Floor plan - 2013 Annual Meeting - American Association for Hand ...

Comparative Analysis of Holding Strength of Available ìNerve Gluesî
Institution where the work was prepared: Candice McDaniel, Richmond, VA, USA
Jonathan Isaacs, MD1; Candice O. McDaniel, MD2; John R. Owen, PE3; Jennifer S. Wayne3; (1)VCU Medical Center,
(2)Medical College of Virginia at VCUHS, (3)Virginia Commonwealth University
HYPOTHESIS:
A variety of potentially useful artificial and biological sealants applied to a sutured nerve decrease gapping at the repair site.
METHODS:
Fifty-seven cadaveric nerve specimens were transected and repaired with two 8-0 nylon epineural sutures placed 180 degrees apart.
The specimens were divided into five groups. Four groups received augmentation of the repair with application of either autologous
fibrin glue, Tisseel fibrin glue (Baxter Healthcare Corporation), Evicel fibrin glue (Ethicon, Inc.), or DuraSeal polyethylene glycol based
hydrogel sealant (Confluent Surgical, Inc.). Each nerve construct was mounted in a servohydraulic materials testing machine (Instron
Corporation; MTS Systems Corporation) and stretched at a constant 5mm/min displacement rate until failure. A noncontact video analysis
permitted normalization of stretch within the repair region. Statistical analysis was performed via ANOVA followed by Tukey-Kramer
post-hoc pairwise comparison, if indicated.
RESULTS:
There was no statistical difference for the peak load at failure between any of the groups (p>0.4, Fig. 1). Resistance to gapping as measured
through normalized stiffness (N/mm/mm) was greater for the Tisseel group (p