1- Haemostatic Mechanism3
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activates factor XI and XIII and cofactors V and VIII.
The fibrin component of the haemostatic plug increases as the
fused platelets completely degranulate and autolyse, and after a
few hours the entire haemostatic plug is transformed into a solid
mass of crosslinked fibrin.
because of incorporation of plasminogen (tissue plasminogen
activator TPA)which is produced by endothelial cells, this plug
begins to autodigest during the same time frame (activate
fibrinolysis).