and HBeAg(-) patients - World Journal of Gastroenterology

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Giles GG, Limburg P, Newcomb P, Young JP, Walsh MD, Thibodeau SN, Lindor NM, Lemarchand L, Gallinger S, Haile RW, Potter JD, Hopper JL, Jass JR. Pathology features in Bethesda guidelines predict colorectal cancer microsatellite instability: a population-based study. Gastroenterology 2007; 133: 48-56 39 Truta B, Chen YY, Blanco AM, Deng G, Conrad PG, Kim YH, Park ET, Kakar S, Kim YS, Velayos F, Sleisenger MH, Terdiman JP. Tumor histology helps to identify Lynch syndrome among colorectal cancer patients. Fam Cancer 2008; 7: 267-274 40 Wright CL, Stewart ID. Histopathology and mismatch repair status of 458 consecutive colorectal carcinomas. Am J Surg Pathol 2003; 27: 1393-1406 41 Jass JR. HNPCC and sporadic MSI-H colorectal cancer: a review of the morphological similarities and differences. Fam Cancer 2004; 3: 93-100 42 Burgart LJ. Testing for defective DNA mismatch repair in colorectal carcinoma: a practical guide. Arch Pathol Lab Med 2005; 129: 1385-1389 43 Kakar S, Aksoy S, Burgart LJ, Smyrk TC. Mucinous carcinoma of the colon: correlation of loss of mismatch repair WJG|www.wjgnet.com Koehler-Santos P et al . Identification of Lynch syndrome patients enzymes with clinicopathologic features and survival. Mod Pathol 2004; 17: 696-700 44 Lindor NM, Rabe K, Petersen GM, Haile R, Casey G, Baron J, Gallinger S, Bapat B, Aronson M, Hopper J, Jass J, LeMarchand L, Grove J, Potter J, Newcomb P, Terdiman JP, Conrad P, Moslein G, Goldberg R, Ziogas A, Anton-Culver H, de Andrade M, Siegmund K, Thibodeau SN, Boardman LA, Seminara D. Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X. JAMA 2005; 293: 1979-1985 45 Abdel-Rahman WM, Ollikainen M, Kariola R, Järvinen HJ, Mecklin JP, Nyström-Lahti M, Knuutila S, Peltomäki P. Comprehensive characterization of HNPCC-related colorectal cancers reveals striking molecular features in families with no germline mismatch repair gene mutations. Oncogene 2005; 24: 1542-1551 46 Piñol V, Castells A, Andreu M, Castellví-Bel S, Alenda C, Llor X, Xicola RM, Rodríguez-Moranta F, Payá A, Jover R, Bessa X. Accuracy of revised Bethesda guidelines, microsatellite instability, and immunohistochemistry for the identification of patients with hereditary nonpolyposis colorectal cancer. JAMA 2005; 293: 1986-1994 S- Editor Wang JL L- Editor Logan S E- Editor Ma WH 773 February 14, 2011|Volume 17|Issue 6|
Online Submissions: http://www.wjgnet.com/1007-9327office wjg@wjgnet.com doi:10.3748/wjg.v17.i6.774 BRIEF ARTICLE Single center experience of capsule endoscopy in patients with obscure gastrointestinal bleeding Mahesh Kumar Goenka, Shounak Majumder, Sanjeev Kumar, Pradeepta Kumar Sethy, Usha Goenka Mahesh Kumar Goenka, Shounak Majumder, Sanjeev Kumar, Pradeepta Kumar Sethy, Usha Goenka, Institute of Gastroenterology, Apollo Gleneagles Hospital, 58 Canal Circular Road, Kolkata-700054, India Author contributions: Goenka MK and Majumder S were the major contributors to this work; Goenka MK and Majumder S designed the research; Goenka MK interpreted all capsule endoscopy images; Majumder S was responsible for tabulating and analyzing the data, drafting the manuscript, and processing the images; Goenka MK and Majumder S wrote the article; Kumar S, Sethy PK and Goenka U performed a critical scientific review of the article and provided valuable input for modifying parts of the article prior to submission. Correspondence to: Dr. Mahesh Kumar Goenka, Institute of Gastroenterology, Apollo Gleneagles Hospital, 58 Canal Circular Road, Kolkata-700054, India. mkgkolkata@gmail.com Telephone: +91-33-22820636 Fax: +91-33-23205218 Received: August 5, 2010 Revised: September 13, 2010 Accepted: September 20, 2010 Published online: February 14, 2011 Abstract AIM: To identify optimum timing to maximize diagnostic yield by capsule endoscopy (CE) in patients with obscure gastrointestinal bleeding (OGIB). METHODS: We identified patients who underwent CE at our institution from August 2003 to December 2009. Patient medical records were reviewed to determine type of OGIB (occult, overt), CE results and complications, and timing of CE with respect to onset of bleeding. RESULTS: Out of 385 patients investigated for OGIB, 284 (74%) had some lesion detected by CE. In 222 patients (58%), definite lesions were detected that could unequivocally explain OGIB. Small bowel ulcer/erosions secondary to Crohn’s disease, tuberculosis or non-steroidal anti-inflammatory agent use were the commonest lesions detected. Patients with overt GI bleeding for < 48 h before CE had the highest diagnostic yield (87%). This was significantly greater (P < 0.05) compared to WJG|www.wjgnet.com 774 World J Gastroenterol 2011 February 14; 17(6): 774-778 ISSN 1007-9327 (print) ISSN 2219-2840 (online) © 2011 Baishideng. All rights reserved. that in patients with overt bleeding prior to 48 h (68%), as well as those with occult OGIB (59%). CONCLUSION: We established the importance of early CE in management of OGIB. CE within 48 h of overt bleeding has the greatest potential for lesion detection. © 2011 Baishideng. All rights reserved. Key words: Capsule endoscopy; Gastrointestinal bleeding Peer reviewer: Andrew Ukleja, MD, Assistant Professor, Clinical Assistant Professor of Medicine, Director of Nutrition Support Team, Director of Esophageal Motility Laboratory, Cleveland Clinic Florida, Department of Gastroenterology, 2950 Cleveland Clinic Blvd., Weston, FL 33331, United States Goenka MK, Majumder S, Kumar S, Sethy PK, Goenka U. Single center experience of capsule endoscopy in patients with obscure gastrointestinal bleeding. World J Gastroenterol 2011; 17(6): 774-778 Available from: URL: http://www.wjgnet.com/1007-9327/full/v17/i6/774.htm DOI: http://dx.doi. org/10.3748/wjg.v17.i6.774 INTRODUCTION Obscure gastrointestinal bleeding (OGIB) is responsible for about 5% of all gastrointestinal (GI) bleeding [1] . Although it represents a small proportion of patients with GI bleeding, OGIB continues to be a challenge because of delay in diagnosis and consequent morbidity and mortality. In recent times, capsule endoscopy (CE) and deviceassisted enteroscopy have established their position in the management algorithm for OGIB, and have had a significant impact on the outcome. CE is superior to push enteroscopy [2,3] , small bowel follow-through [4] and computed tomography (CT) [5] for detection of the bleeding source in the small bowel. There is however concern about sensitivity of CE in the setting of ongoing GI bleeding, due to possible visualization of blood limiting the interpretation. February 14, 2011|Volume 17|Issue 6|
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Robert JL Fraser, Daw Park Jacob Ge
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Italy Donato F Altomare, Bari Piero
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S Contents EDITORIAL REVIEW ORIGINA
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Contents ACKNOWLEDGMENTS APPENDIX A
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Jahn KA et al . Colon cancer and li
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Săftoiu A. Imaging techniques in E
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Ghimire P et al . Primary GI lympho
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Table 2 Comparison of hepatitis B e
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Utama A et al . HBV core promoter m
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Utama A et al . HBV core promoter m
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Motoki T et al . Glutamine depletio
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Table 2 Nutrient composition of mou
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