1- Haemostatic Mechanism3
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➢The operation of this (the coagulation factors) enzyme cascade
requires local concentration of circulating coagulation factors at the
site of the injury.
➢reactions occur on exposed collagen, platelet phospholipid and
tissue factor.
➢With the exception of fibrinogen, which is the fibrin clot subunit,
the coagulation factors are either enzyme precursors or cofactors
(Table 24.1).
All the enzymes, except factor XIII, are serine proteases. The scale
of amplification achieved in this system is dramatic.
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