and HBeAg(-) patients - World Journal of Gastroenterology

In conclusion, the EEA animal model of bile duct established
in this study can be used in studies of BDI etiology,
development, and possible prophylaxis, and provide
some valuable information for the postoperative healing
process of bile duct.
COMMENTS
Background
Treatment of bile duct injury (BDI) remains a great challenge for gastrointestinal
surgeons. No consensus has been reached concerning the ideal method for
bile duct reconstruction. No large scale clinical study is available on bile duct
reconstruction.
Research frontiers
Some surgeons prefer end-to-end anastomosis (EEA) as a more physiological
method in bile duct reconstruction. However, no large-scale clinical study or
suitable animal model is available or analyzed. In this study, by establishing a
reliable animal EEA model of common bile duct (CBD) and observing the postoperative
results of histological, immunohistochemical exanimation, serologic
and bile content analysis, as well as bile duct parameters, the authors demonstrated
that EEA can be utilized in treatment of BDI.
Innovations and breakthroughs
The authors provided a simple and reliable animal EEA model of CBD with a
good outcome in this study, which may shed light on studies of BDI etiology,
development, and possible prophylaxis.
Applications
The animal EEA model of CBD we established in the present study can be utilized
in studies on BDI etiology, development, and possible prophylaxis as well as
provide some valuable information for the post-operative healing process of EEA.
Terminology
EEA, an end-to-end anastomosis procedure, is a more preferable choice of
treatment than Roux-en-Y maneuver. MFB are the myofibroblasts with α-SMA
expression in stress fibers. In wound healing, inflammation mediators and mechanical
tension lead to generation of actin-containing microfilaments or stress
fibers which confer contractile property to fibroblasts, and convert them into
terminally differentiated MFB. MFB are the major constituent of inflammatory and
reparative granulation tissue and can last scar contraction and stricture formation.
Peer review
In this study, the animals gained their weight and no postoperative biliary obstruction
was observed in any group after bile duct reconstruction with EEA in this
study, showing that EEA is a simple and reliable procedure for bile duct reconstruction
with a satisfactory survival rate, which provides some valuable information
for the postoperative healing process of bile duct.
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S- Editor Tian L L- Editor Wang XL E- Editor Lin YP
795 February 14, 2011|Volume 17|Issue 6|