1- Haemostatic Mechanism3

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This attachment signals for production of new TPO.TPO increases the number and rate of maturation of megakaryocytesvia c‐MPL receptor.Platelet levels start to rise 6 days after the start of therapy. AlthoughTPO itself is not available for clinical use, thrombomimetic agentswhich bind to c‐MPL are now used clinically to increase the plateletcount.
The normal platelet count is approximately 250 × 10 9 /L (range150–400 × 10 9 /L) and the normal platelet lifespan is 10 days. Thisis determined by the ratio of the apoptotic BAX and anti‐apoptoticBCL‐2 proteins in the cell.
Page 1 and 2: The Platelets, BloodCoagulation and
Page 3 and 4: The haemostatic system represents a
Page 5 and 6: Platelets
Page 7 and 8: Megakaryocytes: (a) immature form w
Page 9: Thrombopoietin (TPO)is the major re
Page 14 and 15: ➢The binding site for IIb/IIIa is
Page 16 and 17: ➢During the release reaction, the
Page 18: Von Willebrand factor (VWF)VWF is i
Page 21 and 22: Platelet aggregationThis is charact
Page 23 and 24: 2- Thromboxane A2 (TXA2) is importa
Page 25 and 26: Growth factorPDGF found in the α g
Page 27 and 28: ➢The operation of this (the coagu
Page 29 and 30: The coagulation factors.
Page 31 and 32: InitiationCoagulation is initiated
Page 34 and 35: Endothelial cellsThe endothelial ce
Page 36 and 37: VasoconstrictionImmediate vasoconst
Page 38 and 39: activates factor XI and XIII and co
Page 40 and 41: Coagulation factor inhibitorsIt is
Page 43 and 44: The action of protein C is enhanced

1- Haemostatic Mechanism3

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