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Does the Ischemia Time Affect the Outcome of Free Fibula Flaps <strong>for</strong> Head and Neck<br />

Reconstruction? A Review of 117 Fibular Flaps<br />

Institution where the work was prepared: Chang Gung Memorial Hospital, Tao-yuan, Taipeh, Taiwan<br />

Shu-ying Chang, MD; Huang-Kai Kao, MD; Jung-Ju Huang, MD; Holger Engel, MD; Betul Ulusal; Ming-Huei Cheng,<br />

MD, PhD; Chang Gung Memorial Hospital<br />

INTRODUCTION:<br />

Fibula osteocutaneous flap is a good option <strong>for</strong> reconstruction of segmental mandibular defect. The ischemia time of fibula flap <strong>for</strong><br />

mandibular reconstruction is variable according to surgeon's experiences, osteotomies of fibula and fixation of fibula be<strong>for</strong>e vs. after<br />

division of the pedicle, anastomosis be<strong>for</strong>e vs. after inset of the flap, and artery vs. vein anastomosis first. The purposes of this study<br />

were to investigate the relations between the ischemia time and the outcome of fibula flap including bone and skin paddle, and to<br />

establish the upper limit of ischemia time <strong>for</strong> fibula flap.<br />

MATERIALS/METHODS:<br />

Between February of 2003 and March of 2005, 117 fibula flaps were used <strong>for</strong> mandibular reconstructions. The outcome was compared<br />

in the success rate and the complication rate among different ischemia time, 1~3 (n=29), 3~4 (n=51), 4~5 (n=23), 5~7(n=14) hours<br />

groups. The complications were defined as three categories: acute complications (within a week postoperatively); subacute complications<br />

(between a week and one month postoperatively); and chronic complications (one month after operation).<br />

RESULTS:<br />

The mean ischemia time was 3.6 hours (ranged from 1 to 6.6 hours). The patient's risk factors including smoking, diabetes, pre-operative<br />

radiotherapy, and cancer stage were not statistically different between each group. The re-exploration rate was 7.7%. Mean flap success<br />

rate was 98.3%. Mean partial flap loss rate was 17.1% (ranged from 7.8 to 100 %). There was statistical difference between the ischemia<br />

time shorter and longer than 5 hours groups (P=0.035). There was no statistically significant difference among the 4 groups in success<br />

rate and complication rates in different stages. The number of osteotomies (0~3) of fibula bone did not significantly affect the success<br />

rate, complication (acute, subacute, chronic and overall complications ) rates, partial flap loss rate, and bone loss rate in this series.<br />

DISCUSSION:<br />

Although the ischemia time of fibula flap is critical <strong>for</strong> the microsurgical mandibular reconstruction, surgeons may spend a little more<br />

time <strong>for</strong> shaping the fibula to mandible or even adding the osseointegrated dental im<strong>plan</strong>ts if the longer ischemia time does not compromise<br />

the outcome of this procedure. In conclusion, the longer ischemia time of fibula flap <strong>for</strong> mandibular reconstruction does not<br />

affect the success and complication rates. We suggest the ischemia time of fibula osteocutaneous flap <strong>for</strong> mandibular reconstruction<br />

is better limited to 5 hours to reduce the partial flap loss.<br />

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