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AuthorYearHellstrom 2005 37 Jadad Q-11Jadad Q-20Jadad Q-31Jadad Q-40Jadad Q-50Melman 2005 38 0 0 0 0 0Valiquette1 0 1 0 12005 39Shabsigh 2005 40 1 0 1 0 0Ardicoglu0 0 0 0 02005 41Melnik 2005 42 1 1 0 0 1Seyam 2005 43 1 0 0 0 1Mirone 2005 44 1 0 0 0 1Nehra 2005 45 1 1 1 0 1Young 2005 46 1 -1 1 0 0McMahon1 1 1 1 12005 47Fowler 2005 48 1 1 1 1 0Haren 2005 49 1 1 1 1 0Carson 2005 50 1 0 1 0 1Mahon 2005 51 1 0 1 1 0Rosano 2005 52 1 0 1 1 1Kirby 2005 53 1 0 1 1 1De Rose 2005 54 1 1 0 0 1Gontero 2005 55 1 1 1 1 1Katz 2005 56 1 1 1 0 1Carson 2004 50 1 -1 1 1 1Fonseca 2004 57 1 0 1 0 0Wheatley 2004 58 1 1 1 1 0Abdel-Naser1 0 0 0 12004 59Parsons 2004 60 1 1 1 0 0Deveci 2004 61 1 0 1 0 0Seftel 2004 62 1 0 0 0 0Eardley 2004 63 1 0 0 0 0Gentile 2004 64 1 -1 1 0 0Staab 2004 65 1 -1 1 1 1Montorsi 2004 66 1 0 1 1 0Skoumal 2004 67 1 1 1 1 1Rosen 2004 68 1 -1 1 0 1Shabsigh 2004 69 1 0 1 1 0Seftel 2004 70 1 1 1 1 1Nagao 2004 71 1 -1 1 1 1TotalScoresAllocationConcealment2 Unclear0 Unclear3 Unclear2 Unclear0 Unclear3 Adequate2 Unclear2 Unclear4 Unclear1 Unclear5 Unclear4 Adequate4 Unclear3 Unclear3 Unclear4 Unclear4 Unclear3 Adequate5 Adequate4 Unclear4 Unclear2 Unclear4 Adequate2 Unclear3 Inadequate2 Unclear1 Inadequate1 Unclear2 Unclear3 Adequate3 Unclear5 Unclear2 Unclear3 Unclear5 Unclear3 AdequatePerimenis 2004 72 1 -1 1 -1 1 1 UnclearTignol 2004 73 1 0 0 0 0 1 UnclearPerimenis 2004 74 1 1 1 1 1 5 UnclearCarson 2004 75 1 1 0 0 1 3 UnclearEardley 2004 76 1 0 1 0 1 3 UnclearStief 2004 77 1 1 0 0 0 2 UnclearHatzichristou 1 0 1 1 1 4 UnclearF-2
AuthorYearJadad Q-1 Jadad Q-2 Jadad Q-3 Jadad Q-4 Jadad Q-5Cavallini 2004 79 1 1 1 1 1Rosen 2004 80 1 1 0 0 0von Keitz 2004 81 1 0 1 1 0Leder 2004 82 1 0 1 1 1Diamond 2004 83 1 1 1 0 0Mancini 2004 84 1 0 1 1 0Perimenis 2004 85 1 0 1 0 1Govier 2003 86 1 -1 0 0 0Fox 2003 87 1 0 0 0 1Brock 2003 88 1 -1 1 0 1Padma-Nathan1 0 1 1 02003 89Hellstrom 2003 90 1 1 1 1 1Montorsi 2003 91 1 0 1 1 1Porst 2003 92 1 -1 0 0 1Boyanov 2003 93 1 0 1 0 0Anderson 2003 94 1 1 1 1 1Steidle 2003 95 1 0 0 0 1Gontero 2003 96 1 1 0 0 1Aversa 2003 97 1 -1 0 0 0Hagemann1 0 0 0 02003 98Montorsi 2003 99 1 0 0 0 0McNicholas1 0 0 0 02003 100Padma-Nathan1 0 1 0 02003 101Harding 2002 102 1 -1 1 0 0Steidle 2002 103 1 0 1 0 0Thadani 2002 104 1 0 1 0 1Saenz, I 2002 105 1 1 1 0 0Hellstrom1 0 1 0 12002 106Seibel 2002 107 1 0 1 0 1Bocchi 2002 108 1 0 1 0 1Ugarte 2002 109 1 1 1 0 1Gomez 2002 110 1 1 1 1 1Becher 2002 111 1 0 1 0 1Glina 2002 112 1 0 0 0 0Schanz 2002 113 1 0 1 1 1Padma-Nathan1 0 1 0 12002 114Lebret 2002 115 1 0 1 1 0Lindsey 2002 116 0 0 0 0 0Lim 2002 117 0 0 0 0 1van der Windt 1 1 1 0 0TotalScoresAllocationConcealment5 Adequate2 Adequate3 Unclear4 Unclear3 Unclear3 Unclear3 Unclear1 Unclear2 Unclear2 Unclear3 Unclear5 Adequate4 Unclear1 Unclear2 Unclear5 Unclear2 Unclear3 Unclear0 Unclear1 Unclear1 Unclear1 Unclear2 Unclear2 Unclear2 Unclear3 Unclear3 Inadequate3 Unclear3 Unclear3 Unclear4 Adequate5 Adequate3 Unclear1 Unclear4 Unclear3 Unclear3 Unclear0 Unclear1 Unclear3 UnclearF-3
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This report is based on research co
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This document is in the public doma
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AcknowledgmentsThe authors would li
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ContentsExecutive Summary..........
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Table 17: Intra-urethral Treatment:
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Figure 63. Absolute Mean Change Fro
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associated with ED treatments. Two
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ED as a main complaint. In only one
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different formulations/modes of app
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Evidence Report
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flaccidity are no less important th
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prostatectomy, antipsychotic agents
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disease). Furthermore, there is ins
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Analytic FrameworkFigure 1. Analyti
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KQ 3. Harms of pharmaceutical treat
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Figure 2. Modified QUOROM Flow Char
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that included intervention characte
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Prevalence of Hypogonadism (Total S
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stimulation and a challenge test wi
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Overview of Trials79-84,86-88,90,91
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131,137,138,142,143,147,151,155,156
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pectoris occurred in a participant
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statistical test results for the ob
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individual Q1-Q15 items, 104,106,15
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Proportion of participants with hea
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erectile maintenance frequency, IIE
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Oral Treatments — Phosphodiestera
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Patients were instructed to take th
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Results obtained from two trials 19
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improved erections was higher in pa
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Clinically homogenous groups of pat
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Oral Treatments — Phosphodiestera
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The approximate proportion of smoke
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value was not reported). Even thoug
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Tadalafil (20 mg) versus tadalafil
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scheduled dosing regimen (90 percen
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Proportion of patients with improve
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Sublingual Treatments - Apomorphine
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been taking over the past two or fo
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apomorphine (5 and 6 mg: 38 and 49
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heterogeneity with respect to popul
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Finally, two studies reported on wh
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the second study, prolonged erectio
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Moxisylate versus placebo. One tria
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Quantitative SynthesisThere was a l
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erection” versus one placebo trea
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methods of allocation concealment.
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Prazosin (IU) versus placebo. One t
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reported adequate allocation concea
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Hormonal Treatments Literature Sear
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Harms. In the first trial, the diff
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sex with partner (scale 1-6, with =
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daily for 4 weeks followed by concu
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(MEDQoL) score (range 0-100) compar
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group (16.7, 12.5, and 8.3 percent,
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Question 3a. What Are the harms of
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Chapter 4. DiscussionThis evidence
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Question 1: What is the Clinical Ut
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Questions 2-3: What are the Benefit
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Harms. There were no obvious differ
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alone. Compared with trimix alone,
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PhentolamineEfficacy. The results i
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Question 2a-b: Do Specific Patient
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Methodological and Logistic Limitat
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Tables and Figures.Summary TablesTa
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123Study details 1 Study Design Set
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125Table 2: Prevalence of Hypogonad
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127Study Details 2 Study Design Set
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129Table 4: Prevalence of Hypogonad
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131Study Details 5 Study Design Set
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Table 7: Prevalence of Hyperprolact
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135StudyEDDetails 8 Study Design Se
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Table 10: Serious Adverse Events in
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Table 11: Efficacy Results of Tadal
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Treatment Control Relative RiskStud
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Treatment Control Relative RiskStud
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Table 14: Intracavernosal Injection
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StudyAdverse EventsTreatmentGroup%
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StudyAdverse EventsTreatment Contro
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Study / Typeof PatientsOutcome Defi
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Study ED Etiology OutcomeWilliams*1
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Physiologic:60.0 (18/30) 90.0 (27/3
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StudyAdverse EventTreatmentGroup% (
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TreatmentStudy ED Etiology Group% (
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StudyAdverse EventCavallini 1991 Pa
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Study/patient CharacteristicsGooma
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Aversa 2003Men witharteriogenicEDYa
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Study/patientCharacteristicsClopper
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Study/patientCharacteristicsOutcome
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Table 26: Testosterone Treatment: P
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McNicholas2002Patients reporting
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175Table 27: Miscellaneous Treatmen
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177Table 28: Nonarteritic Anterior
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Table 29: Penile Fibrosis in Studie
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StudyStudyDesignPatientsage range 4
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Figure 6. Improved erection (GEQ-Q1
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Figure 11. Visual disturbances (all
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Figure 16. Any adverse events (trea
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Figure 23. The mean IIEF-Q4 score:
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Figure 30. Improved erection (GEQ-Q
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Figure 37. Visual disturbances (all
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Figure 43. IIEF-EF ≥ 26 at follow
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Figure 49. Dyspepsia (all cause)Fig
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Figure 55. Serious adverse events (
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Figure 61. Mean per-patient percent
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Figure 67. Any adverse events (all-
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Figure 73. Any adverse events (all-
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in men with erectile dysfunction. J
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parameters in obese men with erecti
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comparative crossover study. Androl
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153. Shabsigh R. Efficacy of silden
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190.191.Stief C, Porst H, Saenz dT,
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treatment of men with erectile dysf
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randomized trial. J Urol 1997 Oct;1
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moderate and severe ED. Int J Impot
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349.350.351.randomized, placebo-con
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395. Moher D, Schulz KF, Altman DG.
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PSVRCTRIRIASBPSCSDSETTGTRTWMDpeak s
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dDegDept.Ff/uFHxhrHxIGMmaxminmoNANI
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30. or/24-2931. (ANIMALS not HUMAN)
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27. limit 26 to yr="1990 - 2008"28.
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5. exp clinical trials/6. random$.m
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20. or/17-1921. 16 and 2022. limit
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A systematic review of harms associ
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B-4Summary Table- Randomized Contro
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The Quality Assessment of Studies o
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AuthorFundingN; study design; eligi
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C-10 AuthorFundingN; study design;
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C-146 C5-Intracavernousal Injection
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C-202 C8-Topical Treatments of ED A
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C-216 C9-Testosterone Treatment of
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men with erectile dysfunction and s
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symptoms associated with benign pro
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(84) Zinner N. Do food and dose tim
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(117) Carrier S, Brock GB, Pommervi
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(150) Hagemann JH, Berding G, Bergh
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(183) Moriel EZ, Rajfer J. Sodium b
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(219) Gomaa A, Shalaby M, Osman M e
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(255)(256)dysfunction. Psychopharma
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Adams Henry E, Motsinger Patrice, M
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Althof S E, Turner L A, Levine S B
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Anonymous. Surgery & watchful waiti
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Baker Christine D. A cognitive-beha
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Bayes M, Rabasseda X, Prous J R. Ga
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Bhatnagar V, Stewart S T, Huynh V e
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Boswell-Smith V, Spina D, Page C P.
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Burke J P, Jacobson D J, McGree M E
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Carson C C. Combination of phosphod
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Chen Y. Acupuncture treatment of fu
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Cooke B M, Breedlove S M, Jordan C
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Daitch J A, Angermeier K W, Lakin M
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Derouet H, Jost W H, Osterhage J et
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Doust J, Miller E, Duchesne G et al
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Elhilali M M. Alfuzosin: An a1-rece
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Ferri C, Giuggioli D, Cazzato M et
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Frucht S J. Parkinson disease: An u
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Ghofrani H A, Pepke-Zaba J, Barbera
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Baldwin D S. Sexual dysfunction ass
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Douglass M A, Lin J C. Update on th
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Hatch J P. Psychophysiological aspe
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Lau D H, Mumtaz F H, Thompson C S e
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Morales A, Heaton J P. Hormonal ere
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Roehrborn C G, McNicholas T. The Ma
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Uckert S, Stief C G, Jonas U. Curre
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Leungwattanakij S, Flynn V, Hellstr
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Musacchio Najah S, Hartrich Molly,
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Akkus E, Kadioglu A, Esen A et al.
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Ashok S, Sigman M. Bioavailable tes
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Briganti A, Salonia A, Gallina A et
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Chinegwundoh F, Anie K A. Treatment
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Dundar S O. Visual loss associated
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Giammusso B, Gattuso U, Vanaclocha
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Hawton Keith, Catalan Jose, Fagg Jo
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Kell P. Cardiovascular safety of si
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Laumann Edward O, West Suzanne, Gla
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Matthew A G, Goldman A, Trachtenber
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Mulhall J P. Deciphering erectile d
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Parsons J K, Marschke P, Maples P e
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Rojewski M T, Korper S, Schrezenmei
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Shabsigh R. Testosterone therapy in
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Tam S W, Worcel M, Wyllie M. Yohimb
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Webb D J, Freestone S, Allen M J et
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Katlowitz N M, Albano G J, Morales
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Sparwasser C, Treiber U, Bahren W e
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van Basten J P, Van Driel M F, Jonk
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Youssef A F, Fort F L, Ronsen B et
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Cooper A J. Evaluation of I-C papav
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Isidori A M, Giannetta E, Gianfrill
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Armstrong D K, Convery A, Dinsmore
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Buvat J, Montorsi F. Safety and tol
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De Rose A F, Giglio M, Traverso P e
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Gana T E, Quizanos L F, Castell R e
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Hatzichristou D G, Apostolidis A, T
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Kim E D, McVary K T. Topical prosta
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Lundberg L, Olsson J-O, Kihl B. Lon
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Moncada I, Jara J, Subira D et al.
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Rajpurkar A, Dhabuwala C B. Compari
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Shabsigh R. Hypogonadism and erecti
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Anonymous. New erectile dysfunction
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Bolona E R, Uraga M V, Haddad R M e
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Chen J, Greenstein A, Kaver I et al
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Hamed S, Mohamed K, El-taher A et a
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Jeong S-J, Park K, Moon J-D et al.
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La Pera G, Franco Giannotti C, Tagg
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Mann R D. Introduction - Tadalafil.
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Montorsi F, Burnett A L. Erectile d
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Ozdel O, Oguzhanoglu A, Oguzhanoglu
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Ramasubbu Rajamannar. Switching to
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Schwartz E J, Wong P, Graydon R J.
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Stolk E A, Busschbach J J, Caffa M
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Vitezic D. A risk-benefit assessmen
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Knispel H H, Huland H. Influence of
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Padma-Nathan H, Eardley I, Kloner R
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Page 1016 and 1017: The UO-EPC gratefully acknowledges
Page 1020 and 1021: AuthorYearJadad Q-1 Jadad Q-2 Jadad
Page 1022 and 1023: AuthorTotal AllocationJadad Q-1 Jad
Page 1024 and 1025: AuthorYearSaylan 2006 265 Jadad Q-1
Page 1027: F-10STUDY IDQ1:SpectrumQ2.Selection
Page 1030 and 1031: Figure G-2. Sildenafil (any dose) v
Page 1036 and 1037: Figure G-8. Sildenafil (25 mg) vs.
Page 1038 and 1039: Figure G-10. Vardenafil (any dose)
Page 1040 and 1041: Tadalfil20 mg vs. PlaceboFigure G-1
Page 1042 and 1043: Figure G-14. Tadalafil (20 mg) vs.
Page 1044 and 1045: Figure G-16. Tadalafil (20mg) vs. T
Page 1046 and 1047: 5 = Eleven+ attempts Q7: When you a
Page 1048 and 1049: The IIEF-5 score is the sum of ques
Page 1050: El Malik EMA. Erectile dysfunction:
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