and HBeAg(-) patients - World Journal of Gastroenterology

Goenka MK et al . Capsule endoscopy in gastrointestinal bleeding
Research frontiers
Previous studies have shown that capsule endoscopy detection rates for the
source of bleeding varies from 38% to 93%, being in the higher range for those
with overt OGIB. Results in most studies are further influenced by subjective
interpretation of “positive findings”. The authors classified our patients depending
on time since last episode of bleed and looked at diagnostic yield in the
different groups with the aim to identify a time-frame to guide clinical decisionmaking
on when to do a capsule endoscopy in this cohort of patients.
Innovations and breakthroughs
Diagnostic yield is significantly affected by the timing of CE and studies done
within 48 h of an episode of overt bleed have the greatest potential for detecting
a definite lesion. The diagnostic yield of CE was not significantly different when
comparing patients with overt OGIB prior to 48 h of CE and those with occult
OGIB. This highlights the importance of obtaining a CE early in the diagnosis of
OGIB.
Applications
This article suggests a potential benefit of doing a capsule endoscopy within
48 h of an episode of bleed in patients with OGIB in terms of increasing chances
of detecting a bleeding source. However, further studies are needed to determine
if early detection of lesion translates into better patient outcome.
Peer review
The paper provides well-collected information about early detection of small
intestinal lesions by CE in obscure GI bleed. Research should be aimed at finding
if early detection results in improved patient outcome.
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S- Editor Sun H L- Editor Kerr C E- Editor Ma WH
778 February 14, 2011|Volume 17|Issue 6|