The North Dakota Nurse - July 2022
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Page 6 <strong>The</strong> <strong>North</strong> <strong>Dakota</strong> <strong>Nurse</strong> <strong>July</strong>, August, September <strong>2022</strong><br />
Telehealth Interventions in the Management of Diabetes<br />
Appraised by:<br />
Amanda Papke SN Alyssa Dailey SN, Tayla Gange SN, Tierrany Trudell<br />
SN, , Wallen Masiasa SN, Jonathan Gallagher SN<br />
Allison Sadowsky MSN RN Assistant Professor of Practice (Faculty)<br />
(NDSU School of Nursing at Sanford Health Bismarck)<br />
Clinical Question:<br />
In diabetic patients, what is the effect of telehealth interventions on<br />
patient health outcomes?<br />
Sources of Evidence:<br />
Anderson, A., O’Connell, S.S., Thomas, C., & Chimmanamada, R. (2021).<br />
Telehealth Interventions to Improve Diabetes Management Among Black<br />
and Hispanic Patients: A Systematic Review and Meta-Analysis. Journal of<br />
Racial and Ethnic Health Disparities (<strong>2022</strong>). https://doi.org/10.1007/s40615-<br />
021-01174-6<br />
Baron, J. S., Hirani, S., & Newman, S. P. (2016). A randomized, controlled<br />
trial of the effects of a mobile telehealth intervention on clinical and<br />
patient-reported outcomes in people with poorly controlled diabetes.<br />
Journal of Telemedicine and Telecare, 23(2), 207–216. https://doi.<br />
org/10.1177/1357633x16631628<br />
Eberle, C., & Stichling, S. (2021). Clinical Improvements by Telemedicine<br />
Interventions Managing Type 1 and Type 2 Diabetes: Systematic Metareview.<br />
Journal of medical Internet research, 23(2), 23244. https://doi.<br />
org/10.2196/23244<br />
Wild, S. H., Hanley, J., Lewis, S. C., McKnight, J. A., McCloughan, L. B., Padfield, P.<br />
L., Parker, R. A., Paterson, M., Pinnock, H., Sheikh, A., & McKinstry, B. (2016).<br />
Correction: Supported telemonitoring and glycemic control in people with<br />
type 2 diabetes: <strong>The</strong> Telescot diabetes pragmatic multicenter randomized<br />
controlled trial. PLOS Medicine, 13(10). https://doi.org/10.1371/journal.<br />
pmed.1002163<br />
Wong, V. W., Wang, A., & Manoharan, M. (2021). Utilization of telehealth for<br />
outpatient diabetes management during COVID-19 pandemic: How did<br />
the patients fare? Internal Medicine Journal, 51(12), 2021–2026. https://doi.<br />
org/10.1111/imj.15441<br />
Zhai, Y. K., Zhu, W. J., Cai, Y. L., Sun, D. X., & Zhao, J. (2014). Clinical- and costeffectiveness<br />
of telemedicine in type 2 diabetes mellitus: a systematic<br />
review and meta-analysis. Medicine, 93(28), e312. https://doi.org/10.1097/<br />
MD.0000000000000312<br />
Synthesis of Evidence:<br />
Six articles were reviewed as evidence in this report. <strong>The</strong> articles<br />
included three systematic reviews, a quasi-experimental, and two<br />
single randomized controlled trials. In patients with chronic conditions,<br />
there are various barriers that inhibit management of their disease.<br />
Determining these barriers and researching alternative interventions is<br />
necessary in improving clinical and patient-reported outcomes.<br />
Baron and Newman (2016) conducted a randomized controlled trial<br />
to examine the effects of mobile telehealth on a range of clinical and<br />
patient reported outcomes. <strong>The</strong> study included 81 participants who<br />
were patients diagnosed with type 1 or type 2 diabetes. <strong>The</strong> participants<br />
exchanged medical information daily, including blood glucose and<br />
blood pressure, with the telehealth nurse using a mobile device that<br />
transmitted the data to a web server where it was accessed and<br />
reviewed by the telehealth nurse. Feedback was provided to the patient<br />
based on the transmitted data. Variables such as hemoglobin A1c,<br />
blood pressure, daily insulin doses, and patient-reported outcomes were<br />
studied. <strong>The</strong> results conclude that participants who received access to<br />
the mobile telehealth intervention reported a significant increase in<br />
quality of life, improvement in hemoglobin A1c and a decrease in both<br />
systolic and diastolic blood pressures. Hemoglobin A1c decreased in the<br />
intervention group from an average of 9.07 at baseline to 8.56 at nine<br />
months. Average hemoglobin A1c increased in the control group from<br />
8.88 at baseline to 8.93 at nine months.<br />
Eberle and Stichling (2021) conducted a systematic meta-review of<br />
31 studies. Including 21 SR & MA, 8 RCT, 1 non-RCT, and one qualitative<br />
study. <strong>The</strong>se studies used the intervention of telehealth in various ways<br />
such as text messaging, telephone calls, video conferences, to email.<br />
Patients with type 1 and type 2 diabetes were studied with these clinical<br />
outcomes in mind: HbA1C, FBG (fasting blood glucose), BP, body weight,<br />
BMI, health-related quality of life (HRQoL), diabetes-related quality of<br />
life (DRQoL), cost effectiveness, and time saving. <strong>The</strong> results concluded<br />
a significant improvement in HbA1C. <strong>The</strong>re were also noted positive<br />
effects on BP, FBG, body weight, BMI, DRQoL, HRQoL, time saving, and<br />
cost effectiveness using an intervention of telemedicine to find these<br />
outcomes.<br />
Wild & Hanley (2016) conducted a randomized, parallel, investigatorblind<br />
controlled trial with centralized randomization of 321 people<br />
diagnosed with type 2 diabetes and glycated hemoglobin (HbA1c)<br />
greater than 58 mmol/mol. Patients self-monitored and transmitted their<br />
blood sugar levels to a secure website twice weekly during the morning<br />
and evening. Individuals in the intervention group had a decrease in<br />
HbA1c and Blood Pressure compared to the control group. <strong>The</strong> results<br />
showed that the monitored group HbA1c decreased by 5.60 mmol/mol /<br />
0.51% lower compared with the control group. <strong>The</strong> systolic BP decreased<br />
by 3.06 mmHg & diastolic BP decreased by 2.17 mmHg in the<br />
interventional group compared to the control group. This study showed<br />
that telemonitoring and supported self-management of blood glucose<br />
can result in clinically meaningful improvements in blood glucose among<br />
people with poorly controlled type 2 diabetes.<br />
Anderson, O’Connell, Thomas, and Chimmanamada (2021)<br />
conducted a systematic review and meta-analysis of randomized<br />
controlled trials including nine studies. <strong>The</strong> review and analysis of the<br />
nine studies were used to evaluate the effectiveness of telehealth<br />
interventions aimed at improving HbA1c values among Black and<br />
Hispanic patients with type 2 diabetes connected to primary care.<br />
Telehealth interventions were health care, health education, and health<br />
information services by remote technologies. <strong>The</strong> clinical effectiveness<br />
was aimed at evaluating the hemoglobin A1c pre- and post-telehealth<br />
intervention. <strong>The</strong> major findings indicated a net change decreased by<br />
-0.47%, this is a significant change in this case. <strong>The</strong>se findings suggest<br />
telehealth interventions can be effective at improving glycemic control<br />
among Black and Hispanic diabetes patients.<br />
Zhai, Zhu, Cai, Sun, & Zhao (2014) conducted a systemic Review and<br />
Meta-analysis of 35 randomized controlled studies tied to patients with<br />
type 2 diabetes who were 18 years or older and receiving insulin or oral<br />
diabetic drugs. <strong>The</strong> sample size ranged from 13-844 individuals from<br />
various health care settings. <strong>The</strong> purpose of the study was to evaluate<br />
the clinical effectiveness and cost effectiveness of telemedicine<br />
approaches on glycemic control in patients with type 2 diabetes mellitus.<br />
After implementing the telehealth interventions which included virtual<br />
visits, telephone calls, and website check ins, A1C improved from 6.4-<br />
11.2 to 6.4-8.7. <strong>The</strong> intervention also revealed institute for clinical and<br />
economic review (ICER) of $491 and $29,869 per capita for each unit<br />
reduction in HbA1c, for the telephone and internet base interventions.<br />
Wong, Wang, and Manoharan (2021) conducted a quasiexperimental,<br />
retrospective review of electronic medical records (EMRs)<br />
of 629 outpatient diabetic patients from two major hospitals in Sydney,<br />
Australia for a five-month period. Years reviewed were 2019 and 2020.<br />
Methods used for telehealth consultations consisted of voice calls,<br />
video calls, and sending blood glucose level results electronically. <strong>The</strong><br />
review found that the attendance rate improved from 85.2% to 88.9%,<br />
HbA1c improved from 8.2 to 7.8. <strong>The</strong>re was no statistical significance in<br />
unplanned admissions from 75 readmissions to 58 admissions after the<br />
telehealth interventions were implemented, albeit it improved. HbA1c<br />
was collected one year prior to 2019, one visit prior to the COVID-19<br />
pandemic, and one visit a year after their pre-virtual management<br />
period.<br />
Conclusion:<br />
All six articles supported the use of mobile telehealth interventions in the<br />
care management of patients with diabetes. Five of the six articles showed<br />
clinically significant changes in the hemoglobin A1c (HbA1c), while one<br />
article showed a marginal change in the HbA1c. Across the studies, the<br />
most commonly used modes of telehealth include video conferencing,<br />
telephone calls, texting, and internet programs. <strong>The</strong> evidence suggests<br />
these interventions lead to effective management of diabetes.<br />
Implications for Nursing Practice:<br />
Diabetes is a chronic condition that can have long-lasting effects<br />
on patients. <strong>The</strong> effects the interventions have on diabetic patients<br />
would be beneficial in effectively improving hemoglobin A1c. Care<br />
surrounding the management of diabetes should aim to implement<br />
mobile telehealth interventions as adjunct means to managing diabetes.<br />
Patients should also be encouraged to follow-up with their diabetes<br />
providers for optimal outcomes.