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1- Haemostatic Mechanism3

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Blood coagulation

The coagulation cascade:

The coagulation cascade of secondary hemostasis has two initial

pathways which lead to fibrin formation. These are the contact

activation pathway (also known as the intrinsic pathway), and the

tissue factor pathway (also known as the extrinsic pathway), which

both lead to the same fundamental reactions that produce fibrin. It

was previously thought that the two pathways of coagulation

cascade were of equal importance, but it is now known that the

primary pathway for the initiation of blood coagulation is the tissue

factor (extrinsic) pathway.

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