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The North Dakota Nurse - July 2022

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<strong>July</strong>, August, September <strong>2022</strong> <strong>The</strong> <strong>North</strong> <strong>Dakota</strong> <strong>Nurse</strong> Page 15<br />

Ozone Compared to 02<br />

Appraised By:<br />

Amanda Hanson, RN, Mayville State University<br />

RN-to-BSN Student; Ashley Locken, RN, Mayville<br />

State University RN-to-BSN Student; Brandon<br />

Ferguson, RN, Mayville State University RN-to-<br />

BSN Student.<br />

Clinical Question:<br />

In patients hospitalized for COVID-19, how<br />

does integrating ozone treatment compared to<br />

O2 alone affect prognosis?<br />

Articles:<br />

Hernández, A., Viñals, M., Pablos, A., Vilás, F.,<br />

Papadakos, P. J., Wijeysundera, D. N., Bergese,<br />

S. D., & Vives, M. (2020, December 5). Ozone<br />

therapy for patients with COVID-19 pneumonia:<br />

Preliminary report of a prospective case-control<br />

study. International immunopharmacology.<br />

Retrieved April 12, <strong>2022</strong>, from https://www.ncbi.<br />

nlm.nih.gov/pmc/articles/PMC7833586/<br />

Hernández, Viñals, M., Isidoro, T., & Vilás, F. (2020).<br />

Potential Role of Oxygen-Ozone <strong>The</strong>rapy<br />

in Treatment of COVID-19 Pneumonia. <strong>The</strong><br />

American Journal of Case Reports, 21, e925849–<br />

e925849–6. https://doi.org/10.12659/AJCR.925849<br />

Orscelik, A., Karaaslan, B., Agiragac, B., Solmaz,<br />

I., & Parpucu, M. (2020). Could the minor<br />

autohemotherapy be a complementary therapy<br />

for healthcare professionals to prevent COVID-19<br />

infection? Annals of Medical Research,<br />

28(10), 1863–1869. https://doi.org/10.5455/<br />

annalsmedres.2020.11.1133<br />

Synthesis of Evidence:<br />

Ozone therapy is considered a nonpharmacologic<br />

method which can be used<br />

as a complementary therapy when paired<br />

with pharmacologic interventions in the<br />

treatment of COVID-19. <strong>The</strong> treatment method<br />

depends on the severity of the infection and<br />

what stage of the infection the patient is<br />

currently experiencing. Ozone therapy is used<br />

in conjunction with standard treatment for<br />

COVID-19 to improve patient outcomes and<br />

provide for a better prognosis than using O2<br />

therapy alone. “Ozone therapy acts as an<br />

auto-vaccine which can induce the oxidation<br />

of the viral components” and is administered<br />

as a minor hemotherapy (Orscelik, et al, 2020,<br />

g 1863). <strong>The</strong> treatment method depends on<br />

the severity of the infection and what stage<br />

of the infection the patient is currently in. It<br />

also depends on if the patient is receiving<br />

pharmacological treatment for the infection.<br />

<strong>The</strong> research for this study was a random<br />

sample study that was obtained from a group<br />

of people that had tested positive for COVID-19<br />

and were symptomatic. <strong>The</strong> research that<br />

was conduced was used to determine the<br />

benefits of the use of ozone therapy for patients<br />

that tested positive for COVID-19 and were<br />

experiencing symptoms.<br />

A randomized controlled group that<br />

consists of three covid positive individuals<br />

that acquired covid induced pneumonia,<br />

gave informed consent to receive ozone<br />

oxygenated treatment. <strong>The</strong>se three individuals<br />

that presented with respiratory distress was<br />

a 49-year-old male, 61-year-old male, and<br />

64-year-old female. Each patient received four<br />

to six sessions of the ozone autohemotherapy.<br />

<strong>The</strong> outcomes were that each patient was<br />

able to discharge from the hospital on day two<br />

through four after ozone treatment. Laboratory<br />

tests and chest x-rays obtained before, during<br />

and after treatment and shown significant<br />

improvements throughout the study. None of<br />

these three patients needed invasive measures<br />

for breathing assistance, oxygenation, or<br />

mechanical ventilation. Each patient had an<br />

overall rapid clinical improvement after ozone<br />

therapy.<br />

Bottom Line:<br />

COVID-19 was a rapid outbreak that spread<br />

from person to person through airborne and<br />

droplets causing a global pandemic in March<br />

of 2020. This pandemic continued on through<br />

early <strong>2022</strong>. Guidelines were put in place that<br />

instructed people to isolate in their homes and<br />

wear masks when they were out in public to<br />

hopefully stop the spread of this new infection.<br />

Treatment options were limited due to the<br />

unknowns of the infection transmission, cause,<br />

and barriers. When the infection first surfaced<br />

in the United States, standard treatment was<br />

supplemental oxygen therapy and occasional<br />

antibiotic treatment. Through research and trial<br />

and error, new standards for infection treatment<br />

have surfaced.<br />

One of the new treatments was ozone<br />

therapy. Ozone treatment is an alternative<br />

medical therapy that introduces ozone to the<br />

body. For the treatment of COVID-19, ozone is<br />

mixed with a patient’s blood and reinjected<br />

into the patient’s body. This process is known<br />

as autohemotherapy. “Ozone therapy can<br />

be giving in multiple treatments; it improves<br />

oxygenation through attaching to the blood<br />

cells and it consider to be ‘10 times more soluble<br />

than oxygen’” (Hernadez et. al. 2020). This<br />

therapy is shown to improve the overall immune<br />

system response.<br />

Studies have shown that ozone therapy<br />

combined with supplemental oxygen have<br />

significantly decreased COVID-19 symptoms<br />

and prevented the need for mechanical<br />

ventilation or intubation. Ozone therapy was<br />

trialed in some areas and was found to be<br />

successful in COVID treatment, however, there<br />

is not enough studied evidence to consider it a<br />

true treatment for COVID-19 symptoms.<br />

Ozone therapy can be used in the<br />

treatment of COVID-19 infection in addition<br />

to traditional treatment of the infection. <strong>The</strong>re<br />

is not enough evidence to determine if using<br />

ozone therapy alone would provide better<br />

outcomes for the patient, so it is determined<br />

that using it in addition to oxygen therapy and<br />

pharmacologic treatment provides better<br />

outcomes for the patient. <strong>The</strong>re is still more<br />

research available, and all studies are shortterm<br />

with moderate-small sample sizes.<br />

Implications for Nursing Practice:<br />

Ozone therapy cannot be said to provide<br />

sufficient protection alone but can be used<br />

with other treatments to provide better results in<br />

protection and therapy for COVID-19 infection.<br />

Using ozone as an adjuvant therapy in the<br />

treatment of COVID-19 associated pneumonia<br />

is shown to be beneficial to the patient.<br />

Determining what patients can receive ozone<br />

therapy and which patients are candidate for<br />

other forms of therapy is imperative to ensure<br />

the patient is getting the highest quality of<br />

care/treatment for the best results. Early results<br />

show that ozone therapy does benefit patients<br />

affected by the COVID-19 virus.<br />

<strong>Nurse</strong>s should continue to educate<br />

themselves on potential treatment options for<br />

patients with COVID-19 infection. Many people<br />

are rather skeptical about the infection and<br />

the presented treatment options. Staying up to<br />

date by reading current studies can go a long<br />

way when talking to people about treatment<br />

options for COVID-19 infection, including Ozone<br />

therapy.

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