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1- Haemostatic Mechanism3

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The action of protein C is enhanced by another vitamin K‐

dependent protein S, which binds protein C to the platelet surface

(Fig. 24.13). Also protein C bind to its receptor on the endothelial

surface, promoting protein C activation by the thrombin–

thrombomodulin complex.

In addition, activated protein C enhances fibrinolysis (Fig. 24.13).

like other serine proteases, activated protein C is inactivated by

serum protease inactivators (serpins), e.g. antithrombin.

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