1- Haemostatic Mechanism3
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Blood coagulation
The coagulation cascade:
The coagulation cascade of secondary hemostasis has two initial
pathways which lead to fibrin formation. These are the contact
activation pathway (also known as the intrinsic pathway), and the
tissue factor pathway (also known as the extrinsic pathway), which
both lead to the same fundamental reactions that produce fibrin. It
was previously thought that the two pathways of coagulation
cascade were of equal importance, but it is now known that the
primary pathway for the initiation of blood coagulation is the tissue
factor (extrinsic) pathway.