and HBeAg(-) patients - World Journal of Gastroenterology

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model of biliary atresia. J Virol 2007; 81: 1671-1679 21 Szavay PO, Leonhardt J, Czech-Schmidt G, Petersen C. The role of reovirus type 3 infection in an established murine model for biliary atresia. Eur J Pediatr Surg 2002; 12: 248-250 22 Shivakumar P, Sabla G, Mohanty S, McNeal M, Ward R, Stringer K, Caldwell C, Chougnet C, Bezerra JA. Effector role of neonatal hepatic CD8+ lymphocytes in epithelial injury and autoimmunity in experimental biliary atresia. Gastroenterology 2007; 133: 268-277 23 Mack CL, Falta MT, Sullivan AK, Karrer F, Sokol RJ, Freed BM, Fontenot AP. Oligoclonal expansions of CD4+ and CD8+ T-cells in the target organ of patients with biliary atresia. Gastroenterology 2007; 133: 278-287 24 Serinet MO, Wildhaber BE, Broué P, Lachaux A, Sarles J, Jacquemin E, Gauthier F, Chardot C. Impact of age at Kasai operation on its results in late childhood and adolescence: a rational basis for biliary atresia screening. Pediatrics 2009; 123: 1280-1286 25 Wadhwani SI, Turmelle YP, Nagy R, Lowell J, Dillon P, Shepherd RW. Prolonged neonatal jaundice and the diagnosis of biliary atresia: a single-center analysis of trends in age at diagnosis and outcomes. Pediatrics 2008; 121: e1438-e1440 26 Davenport M, Puricelli V, Farrant P, Hadzic N, Mieli-Vergani G, Portmann B, Howard ER. The outcome of the older (> or =100 days) infant with biliary atresia. J Pediatr Surg 2004; 39: 575-581s 27 Altman RP, Buchmiller TL. The jaundiced infant: biliary atresia. In: Grosfeld JL, O'neill JA, Fonkalsrud EW, Coran AG, editors. Pediatric surgery. St. Louis: Mosby, 2006: 1603-1619 28 Kershenobich Stalnikowitz D, Weissbrod AB. Liver fibrosis and inflammation. A review. Ann Hepatol 2003; 2: 159-163 29 Erickson N, Mohanty SK, Shivakumar P, Sabla G, Chakraborty R, Bezerra JA. Temporal-spatial activation of apoptosis and epithelial injury in murine experimental biliary atresia. Hepatology 2008; 47: 1567-1577 30 Mack CL, Tucker RM, Sokol RJ, Karrer FM, Kotzin BL, Whitington PF, Miller SD. Biliary atresia is associated with CD4+ Th1 cell-mediated portal tract inflammation. Pediatr Res 2004; WJG|www.wjgnet.com Zhao R et al . Gene expression analysis in biliary atresia 56: 79-87 31 Mack CL, Tucker RM, Sokol RJ, Kotzin BL. Armed CD4+ Th1 effector cells and activated macrophages participate in bile duct injury in murine biliary atresia. Clin Immunol 2005; 115: 200-209 32 Osada M, Tolkacheva T, Li W, Chan TO, Tsichlis PN, Saez R, Kimmelman AC, Chan AM. Differential roles of Akt, Rac, and Ral in R-Ras-mediated cellular transformation, adhesion, and survival. Mol Cell Biol 1999; 19: 6333-6344 33 Muraji T, Hosaka N, Irie N, Yoshida M, Imai Y, Tanaka K, Takada Y, Sakamoto S, Haga H, Ikehara S. Maternal microchimerism in underlying pathogenesis of biliary atresia: quantification and phenotypes of maternal cells in the liver. Pediatrics 2008; 121: 517-521 34 Kinbara K, Goldfinger LE, Hansen M, Chou FL, Ginsberg MH. Ras GTPases: integrins' friends or foes? Nat Rev Mol Cell Biol 2003; 4: 767-776 35 Jafri M, Donnelly B, McNeal M, Ward R, Tiao G. MAPK signaling contributes to rotaviral-induced cholangiocyte injury and viral replication. Surgery 2007; 142: 192-201 36 Taylor AW. Modulation of regulatory T cell immunity by the neuropeptide alpha-melanocyte stimulating hormone. Cell Mol Biol (Noisy-le-grand) 2003; 49: 143-149 37 Taylor AW, Kitaichi N. The diminishment of experimental autoimmune encephalomyelitis (EAE) by neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH) therapy. Brain Behav Immun 2008; 22: 639-646 38 Ohana E, Yang D, Shcheynikov N, Muallem S. Diverse transport modes by the solute carrier 26 family of anion transporters. J Physiol 2009; 587: 2179-2185 39 Despars G, O'Neill TJ, O'Neill HC. Use of gene profiling to describe a niche for dendritic cell development. Immunol Cell Biol 2007; 85: 567-570 40 Tsukada S, Westwick JK, Ikejima K, Sato N, Rippe RA. SMAD and p38 MAPK signaling pathways independently regulate alpha1(I) collagen gene expression in unstimulated and transforming growth factor-beta-stimulated hepatic stellate cells. J Biol Chem 2005; 280: 10055-10064 S- Editor Sun H L- Editor Wang XL E- Editor Zheng XM 803 February 14, 2011|Volume 17|Issue 6|
Online Submissions: http://www.wjgnet.com/1007-9327office wjg@wjgnet.com doi:10.3748/wjg.v17.i6.804 HBV infection decreases risk of liver metastasis in patients with colorectal cancer: A cohort study Hai-Bo Qiu, Li-Yi Zhang, Zhao-Lei Zeng, Zhi-Qiang Wang, Hui-Yan Luo, Rajiv Prasad Keshari, Zhi-Wei Zhou, Rui-Hua Xu Hai-Bo Qiu, Zhao-Lei Zeng, Zhi-Qiang Wang, Hui-Yan Luo, Rajiv Prasad Keshari, Zhi-Wei Zhou, Rui-Hua Xu, State Key Laboratory of Oncology in South China, Guangzhou 510060, Guangdong Province, China Hai-Bo Qiu, Zhi-Qiang Wang, Hui-Yan Luo, Rui-Hua Xu, Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, Guangdong Province, China Hai-Bo Qiu, Rajiv Prasad Keshari, Zhi-Wei Zhou, Department of Gastric and Pancreatic Surgery, Sun Yat-Sen University Cancer Center, Guangzhou 510060, Guangdong Province, China Li-Yi Zhang, Department of Clinical Oncology, University of HongKong, Pokfulam, HongKong, China Zhao-Lei Zeng, Department of Research, Sun Yat-Sen University Cancer Center, Guangzhou 510060, Guangdong Province, China Author contributions: Qiu HB and Zhang LY contributed equally to this work; Qiu HB and Xu RH defined the research theme; Qiu HB, Zhang LY and Zeng ZL designed the methods and wrote the paper; Keshari RP revised the manuscript; Zhang LY, Wang ZQ and Luo HY analyzed the data and interpreted the results; Qiu HB and Zhou ZW collected, interpreted the data, and discussed the analyses; all authors approved the manuscript. Supported by National Natural Science Foundation of China, No. 30672408 Correspondence to: Rui-Hua Xu, MD, PhD, Professor of Medical Oncology, Vice President, Sun Yat-Sen University Cancer Center, Guangzhou 510060, Guangdong Province, China. xurh@sysucc.org.cn Telephone: +86-20-87343468 Fax: +86-20-87343228 Received: October 7, 2010 Revised: November 8, 2010 Accepted: November 15, 2010 Published online: February 14, 2011 Abstract AIM: To evaluate the effect of hepatitis B virus (HBV) infection on liver metastasis of colorectal cancer. METHODS: A total of 1298 colorectal cancer patients were recruited from January 2001 to March 2005 in this study. Enzyme-linked immunosorbent assay was used to WJG|www.wjgnet.com World J Gastroenterol 2011 February 14; 17(6): 804-808 ISSN 1007-9327 (print) ISSN 2219-2840 (online) © 2011 Baishideng. All rights reserved. test serum HBV markers for colorectal cancer. Patients were divided into study (infection) group and control (non-infection) group. Clinical features of patients in two groups were compared. RESULTS: Liver metastasis was found in 319 out of the 1298 colorectal cancer patients. The incidence of liver metastasis was significantly lower in study group than in control group (14.2% vs 28.2%, P < 0.01). HBV infection significantly decreased the risk of liver metastasis [hazard ratio (HR): 0.50, 95% confidence interval (95% CI): 0.38-0.66], but the incidence of extrahepatic metastasis was significantly higher in study group than in control group (31.9% vs 17.0%, P < 0.01). The HR was the lowest in chronic hepatitis B group (HR: 0.29, 95% CI: 0.12-0.72). The number of liver metastatic lesions was significantly less in study group than in control group with a higher surgical resection rate. However, no significant difference was found in survival rate between the two groups (P = 0.95). CONCLUSION: HBV infection decreases the risk of liver metastasis in patients with colorectal cancer and elevates the surgical resection rate of liver metastatic lesions. © 2011 Baishideng. All rights reserved. BRIEF ARTICLE Key words: Hepatitis B virus; Colorectal cancer; Liver metastasis; Risk Peer reviewers: Dr. Lucia Ricci Vitiani, Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena, 299, Rome 00161, Italy; Hitoshi Tsuda, MD, PhD, Diagnostic Pathology Section, Clinical Laboratory Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuoku, Tokyo 104-0045, Japan Qiu HB, Zhang LY, Zeng ZL, Wang ZQ, Luo HY, Keshari RP, Zhou ZW, Xu RH. HBV infection decreases risk of liver metastasis in patients with colorectal cancer: A cohort study. World 804 February 14, 2011|Volume 17|Issue 6|
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World Journal of Gastroenterology W
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Robert JL Fraser, Daw Park Jacob Ge
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Italy Donato F Altomare, Bari Piero
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Fernando Azpiroz, Barcelona Ramon B
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S Contents EDITORIAL REVIEW ORIGINA
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Contents ACKNOWLEDGMENTS APPENDIX A
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Jahn KA et al . Colon cancer and li
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Săftoiu A. Imaging techniques in E
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Ghimire P et al . Primary GI lympho
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Online Submissions: http://www.wjgn
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Table 2 Comparison of hepatitis B e
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Utama A et al . HBV core promoter m
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Utama A et al . HBV core promoter m
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Motoki T et al . Glutamine depletio
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Table 2 Nutrient composition of mou
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A Motoki T et al . Glutamine deplet
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A Counts B % of sub-G0 cell populat
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Motoki T et al . Glutamine depletio
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Hu JD et al . Urinary metabolomic p
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Abundance/× 10 6 Abundance/× 10 6
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A Regression factor scores 2 for an
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Hu JD et al . Urinary metabolomic p
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Fu JF et al . NAFLD and metabolic s
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developing hypertension (OR: 2.18,
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obese and exhibited higher insulin
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Roberts SE et al . Perinatal factor
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Roberts SE et al . Perinatal factor
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