and validation of the Short Evaluation of Eating Disorders
(SEED), European Eating Disorders Review. 2005; 13:
191–200.
2. Claes L, Vandereycken W. The Self-Injury Questionnaire-
Treatment Related (SIQ-TR): Construction, reliability, and validity
in a sample of female eating disorder patients. In P.M. Goldfarb
(Ed.), Psychological Tests and Testing Research Trends,
111–139, New York: Nova Science Publishers.
3. Cloninger CR. A systematic Metod for clinical description
and classifi cation of personality variants. A proposal. Arch
Gen Psychiatry. 1987; 44(6): 537–588.
4. Fairburn CG, Beglin SJ. Assessment of eating disorders: interview
or self-report questionnaire? Int J Eat Disord. 1994;
16(4): 363–370.
5. Goodman WK, Price LH, Rasmusse SA, Mazure C,
Fleischmann RL, Hill CL, Heninger GR, Charney DS. The Yale-
Brown Obsessive Compulsive Scale, I., Developmenrt, use
and reliability. Arch Gen Psychiatry. 1989; 46(11).
6. Lopez C, Tchanturia K, Stahl D, Booth R, Holliday J, Treasure
J. An Examination of the Concept of Central Coherence
in Women with Anorexia Nervosa. Int J Eat Disord. 2008;
41(2): 143–152.
7. Moessner M, Bauer S, Fassnacht D, Kordy H. Construction
and Validation of the Clinical and Research Inventory for Eating
Disorders (CR-EAT). Manuscript in preparation.
8. Osterrieth PA. Le test de copie d´une fi gure complex: Contribution
a l´etude de la perception et de la memoire. Archives
de Psychologie. 1944; 30: 286–356.
9. Rieger E, Touyz SW, Beumont PJ. The Anorexia Nervosa
Stages of Change Questionnaire (ANSOCQ): Information
Regarding its Psychometric Properties. Int J Eat Disord.
2002; 32(1): 24–38.
Proteiny tukové tkáně
a inzulinová senzitivita
Insulin sensitivity
and proteins of the fat tissue
Horáková D., Kollárová H., Pastucha D.,
Janoutová G., Janout V.
Ústav preventivního lékařství LF UP,
Olomouc. Department of Preventive Medicine
Faculty of Medicine, Palacky University,
Olomouc
Souhrn: Inzulinová rezistence je velmi sledovaným
jevem v patogeneze metabolického
syndromu. Podílí se na rozvoji diabetu 2. typu,
obezity, hytertenze, akceleruje aterosklerózu. Je
Tabulka. Design Studie
Začátek hospitalizace
Monitoring
á 7 dnů
studována aktivita tukové tkáně, která je zdrojem
proteinů adiponektinu a aFABP, ovlivňujících
senzitivitu cílových tkání na inzulin. Na souboru
pacientů s projevy inzulinové rezistence a skupině
zdravých jedinců byly měřeny koncentrace
adiponektinu a aFABP a stanoveny korelace
s ostatními metabolickými parametry, včetně
homeostatických indexů. Závěry ukazují, že
adiponektin může být vhodným biomarkerem
stavu inzulinové senzitivity v organizmu.
Summary: Concentrations of adiponectine
and aFABP were measured in a group of patients
with insuline resistency and healthy controls.
Correlations with other metabolic parameters including
other homeostatic indices were calculated. The
results show that adiponectine can be a biomarker
of insulin sensitivity.
Biomarkers of Anorexia Nervosa
Biologické markery anorexia nervosa
Sietske G. Helder, Ricardo Sainz-Fuertes, Frederique
Van den Eynde, Anna V. Oldershaw,
Janet Treasure, Iain C. Campbell, Simon Lovestone,
Ulrike H. Schmidt, David A. Collier
Social, Genetic and Developmental Psychiatry
Research Centre, Eating Disorders
Section, MRC Centre for Neurodegeneration
Research, Institute of Psychiatry, King’s
College London, London, UK
Anorexia Nervosa (AN) is characterized by
below normal weight and persistent fear of
weight gain, as well as obsessive-compulsive,
harm-avoidant and anxious traits. It has high
levels of mortality and disability and early
identification of high risk cases is crucial to
prevent these negative outcomes. There is
also a need to better understand causal and
maintaining factors of all subtypes of AN, in
order to improve and tailor treatment. There
is growing evidence that altered neurobiology
significantly contributes to the pathogenesis
of AN. Gene association, candidate protein and
neuroimaging studies have already pointed
Konec hospitalizace
VII. Mezioborová konference o poruchách příjmu potravy a obezitě s mezinárodní účastí | 19. – 21. 3. 2009
Follow-up
á 1 měsíc
Follow-up po
6 měsících
Poslední follow-up
(6–18
měsíců)
EDE-Q (symptomy PPP) X X X X X X
SEED (symptomy PPP) X X X X X X
CR-EAT (symptomy PPP) X X X X X X
Y-BOCS (OCD symptomy) X X X X
SIQ-TR (sebezraňování) X X X X X X
ANSOCQ (motivace k léčbě) X X X X
RCFT (prostorová paměť a organizace) X X
TPQ (osobnost) X
out systems that may be involved in AN, such
as serotonin and dopamine. But because most
methods tend to only look at one molecule at
a time, there is still little understanding of the
complexity and interactions of the systems.
We conducted a proteome-wide analysis of
AN, aimed at identifying new protein biomarkers
of the disease. Biomarkers are useful in
aetiological studies and have potential for
translation to clinical management of patients.
Once validated, they can be used to monitor
disease course and severity, to tailor treatment
or to predict onset, relapse, treatment
response or outcome.
We will present an overview of the first
results of a pilot study comparing current
AN patients to recovered AN patients and
healthy controls. Blood plasma was analyzed
by two-dimensional gel electrophoresis, using
methods that have proved useful in proteomic
studies of Alzheimer’s disease. We are
following up these results in a longitudinal
case-only study.
Supported by INTACT (MRTN-CT-2006-035988)
Genotypes and phenotypes in
anorexia nervosa
Genotypy a fenotypy u anorexia nervosa
Marek Brandys, Judith Hendriks, Unna Danner,
Annemarie van Elburg, Roger Adan
Rudolf Magnus
Institute of Neuroscience, Dept. of Neuroscience
and Pharmacology, University
Medical Center Utrecht, The Netherlands,
Rintveld Centre for Eating Disorders, Altrecht
Mental Health Institute, Zeist, The Netherlands,
Dept. of Clinical & Health Psychology,
Utrecht University, The Netherlands
Anorexia nervosa (AN) is a psychiatric disease
with a well-documented heritability. The mechanisms
of genetic susceptibility to AN remain largely
unknown. In this study we begin with determining
associations of candidate genes to the disease