1- Haemostatic Mechanism3
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Coagulation factor inhibitors
It is important that the effect of thrombin is limited to the site of
injury.
1- The first inhibitor to act is TFPI, which is synthesized in
endothelial cells and is present in plasma and platelets and
accumulates at the site of injury caused by local platelet activation.
TFPI inhibits Xa and VIIa and tissue factor to limit the main in vivo
pathway.
2- There is also direct inactivation of thrombin and other serine
protease factors by antithrombin, Heparin and heparin cofactor II,
also inhibits thrombin.
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