The North Dakota Nurse - July 2022
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<strong>July</strong>, August, September <strong>2022</strong> <strong>The</strong> <strong>North</strong> <strong>Dakota</strong> <strong>Nurse</strong> Page 15<br />
Ozone Compared to 02<br />
Appraised By:<br />
Amanda Hanson, RN, Mayville State University<br />
RN-to-BSN Student; Ashley Locken, RN, Mayville<br />
State University RN-to-BSN Student; Brandon<br />
Ferguson, RN, Mayville State University RN-to-<br />
BSN Student.<br />
Clinical Question:<br />
In patients hospitalized for COVID-19, how<br />
does integrating ozone treatment compared to<br />
O2 alone affect prognosis?<br />
Articles:<br />
Hernández, A., Viñals, M., Pablos, A., Vilás, F.,<br />
Papadakos, P. J., Wijeysundera, D. N., Bergese,<br />
S. D., & Vives, M. (2020, December 5). Ozone<br />
therapy for patients with COVID-19 pneumonia:<br />
Preliminary report of a prospective case-control<br />
study. International immunopharmacology.<br />
Retrieved April 12, <strong>2022</strong>, from https://www.ncbi.<br />
nlm.nih.gov/pmc/articles/PMC7833586/<br />
Hernández, Viñals, M., Isidoro, T., & Vilás, F. (2020).<br />
Potential Role of Oxygen-Ozone <strong>The</strong>rapy<br />
in Treatment of COVID-19 Pneumonia. <strong>The</strong><br />
American Journal of Case Reports, 21, e925849–<br />
e925849–6. https://doi.org/10.12659/AJCR.925849<br />
Orscelik, A., Karaaslan, B., Agiragac, B., Solmaz,<br />
I., & Parpucu, M. (2020). Could the minor<br />
autohemotherapy be a complementary therapy<br />
for healthcare professionals to prevent COVID-19<br />
infection? Annals of Medical Research,<br />
28(10), 1863–1869. https://doi.org/10.5455/<br />
annalsmedres.2020.11.1133<br />
Synthesis of Evidence:<br />
Ozone therapy is considered a nonpharmacologic<br />
method which can be used<br />
as a complementary therapy when paired<br />
with pharmacologic interventions in the<br />
treatment of COVID-19. <strong>The</strong> treatment method<br />
depends on the severity of the infection and<br />
what stage of the infection the patient is<br />
currently experiencing. Ozone therapy is used<br />
in conjunction with standard treatment for<br />
COVID-19 to improve patient outcomes and<br />
provide for a better prognosis than using O2<br />
therapy alone. “Ozone therapy acts as an<br />
auto-vaccine which can induce the oxidation<br />
of the viral components” and is administered<br />
as a minor hemotherapy (Orscelik, et al, 2020,<br />
g 1863). <strong>The</strong> treatment method depends on<br />
the severity of the infection and what stage<br />
of the infection the patient is currently in. It<br />
also depends on if the patient is receiving<br />
pharmacological treatment for the infection.<br />
<strong>The</strong> research for this study was a random<br />
sample study that was obtained from a group<br />
of people that had tested positive for COVID-19<br />
and were symptomatic. <strong>The</strong> research that<br />
was conduced was used to determine the<br />
benefits of the use of ozone therapy for patients<br />
that tested positive for COVID-19 and were<br />
experiencing symptoms.<br />
A randomized controlled group that<br />
consists of three covid positive individuals<br />
that acquired covid induced pneumonia,<br />
gave informed consent to receive ozone<br />
oxygenated treatment. <strong>The</strong>se three individuals<br />
that presented with respiratory distress was<br />
a 49-year-old male, 61-year-old male, and<br />
64-year-old female. Each patient received four<br />
to six sessions of the ozone autohemotherapy.<br />
<strong>The</strong> outcomes were that each patient was<br />
able to discharge from the hospital on day two<br />
through four after ozone treatment. Laboratory<br />
tests and chest x-rays obtained before, during<br />
and after treatment and shown significant<br />
improvements throughout the study. None of<br />
these three patients needed invasive measures<br />
for breathing assistance, oxygenation, or<br />
mechanical ventilation. Each patient had an<br />
overall rapid clinical improvement after ozone<br />
therapy.<br />
Bottom Line:<br />
COVID-19 was a rapid outbreak that spread<br />
from person to person through airborne and<br />
droplets causing a global pandemic in March<br />
of 2020. This pandemic continued on through<br />
early <strong>2022</strong>. Guidelines were put in place that<br />
instructed people to isolate in their homes and<br />
wear masks when they were out in public to<br />
hopefully stop the spread of this new infection.<br />
Treatment options were limited due to the<br />
unknowns of the infection transmission, cause,<br />
and barriers. When the infection first surfaced<br />
in the United States, standard treatment was<br />
supplemental oxygen therapy and occasional<br />
antibiotic treatment. Through research and trial<br />
and error, new standards for infection treatment<br />
have surfaced.<br />
One of the new treatments was ozone<br />
therapy. Ozone treatment is an alternative<br />
medical therapy that introduces ozone to the<br />
body. For the treatment of COVID-19, ozone is<br />
mixed with a patient’s blood and reinjected<br />
into the patient’s body. This process is known<br />
as autohemotherapy. “Ozone therapy can<br />
be giving in multiple treatments; it improves<br />
oxygenation through attaching to the blood<br />
cells and it consider to be ‘10 times more soluble<br />
than oxygen’” (Hernadez et. al. 2020). This<br />
therapy is shown to improve the overall immune<br />
system response.<br />
Studies have shown that ozone therapy<br />
combined with supplemental oxygen have<br />
significantly decreased COVID-19 symptoms<br />
and prevented the need for mechanical<br />
ventilation or intubation. Ozone therapy was<br />
trialed in some areas and was found to be<br />
successful in COVID treatment, however, there<br />
is not enough studied evidence to consider it a<br />
true treatment for COVID-19 symptoms.<br />
Ozone therapy can be used in the<br />
treatment of COVID-19 infection in addition<br />
to traditional treatment of the infection. <strong>The</strong>re<br />
is not enough evidence to determine if using<br />
ozone therapy alone would provide better<br />
outcomes for the patient, so it is determined<br />
that using it in addition to oxygen therapy and<br />
pharmacologic treatment provides better<br />
outcomes for the patient. <strong>The</strong>re is still more<br />
research available, and all studies are shortterm<br />
with moderate-small sample sizes.<br />
Implications for Nursing Practice:<br />
Ozone therapy cannot be said to provide<br />
sufficient protection alone but can be used<br />
with other treatments to provide better results in<br />
protection and therapy for COVID-19 infection.<br />
Using ozone as an adjuvant therapy in the<br />
treatment of COVID-19 associated pneumonia<br />
is shown to be beneficial to the patient.<br />
Determining what patients can receive ozone<br />
therapy and which patients are candidate for<br />
other forms of therapy is imperative to ensure<br />
the patient is getting the highest quality of<br />
care/treatment for the best results. Early results<br />
show that ozone therapy does benefit patients<br />
affected by the COVID-19 virus.<br />
<strong>Nurse</strong>s should continue to educate<br />
themselves on potential treatment options for<br />
patients with COVID-19 infection. Many people<br />
are rather skeptical about the infection and<br />
the presented treatment options. Staying up to<br />
date by reading current studies can go a long<br />
way when talking to people about treatment<br />
options for COVID-19 infection, including Ozone<br />
therapy.