and HBeAg(-) patients - World Journal of Gastroenterology

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doi:10.3748/wjg.v17.i6.784
Higher parity associated with higher risk of death from
gastric cancer
Chih-Ching Chang, Chih-Cheng Chen, Hui-Fen Chiu, Chun-Yuh Yang
Chih-Ching Chang, Department of Environmental and Occupational
Health, National Cheng Kung University, Tainan 70154,
Taiwan, China
Chih-Cheng Chen, Department of Pediatrics, Chang-Gung Memorial
Hospital, Kaohsiung Medical Center, Chang-Gung University,
College of Medicine, Kaohsiung 80708, Taiwan, China
Hui-Fen Chiu, Department of Pharmacology, College of Medicine,
Kaohsiung Medical University, Kaohsiung 80708, Taiwan,
China
Chun-Yuh Yang, Faculty of Public Health, College of Health Sciences,
Kaohsiung Medical University, Kaohsiung 80708, Taiwan,
China
Chun-Yuh Yang, Division of Environmental Health and Occupational
Medicine, National Health Research Institute, Miaoli
36051, Taiwan, China
Author contributions: Chang CC did the statistical analysis and
wrote the manuscript; Chen CC and Chiu HF provided essential
insight into the interpretation of the results; Yang CY contributed
to the study design and interpretation of the data, He had full access
to all of the data in the study, and took responsibility for the
integrity of the data and the accuracy of the data analysis.
Supported by A grant from the National Science Council, Executive
Yuan, Taiwan, No. NSC-94-2314-B-037-056
Correspondence to: Chun-Yuh Yang, PhD, MPH, Faculty of
Public Health, Kaohsiung Medical University, 100 Shih-Chuan
1st RD, Kaohsiung 80708, Taiwan, China. chunyuh@kmu.edu.tw
Telephone: +886-7-3121101 Fax: +886-7-3110811
Received: October 14, 2010 Revised: December 27, 2010
Accepted: January 4, 2011
Published online: February 14, 2011
Abstract
AIM: To examine the association between parity and
gastric cancer (the cases are almost all premenopausal
women) risk in a cohort of young parous women.
METHODS: The study cohort consisted of all women
with a record of a first and singleton childbirth in the
Birth Register between 1978 and 1987. We tracked
each woman from the time of her first childbirth to December
31, 2008. Their vital status was ascertained by
linking records to the computerized mortality database.
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World J Gastroenterol 2011 February 14; 17(6): 784-788
ISSN 1007-9327 (print) ISSN 2219-2840 (online)
© 2011 Baishideng. All rights reserved.
Cox proportional hazard regression models were used
to estimate hazard ratios of death from gastric cancer
associated with parity.
RESULTS: There were 1090 gastric cancer deaths
(85.87% of them were premenopausal) during 33 686 828
person-years of follow-up. The mortality rate of gastric
cancer was 3.24 cases per 100 000 person-years. A trend
of increasing risk of gastric cancer was seen with increasing
parity. The adjusted hazard ratio was 1.24 [confidence
interval (95% CI): 1.02-1.50] for women who had borne
two to three children, and 1.32 (95% CI: 1.01-1.72) for
women with four or more births, when compared with
women who had given birth to only one child.
CONCLUSION: These results suggest that higher parity
may increase the risk of death from gastric cancer
among premenopausal women.
© 2011 Baishideng. All rights reserved.
BRIEF ARTICLE
Key words: Gastric cancer; Parity; Mortality; Cohort
study
Peer reviewer: Mitsuyoshi Urashima, MD, PhD, MPH, Division
of Molecular Epidemiology, Jikei University School of
Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo 105-8461,
Japan
Chang CC, Chen CC, Chiu HF, Yang CY. Higher parity associated
with higher risk of death from gastric cancer. World
J Gastroenterol 2011; 17(6): 784-788 Available from: URL:
http://www.wjgnet.com/1007-9327/full/v17/i6/784.htm DOI:
http://dx.doi.org/10.3748/wjg.v17.i6.784
INTRODUCTION
In Taiwan, gastric cancer (GC) is the fifth leading cause of
cancer mortality for males and females [1] . The age-adjusted
mortality rate for gastric cancer was 14.1 per 100 000
among males and 7.4 among females in 2007. There is
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