1- Haemostatic Mechanism3

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The stored VWF can raise the plasma levels when released underthe influence of stress, exercise, adrenaline and infusion ofdesmopressin (1‐diamino‐8‐D‐arginine vasopressin; DDAVP).The VWF released from Weibel–Palade bodies is in the form oflarge and ultra‐large multimers, the most adhesive and reactive formof VWF. They are in turn cleaved in plasma to smaller multimersand monomeric VWF by the specific plasma metalloprotease.
Platelet aggregationThis is characterized by cross‐linking of platelets through activeGPIIb/IIIa receptors with fibrinogen bridges. A resting platelet hasGPIIb/IIIa receptors which do not bind fibrinogen, VWF or otherligands. Stimulation of a platelet leads to an increase in GPIIb/IIIamolecules, enabling platelet cross‐linking via VWF and fibrinogenbridges.
Page 1 and 2: The Platelets, BloodCoagulation and
Page 3 and 4: The haemostatic system represents a
Page 5 and 6: Platelets
Page 7 and 8: Megakaryocytes: (a) immature form w
Page 9 and 10: Thrombopoietin (TPO)is the major re
Page 11 and 12: The normal platelet count is approx
Page 14 and 15: ➢The binding site for IIb/IIIa is
Page 16 and 17: ➢During the release reaction, the
Page 18: Von Willebrand factor (VWF)VWF is i
Page 23 and 24: 2- Thromboxane A2 (TXA2) is importa
Page 25 and 26: Growth factorPDGF found in the α g
Page 27 and 28: ➢The operation of this (the coagu
Page 29 and 30: The coagulation factors.
Page 31 and 32: InitiationCoagulation is initiated
Page 34 and 35: Endothelial cellsThe endothelial ce
Page 36 and 37: VasoconstrictionImmediate vasoconst
Page 38 and 39: activates factor XI and XIII and co
Page 40 and 41: Coagulation factor inhibitorsIt is
Page 43 and 44: The action of protein C is enhanced

1- Haemostatic Mechanism3

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