and HBeAg(-) patients - World Journal of Gastroenterology

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esophageal lymphoma: case series and review of the literature. Dig Dis Sci 2006; 51: 77-83 64 Stathis A, Chini C, Bertoni F, Proserpio I, Capella C, Mazzucchelli L, Pedrinis E, Cavalli F, Pinotti G, Zucca E. Long-term outcome following Helicobacter pylori eradication in a retrospective study of 105 patients with localized gastric marginal zone B-cell lymphoma of MALT type. Ann Oncol 2009; 20: 1086-1093 65 Park HS, Kim YJ, Yang WI, Suh CO, Lee YC. Treatment outcome of localized Helicobacter pylori-negative low-grade gastric MALT lymphoma. World J Gastroenterol 2010; 16: 2158-2162 66 Dickson BC, Serra S, Chetty R. Primary gastrointestinal tract lymphoma: diagnosis and management of common neoplasms. Expert Rev Anticancer Ther 2006; 6: 1609-1628 67 Witzig TE. Current treatment approaches for mantle-cell lymphoma. J Clin Oncol 2005; 23: 6409-6414 68 Ogura M. Current treatment strategy and new agents in mantle cell lymphoma. Int J Hematol 2010; 92: 25-32 69 Song KW, Barnett MJ, Gascoyne RD, Horsman DE, Forrest DL, Hogge DE, Lavoie JC, Nantel SH, Nevill TJ, Shepherd JD, Smith CA, Sutherland HJ, Voss NJ, Toze CL, Connors JM. Haematopoietic stem cell transplantation as primary therapy of sporadic adult Burkitt lymphoma. Br J Haematol 2006; 133: 634-637 70 Aleman BM, Haas RL, van der Maazen RW. Role of radiotherapy in the treatment of lymphomas of the gastrointestinal tract. Best Pract Res Clin Gastroenterol 2010; 24: 27-34 71 Ruskoné-Fourmestraux A, Dragosics B, Morgner A, Wotherspoon A, De Jong D. Paris staging system for primary gastrointestinal lymphomas. Gut 2003; 52: 912-913 72 Babel N, Paragi P, Chamberlain RS. Management of Enter- WJG|www.wjgnet.com Ghimire P et al . Primary GI lymphoma opathy-Associated T-Cell Lymphoma: An Algorithmic Approach. Case Rep Oncol 2009; 2: 36-43 73 Bishton MJ, Haynes AP. Combination chemotherapy followed by autologous stem cell transplant for enteropathyassociated T cell lymphoma. Br J Haematol 2007; 136: 111-113 74 Di Raimondo F, Caruso L, Bonanno G, Naso P, Chiarenza A, Fiumara P, Bari A, Palumbo GA, Russo A, Giustolisi R. Is endoscopic ultrasound clinically useful for follow-up of gastric lymphoma? Ann Oncol 2007; 18: 351-356 75 Boot H. Diagnosis and staging in gastrointestinal lymphoma. Best Pract Res Clin Gastroenterol 2010; 24: 3-12 76 Giné E, Montoto S, Bosch F, Arenillas L, Mercadal S, Villamor N, Martínez A, Colomo L, Campo E, Montserrat E, López-Guillermo A. The Follicular Lymphoma International Prognostic Index (FLIPI) and the histological subtype are the most important factors to predict histological transformation in follicular lymphoma. Ann Oncol 2006; 17: 1539-1545 77 Cheson BD, Pfistner B, Juweid ME, Gascoyne RD, Specht L, Horning SJ, Coiffier B, Fisher RI, Hagenbeek A, Zucca E, Rosen ST, Stroobants S, Lister TA, Hoppe RT, Dreyling M, Tobinai K, Vose JM, Connors JM, Federico M, Diehl V. Revised response criteria for malignant lymphoma. J Clin Oncol 2007; 25: 579-586 78 Elstrom RL, Martin P, Leonard JP. New biologic agents and immunologic strategies. Hematol Oncol Clin North Am 2008; 22: 1037-1049, x-xi 79 Paoluzzi L, Kitagawa Y, Kalac M, Zain J, O'Connor OA. New drugs for the treatment of lymphoma. Hematol Oncol Clin North Am 2008; 22: 1007-1035, x 80 Iagaru A, Goris ML, Gambhir SS. Perspectives of molecular imaging and radioimmunotherapy in lymphoma. Radiol Clin North Am 2008; 46: 243-252, viii S- Editor Sun H L- Editor Wang XL E- Editor Lin YP 707 February 14, 2011|Volume 17|Issue 6|
Online Submissions: http://www.wjgnet.com/1007-9327office wjg@wjgnet.com doi:10.3748/wjg.v17.i6.708 ORIGINAL ARTICLE Association of core promoter mutations of hepatitis B virus and viral load is different in HBeAg(+) and HBeAg(-) patients Andi Utama, Marlinang Diarta Siburian, Sigit Purwantomo, Mariana Destila Bayu Intan, Tri Shinta Kurniasih, Rino Alvani Gani, Wenny Astuti Achwan, Arnelis, Syafruddin AR Lelosutan, Benyamin Lukito, Tantoro Harmono, Nasrul Zubir, Julius, Soewignjo Soemohardjo, Laurentius Adrianus Lesmana, Ali Sulaiman, Susan Tai Andi Utama, Marlinang Diarta Siburian, Sigit Purwantomo, Mariana Destila Bayu Intan, Tri Shinta Kurniasih, Susan Tai, Molecular Epidemiology Division, Mochtar Riady Institute for Nanotechnology, Universitas Pelita Harapan, Lippo Karawaci, Tangerang, 15810, Indonesia Rino Alvani Gani, Laurentius Adrianus Lesmana, Ali Sulaiman, Hepatology Division, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia Wenny Astuti Achwan, Soewignjo Soemohardjo, Department of Internal Medicine, Mataram General Hospital, Mataram, 83127, Indonesia Arnelis, Nasrul Zubir, Julius, Gastroentero-Hepatology Division, Department of Internal Medicine, Dr. M. Jamil Hospital, Padang, 25127, Indonesia Syafruddin AR Lelosutan, Gastroentero-Hepatology Division, Department of Internal Medicine, Dr. Gatot Soebroto Hospital, Jakarta, 10410, Indonesia Benyamin Lukito, Department of Internal Medicine, Siloam Hospital Lippo Village, Tangerang, 15810, Indonesia Tantoro Harmono, Department of Internal Medicine, Dr. Moewardi Hospital, Surakarta, 57126, Indonesia Author contributions: Utama A, Siburian MD and Purwantomo S designed and performed the experiments; Intan MDB and Kurniasih TS performed some experiments; Tai S was involved in experiment design and editing the manuscript; Gani RA, Achwan WA, Arnelis, Zubir N, Julius, Soemoharjo S, Lelosutan SAR, Lukito B, Harmono T, Lesmana LA and Sulaiman A coordinated and provided the collection of human materials and were involved in editing the manuscript. Supported by MRIN Funding (Budget No. cc041/2009) Correspondence to: Andi Utama, PhD, Molecular Epidemiology Division, Mochtar Riady Institute for Nanotechnology, Universitas Pelita Harapan, Jalan Boulevard Jend. Sudirman 1688, Lippo Karawaci, Tangerang 15810, Banten, Indonesia. autama@mrinstitute.org Telephone: +62-21-54210123 Fax: +62-21-54210110 Received: September 1, 2010 Revised: November 25, 2010 Accepted: December 2, 2010 Published online: February 14, 2011 WJG|www.wjgnet.com 708 Abstract World J Gastroenterol 2011 February 14; 17(6): 708-716 ISSN 1007-9327 (print) ISSN 2219-2840 (online) © 2011 Baishideng. All rights reserved. AIM: To identify the prevalence of hepatitis B e antigen (HBeAg) and to assess the association of hepatitis B virus (HBV) core promoter mutations and viral load in Indonesian patients. METHODS: Sixty-four patients with chronic hepatitis, 65 with liver cirrhosis and 50 with hepatocellular carcinoma were included in this study. HBeAg and hepatitis B e antibody (HBeAb) tests were performed using enzyme-linked immunosorbent assay and the mutations were analyzed by sequencing. Viral load was measured by real-time polymerase chain reaction. RESULTS: Of 179 patients, 108 (60.3%) were HBeAg(-) and 86 (79.6%) of these HBeAg(-) patients had been seroconverted. The A1896 mutation was not found in HBeAg(+) patients, however, this mutation was detected in 70.7% of HBeAg(-) patients. This mutation was frequently found when HBeAg was not expressed (87.7%), compared to that found in HBeAg seroconverted patients (65.1%). The A1899 mutation was also more prevalent in HBeAg(-) than in HBeAg(+) patients (P = 0.004). The T1762/A1764 mutation was frequently found in both HBeAg(+) and HBeAg(-) patients, however, the prevalence of this mutation did not significantly differ among the two groups (P = 0.054). In HBeAg(+) patients, the T1762/A1764 mutation was correlated with lower HBV DNA (P < 0.001). The A1899 mutation did not correlate with HBV DNA (P = 0.609). In HBeAg(-) patients, the T1762/A1764 mutation alone was not correlated with HBV DNA (P = 0.095), however, the presence of either the T1762/A1764 or A1896 mutations was associated with increased HBV DNA (P < 0.001). CONCLUSION: The percentage of HBeAg(-) patients is high in Indonesia, and most of the HBeAg(-) patients February 14, 2011|Volume 17|Issue 6|
Page 1 and 2: World Journal of Gastroenterology W
Page 3 and 4: Robert JL Fraser, Daw Park Jacob Ge
Page 5 and 6: Italy Donato F Altomare, Bari Piero
Page 7 and 8: Fernando Azpiroz, Barcelona Ramon B
Page 9 and 10: S Contents EDITORIAL REVIEW ORIGINA
Page 11 and 12: Contents ACKNOWLEDGMENTS APPENDIX A
Page 13 and 14: Jahn KA et al . Colon cancer and li
Page 23 and 24: Săftoiu A. Imaging techniques in E
Page 29 and 30: Ghimire P et al . Primary GI lympho
Page 31 and 32: Ghimire P et al . Primary GI lympho
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Page 42 and 43: Table 2 Comparison of hepatitis B e
Page 45 and 46: Utama A et al . HBV core promoter m
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Page 49 and 50: Motoki T et al . Glutamine depletio
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Page 53 and 54: A Motoki T et al . Glutamine deplet
Page 55 and 56: A Counts B % of sub-G0 cell populat
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Page 61 and 62: Abundance/× 10 6 Abundance/× 10 6
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Page 67: Fu JF et al . NAFLD and metabolic s
Page 70 and 71: developing hypertension (OR: 2.18,
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Page 74 and 75: Online Submissions: http://www.wjgn
Page 77 and 78: Roberts SE et al . Perinatal factor
Page 79 and 80: Roberts SE et al . Perinatal factor
Page 81 and 82: Online Submissions: http://www.wjgn
Page 83 and 84: Oksaharju A et al . Probiotics regu
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Oksaharju A et al . Probiotics regu
Page 91:
Online Submissions: http://www.wjgn
Page 96 and 97:
Factors associated with improved su
Page 101 and 102:
Koehler-Santos P et al . Identifica
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Koehler-Santos P et al . Identifica
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Goenka MK et al . Capsule endoscopy
Page 113 and 114:
Tatsuki M et al . Hypermagnesemia a
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Chang CC et al . Parity and gastric
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Chang CC et al . Parity and gastric
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Zhang XQ et al . EEA model of guine
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Table 3 Measurement of common bile
Page 125 and 126:
Zhang XQ et al . EEA model of guine
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Zhao R et al . Gene expression anal
Page 133 and 134:
Zhao R et al . Gene expression anal
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Qiu HB et al . HBV infection and li
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Qiu HB et al . HBV infection and li
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Shen H et al . K-ras and BRAF mutat
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