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The North Dakota Nurse - July 2022

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Page 6 <strong>The</strong> <strong>North</strong> <strong>Dakota</strong> <strong>Nurse</strong> <strong>July</strong>, August, September <strong>2022</strong><br />

Telehealth Interventions in the Management of Diabetes<br />

Appraised by:<br />

Amanda Papke SN Alyssa Dailey SN, Tayla Gange SN, Tierrany Trudell<br />

SN, , Wallen Masiasa SN, Jonathan Gallagher SN<br />

Allison Sadowsky MSN RN Assistant Professor of Practice (Faculty)<br />

(NDSU School of Nursing at Sanford Health Bismarck)<br />

Clinical Question:<br />

In diabetic patients, what is the effect of telehealth interventions on<br />

patient health outcomes?<br />

Sources of Evidence:<br />

Anderson, A., O’Connell, S.S., Thomas, C., & Chimmanamada, R. (2021).<br />

Telehealth Interventions to Improve Diabetes Management Among Black<br />

and Hispanic Patients: A Systematic Review and Meta-Analysis. Journal of<br />

Racial and Ethnic Health Disparities (<strong>2022</strong>). https://doi.org/10.1007/s40615-<br />

021-01174-6<br />

Baron, J. S., Hirani, S., & Newman, S. P. (2016). A randomized, controlled<br />

trial of the effects of a mobile telehealth intervention on clinical and<br />

patient-reported outcomes in people with poorly controlled diabetes.<br />

Journal of Telemedicine and Telecare, 23(2), 207–216. https://doi.<br />

org/10.1177/1357633x16631628<br />

Eberle, C., & Stichling, S. (2021). Clinical Improvements by Telemedicine<br />

Interventions Managing Type 1 and Type 2 Diabetes: Systematic Metareview.<br />

Journal of medical Internet research, 23(2), 23244. https://doi.<br />

org/10.2196/23244<br />

Wild, S. H., Hanley, J., Lewis, S. C., McKnight, J. A., McCloughan, L. B., Padfield, P.<br />

L., Parker, R. A., Paterson, M., Pinnock, H., Sheikh, A., & McKinstry, B. (2016).<br />

Correction: Supported telemonitoring and glycemic control in people with<br />

type 2 diabetes: <strong>The</strong> Telescot diabetes pragmatic multicenter randomized<br />

controlled trial. PLOS Medicine, 13(10). https://doi.org/10.1371/journal.<br />

pmed.1002163<br />

Wong, V. W., Wang, A., & Manoharan, M. (2021). Utilization of telehealth for<br />

outpatient diabetes management during COVID-19 pandemic: How did<br />

the patients fare? Internal Medicine Journal, 51(12), 2021–2026. https://doi.<br />

org/10.1111/imj.15441<br />

Zhai, Y. K., Zhu, W. J., Cai, Y. L., Sun, D. X., & Zhao, J. (2014). Clinical- and costeffectiveness<br />

of telemedicine in type 2 diabetes mellitus: a systematic<br />

review and meta-analysis. Medicine, 93(28), e312. https://doi.org/10.1097/<br />

MD.0000000000000312<br />

Synthesis of Evidence:<br />

Six articles were reviewed as evidence in this report. <strong>The</strong> articles<br />

included three systematic reviews, a quasi-experimental, and two<br />

single randomized controlled trials. In patients with chronic conditions,<br />

there are various barriers that inhibit management of their disease.<br />

Determining these barriers and researching alternative interventions is<br />

necessary in improving clinical and patient-reported outcomes.<br />

Baron and Newman (2016) conducted a randomized controlled trial<br />

to examine the effects of mobile telehealth on a range of clinical and<br />

patient reported outcomes. <strong>The</strong> study included 81 participants who<br />

were patients diagnosed with type 1 or type 2 diabetes. <strong>The</strong> participants<br />

exchanged medical information daily, including blood glucose and<br />

blood pressure, with the telehealth nurse using a mobile device that<br />

transmitted the data to a web server where it was accessed and<br />

reviewed by the telehealth nurse. Feedback was provided to the patient<br />

based on the transmitted data. Variables such as hemoglobin A1c,<br />

blood pressure, daily insulin doses, and patient-reported outcomes were<br />

studied. <strong>The</strong> results conclude that participants who received access to<br />

the mobile telehealth intervention reported a significant increase in<br />

quality of life, improvement in hemoglobin A1c and a decrease in both<br />

systolic and diastolic blood pressures. Hemoglobin A1c decreased in the<br />

intervention group from an average of 9.07 at baseline to 8.56 at nine<br />

months. Average hemoglobin A1c increased in the control group from<br />

8.88 at baseline to 8.93 at nine months.<br />

Eberle and Stichling (2021) conducted a systematic meta-review of<br />

31 studies. Including 21 SR & MA, 8 RCT, 1 non-RCT, and one qualitative<br />

study. <strong>The</strong>se studies used the intervention of telehealth in various ways<br />

such as text messaging, telephone calls, video conferences, to email.<br />

Patients with type 1 and type 2 diabetes were studied with these clinical<br />

outcomes in mind: HbA1C, FBG (fasting blood glucose), BP, body weight,<br />

BMI, health-related quality of life (HRQoL), diabetes-related quality of<br />

life (DRQoL), cost effectiveness, and time saving. <strong>The</strong> results concluded<br />

a significant improvement in HbA1C. <strong>The</strong>re were also noted positive<br />

effects on BP, FBG, body weight, BMI, DRQoL, HRQoL, time saving, and<br />

cost effectiveness using an intervention of telemedicine to find these<br />

outcomes.<br />

Wild & Hanley (2016) conducted a randomized, parallel, investigatorblind<br />

controlled trial with centralized randomization of 321 people<br />

diagnosed with type 2 diabetes and glycated hemoglobin (HbA1c)<br />

greater than 58 mmol/mol. Patients self-monitored and transmitted their<br />

blood sugar levels to a secure website twice weekly during the morning<br />

and evening. Individuals in the intervention group had a decrease in<br />

HbA1c and Blood Pressure compared to the control group. <strong>The</strong> results<br />

showed that the monitored group HbA1c decreased by 5.60 mmol/mol /<br />

0.51% lower compared with the control group. <strong>The</strong> systolic BP decreased<br />

by 3.06 mmHg & diastolic BP decreased by 2.17 mmHg in the<br />

interventional group compared to the control group. This study showed<br />

that telemonitoring and supported self-management of blood glucose<br />

can result in clinically meaningful improvements in blood glucose among<br />

people with poorly controlled type 2 diabetes.<br />

Anderson, O’Connell, Thomas, and Chimmanamada (2021)<br />

conducted a systematic review and meta-analysis of randomized<br />

controlled trials including nine studies. <strong>The</strong> review and analysis of the<br />

nine studies were used to evaluate the effectiveness of telehealth<br />

interventions aimed at improving HbA1c values among Black and<br />

Hispanic patients with type 2 diabetes connected to primary care.<br />

Telehealth interventions were health care, health education, and health<br />

information services by remote technologies. <strong>The</strong> clinical effectiveness<br />

was aimed at evaluating the hemoglobin A1c pre- and post-telehealth<br />

intervention. <strong>The</strong> major findings indicated a net change decreased by<br />

-0.47%, this is a significant change in this case. <strong>The</strong>se findings suggest<br />

telehealth interventions can be effective at improving glycemic control<br />

among Black and Hispanic diabetes patients.<br />

Zhai, Zhu, Cai, Sun, & Zhao (2014) conducted a systemic Review and<br />

Meta-analysis of 35 randomized controlled studies tied to patients with<br />

type 2 diabetes who were 18 years or older and receiving insulin or oral<br />

diabetic drugs. <strong>The</strong> sample size ranged from 13-844 individuals from<br />

various health care settings. <strong>The</strong> purpose of the study was to evaluate<br />

the clinical effectiveness and cost effectiveness of telemedicine<br />

approaches on glycemic control in patients with type 2 diabetes mellitus.<br />

After implementing the telehealth interventions which included virtual<br />

visits, telephone calls, and website check ins, A1C improved from 6.4-<br />

11.2 to 6.4-8.7. <strong>The</strong> intervention also revealed institute for clinical and<br />

economic review (ICER) of $491 and $29,869 per capita for each unit<br />

reduction in HbA1c, for the telephone and internet base interventions.<br />

Wong, Wang, and Manoharan (2021) conducted a quasiexperimental,<br />

retrospective review of electronic medical records (EMRs)<br />

of 629 outpatient diabetic patients from two major hospitals in Sydney,<br />

Australia for a five-month period. Years reviewed were 2019 and 2020.<br />

Methods used for telehealth consultations consisted of voice calls,<br />

video calls, and sending blood glucose level results electronically. <strong>The</strong><br />

review found that the attendance rate improved from 85.2% to 88.9%,<br />

HbA1c improved from 8.2 to 7.8. <strong>The</strong>re was no statistical significance in<br />

unplanned admissions from 75 readmissions to 58 admissions after the<br />

telehealth interventions were implemented, albeit it improved. HbA1c<br />

was collected one year prior to 2019, one visit prior to the COVID-19<br />

pandemic, and one visit a year after their pre-virtual management<br />

period.<br />

Conclusion:<br />

All six articles supported the use of mobile telehealth interventions in the<br />

care management of patients with diabetes. Five of the six articles showed<br />

clinically significant changes in the hemoglobin A1c (HbA1c), while one<br />

article showed a marginal change in the HbA1c. Across the studies, the<br />

most commonly used modes of telehealth include video conferencing,<br />

telephone calls, texting, and internet programs. <strong>The</strong> evidence suggests<br />

these interventions lead to effective management of diabetes.<br />

Implications for Nursing Practice:<br />

Diabetes is a chronic condition that can have long-lasting effects<br />

on patients. <strong>The</strong> effects the interventions have on diabetic patients<br />

would be beneficial in effectively improving hemoglobin A1c. Care<br />

surrounding the management of diabetes should aim to implement<br />

mobile telehealth interventions as adjunct means to managing diabetes.<br />

Patients should also be encouraged to follow-up with their diabetes<br />

providers for optimal outcomes.

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