1- Haemostatic Mechanism3
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number of nuclear lobes increases. Early on invaginations of plasma
membrane are seen, called the demarcation membrane, which
evolves through the development of the megakaryocyte into a
highly branched network. At a variable stage in development the
cytoplasm becomes granular.
Mature megakaryocytes are extremely large, with an eccentrically
placed single lobulated nucleus and a low nuclear : cytoplasmic
ratio. Platelets form by fragmentation from the tips of cytoplasmic
extensions of megakaryocyte cytoplasm
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