Beste apotheek van Nederland

Recommendations

Info

No information found
C-159 AuthorFundingN; study design;eligibilityParticipantscharacteristicsDiagnosis details Intervention OutcomesFu (2004) 168Funding source:NRN screened = NRN randomized = 42 crossoverIG1/IG2, n=42CG, n= NAITT analysis used forprimary outcome: NoInclusion: normal rangeof serum testosterone,PRL, estradiol, FSH, LHand glucoseExclusion: neurogenic orendocrinopathic EDAge, mean(range): 43.5 (2765) yrRace: 100%ChineseCo-morbidities:NRPrevious EDtreatment: NRSmoking status:NRBody weight: NRConcomitantmedications: NRDuration of ED: NRUnderlyingdisease: NRPsychogenic ED:NRPhysiologic ED:NRMixed ED: NRIG1: sodiumnitroprusside ICIG2: papaverine +phentolamine by ICIG1:Dose: sodiumnitroprusside 300microgramsDuration: NAFrequency: onceCompliance: NRIG1:Dose: papaverine 30mg + phentolamine1mgDuration: NAFrequency: onceCompliance: NRPrimary outcome results:Erectioncharacteristics: in IG1: Length: ▲ 4.75(1.45) cmCircumference ▲ 2.59 (1.65) cmRigidity: all patients scored >10, with 25>100Duration of erection (scores >100):24.23(7.96), range 15-45 minIG2:Length ▲ 4.00 (1.80) cmCircumference ▲ 2.71 (2.05) cmRigidity: all patients scored >10, with 28>100Duration of erection (scores >100):37.68 (15.36), range 20-55 minOther outcomes assessed: NAWithdrawals/drop-outs/loss tofollow: NRRun In period: NRWash out period: 1 wkF/u duration: NRWDAE: 0TAE: IG1: 0; IG2: 3 had priapism, 15had local painSAE: 0Other: N of pts reportedslightly different in thereportAscertainment of outcomesassessed: physician assessment ofoutcomes
Page 1 and 2:
This report is based on research co
Page 3 and 4:
This document is in the public doma
Page 5 and 6:
AcknowledgmentsThe authors would li
Page 7 and 8:
ContentsExecutive Summary..........
Page 9 and 10:
Table 17: Intra-urethral Treatment:
Page 11 and 12:
Figure 63. Absolute Mean Change Fro
Page 13 and 14:
associated with ED treatments. Two
Page 15 and 16:
ED as a main complaint. In only one
Page 17 and 18:
different formulations/modes of app
Page 19 and 20:
Evidence Report
Page 21 and 22:
flaccidity are no less important th
Page 23 and 24:
prostatectomy, antipsychotic agents
Page 25 and 26:
disease). Furthermore, there is ins
Page 27:
Analytic FrameworkFigure 1. Analyti
Page 30 and 31:
KQ 3. Harms of pharmaceutical treat
Page 32 and 33:
Figure 2. Modified QUOROM Flow Char
Page 34 and 35:
that included intervention characte
Page 36 and 37:
Prevalence of Hypogonadism (Total S
Page 38 and 39:
stimulation and a challenge test wi
Page 40 and 41:
Overview of Trials79-84,86-88,90,91
Page 42 and 43:
131,137,138,142,143,147,151,155,156
Page 44 and 45:
pectoris occurred in a participant
Page 46 and 47:
statistical test results for the ob
Page 48 and 49:
individual Q1-Q15 items, 104,106,15
Page 50 and 51:
Proportion of participants with hea
Page 52 and 53:
erectile maintenance frequency, IIE
Page 54 and 55:
Oral Treatments — Phosphodiestera
Page 56 and 57:
Patients were instructed to take th
Page 58 and 59:
Results obtained from two trials 19
Page 60 and 61:
improved erections was higher in pa
Page 62 and 63:
Clinically homogenous groups of pat
Page 64 and 65:
Oral Treatments — Phosphodiestera
Page 66 and 67:
The approximate proportion of smoke
Page 68 and 69:
value was not reported). Even thoug
Page 70 and 71:
Tadalafil (20 mg) versus tadalafil
Page 72 and 73:
scheduled dosing regimen (90 percen
Page 74 and 75:
Proportion of patients with improve
Page 76 and 77:
Sublingual Treatments - Apomorphine
Page 78 and 79:
been taking over the past two or fo
Page 80 and 81:
apomorphine (5 and 6 mg: 38 and 49
Page 82 and 83:
heterogeneity with respect to popul
Page 84 and 85:
Finally, two studies reported on wh
Page 86 and 87:
the second study, prolonged erectio
Page 88 and 89:
Moxisylate versus placebo. One tria
Page 90 and 91:
Quantitative SynthesisThere was a l
Page 92 and 93:
erection” versus one placebo trea
Page 94 and 95:
methods of allocation concealment.
Page 96 and 97:
Prazosin (IU) versus placebo. One t
Page 98 and 99:
reported adequate allocation concea
Page 101 and 102:
Hormonal Treatments Literature Sear
Page 103 and 104:
Harms. In the first trial, the diff
Page 105 and 106:
sex with partner (scale 1-6, with =
Page 107 and 108:
daily for 4 weeks followed by concu
Page 109 and 110:
(MEDQoL) score (range 0-100) compar
Page 111 and 112:
group (16.7, 12.5, and 8.3 percent,
Page 113 and 114:
Question 3a. What Are the harms of
Page 115 and 116:
Chapter 4. DiscussionThis evidence
Page 117 and 118:
Question 1: What is the Clinical Ut
Page 119 and 120:
Questions 2-3: What are the Benefit
Page 121 and 122:
Harms. There were no obvious differ
Page 123 and 124:
alone. Compared with trimix alone,
Page 125 and 126:
PhentolamineEfficacy. The results i
Page 127 and 128:
Question 2a-b: Do Specific Patient
Page 129 and 130:
Methodological and Logistic Limitat
Page 131:
Tables and Figures.Summary TablesTa
Page 135:
123Study details 1 Study Design Set
Page 139:
125Table 2: Prevalence of Hypogonad
Page 143:
127Study Details 2 Study Design Set
Page 147:
129Table 4: Prevalence of Hypogonad
Page 151:
131Study Details 5 Study Design Set
Page 155:
Table 7: Prevalence of Hyperprolact
Page 159:
135StudyEDDetails 8 Study Design Se
Page 163 and 164:
Table 10: Serious Adverse Events in
Page 165 and 166:
Table 11: Efficacy Results of Tadal
Page 167 and 168:
Treatment Control Relative RiskStud
Page 169 and 170:
Treatment Control Relative RiskStud
Page 171 and 172:
Table 14: Intracavernosal Injection
Page 173 and 174:
StudyAdverse EventsTreatmentGroup%
Page 175 and 176:
StudyAdverse EventsTreatment Contro
Page 177 and 178:
Study / Typeof PatientsOutcome Defi
Page 179 and 180:
Study ED Etiology OutcomeWilliams*1
Page 181 and 182:
Physiologic:60.0 (18/30) 90.0 (27/3
Page 183 and 184:
StudyAdverse EventTreatmentGroup% (
Page 185 and 186:
TreatmentStudy ED Etiology Group% (
Page 187 and 188:
StudyAdverse EventCavallini 1991 Pa
Page 189 and 190:
Study/patient CharacteristicsGooma
Page 191 and 192:
Aversa 2003Men witharteriogenicEDYa
Page 193 and 194:
Study/patientCharacteristicsClopper
Page 195 and 196:
Study/patientCharacteristicsOutcome
Page 197 and 198:
Table 26: Testosterone Treatment: P
Page 199 and 200:
McNicholas2002Patients reporting
Page 201:
175Table 27: Miscellaneous Treatmen
Page 205:
177Table 28: Nonarteritic Anterior
Page 209 and 210:
Table 29: Penile Fibrosis in Studie
Page 211 and 212:
StudyStudyDesignPatientsage range 4
Page 213 and 214:
Figure 6. Improved erection (GEQ-Q1
Page 215 and 216:
Figure 11. Visual disturbances (all
Page 217 and 218:
Figure 16. Any adverse events (trea
Page 219 and 220:
Figure 23. The mean IIEF-Q4 score:
Page 221 and 222:
Figure 30. Improved erection (GEQ-Q
Page 223 and 224:
Figure 37. Visual disturbances (all
Page 225 and 226:
Figure 43. IIEF-EF ≥ 26 at follow
Page 227 and 228:
Figure 49. Dyspepsia (all cause)Fig
Page 229 and 230:
Figure 55. Serious adverse events (
Page 231 and 232:
Figure 61. Mean per-patient percent
Page 233 and 234:
Figure 67. Any adverse events (all-
Page 235 and 236:
Figure 73. Any adverse events (all-
Page 237 and 238:
in men with erectile dysfunction. J
Page 239 and 240:
parameters in obese men with erecti
Page 241 and 242:
comparative crossover study. Androl
Page 243 and 244:
153. Shabsigh R. Efficacy of silden
Page 245 and 246:
190.191.Stief C, Porst H, Saenz dT,
Page 247 and 248:
treatment of men with erectile dysf
Page 249 and 250:
randomized trial. J Urol 1997 Oct;1
Page 251 and 252:
moderate and severe ED. Int J Impot
Page 253 and 254:
349.350.351.randomized, placebo-con
Page 255 and 256:
395. Moher D, Schulz KF, Altman DG.
Page 257 and 258:
PSVRCTRIRIASBPSCSDSETTGTRTWMDpeak s
Page 259 and 260:
dDegDept.Ff/uFHxhrHxIGMmaxminmoNANI
Page 261 and 262:
30. or/24-2931. (ANIMALS not HUMAN)
Page 263 and 264:
27. limit 26 to yr="1990 - 2008"28.
Page 265 and 266:
5. exp clinical trials/6. random$.m
Page 267 and 268:
20. or/17-1921. 16 and 2022. limit
Page 269 and 270:
A systematic review of harms associ
Page 271:
B-4Summary Table- Randomized Contro
Page 274 and 275:
The Quality Assessment of Studies o
Page 277:
AuthorFundingN; study design; eligi
Page 281:
Page 285:
Page 289:
Page 293:
C-10 AuthorFundingN; study design;
Page 297:
Page 301:
Page 305:
Page 309:
Page 313:
Page 317:
Page 321:
Page 325:
Page 329:
Page 333:
Page 337:
Page 341:
Page 345:
Page 349:
Page 353:
Page 357:
Page 361:
Page 365:
Page 369:
Page 373:
Page 377:
Page 381:
Page 385:
Page 389:
Page 393:
Page 397:
Page 401:
Page 405:
Page 409:
Page 413:
Page 417:
Page 421:
Page 425:
Page 429:
Page 433:
Page 437:
Page 441:
Page 445:
Page 449:
Page 453:
Page 457:
Page 461:
Page 465:
Page 469:
Page 473:
Page 477:
Page 481:
Page 485:
Page 489:
Page 493:
Page 497:
Page 501:
Page 505:
Page 509:
Page 513:
Page 517:
Page 521:
Page 525:
Page 529:
Page 533:
Page 537:
Page 541: AuthorFundingN; study design; eligi
Page 545: C-136 AuthorFundingN; study design;
Page 565: C-146 C5-Intracavernousal Injection
Page 643:
Page 647:
Page 651:
Page 655:
C-191 C6-Subcutaneous Treatment Tri
Page 659:
Page 663:
C-195 C7- Intra-urethral Suppositor
Page 667:
Page 671:
Page 675:
Page 679:
Page 683:
Page 687:
Page 691:
Page 695:
Page 699:
Page 703:
Page 707:
Page 711:
Page 715:
Page 719:
Page 723:
Page 727:
Page 731:
Page 735:
Page 739:
Page 743:
Page 747:
C-237 C10-Off Label Treatments Auth
Page 751:
Page 755:
Page 759:
Page 763:
Page 767:
Page 771:
Page 775:
Page 779:
Page 783:
Page 787 and 788:
References(1) Abdel-Naser MB, Imam
Page 789 and 790:
in Colombia, Ecuador, and Venezuela
Page 791 and 792:
(67) Rendell MS, Rajfer J, Wicker P
Page 793 and 794:
(100) Martin-Morales A, Meijide F,
Page 795 and 796:
controlled study. Urology 2006; 68(
Page 797 and 798:
(166) el-Saleh JC, Keogh EJ, Chew K
Page 799 and 800:
(201) Wessells H, Levine N, Hadley
Page 801 and 802:
with hypogonadal symptoms. Arch Gen
Page 803 and 804:
Appendix D. Reference List of Exclu
Page 805 and 806:
Akduman B, Crawford E D. The PCPT:
Page 807 and 808:
Anderson R U, Wise D, Sawyer T et a
Page 809 and 810:
Atala A, Amin M. Current concepts i
Page 811 and 812:
Barbaree H E, Mewhort D J. The effe
Page 813 and 814:
Bereczky Z, Bolus M, Chetty P et al
Page 815 and 816:
Blaya C, Seganfredo A C, Dornelles
Page 817 and 818:
Brioni J D, Moreland R B, Cowart M
Page 819 and 820:
Campbell S F. Science, art and drug
Page 821 and 822:
Champion H C. Erectile dysfunction
Page 823 and 824:
Chung W S, Choi H K. Erotic erectio
Page 825 and 826:
Crasilneck Harold B. Hypnotic techn
Page 827 and 828:
De Leval J, Boca P, Youssef E et al
Page 829 and 830:
Doggrell S A. Combination of finast
Page 831 and 832:
Eardley I. Optimisation of PDE5 Inh
Page 833 and 834:
Evans M F. Critical appraisal: Lose
Page 835 and 836:
Formenti S C, Lieskovsky G, Simonea
Page 837 and 838:
Garcia-Campayo Javier, Sanz-Carrill
Page 839 and 840:
Gleave M, Qian J, Andreou C et al.
Page 841 and 842:
Carson C C. Erectile dysfunction: E
Page 843 and 844:
Glina S. Testosterone and erectile
Page 845 and 846:
Kalsi J S, Bahadur G, Muneer A et a
Page 847 and 848:
McMahon C G. New treatment options
Page 849 and 850:
Padma-Nathan H. Efficacy and tolera
Page 851 and 852:
Shabsigh R, Rajfer J, Aversa A et a
Page 853 and 854:
Wincze John P, Carey Michael P. Sex
Page 855 and 856:
Tan R S. Novel treatment options fo
Page 857 and 858:
Gupta A, Cohen B H, Ruggieri P et a
Page 859 and 860:
Anonymous. Sildenafil appears safe
Page 861 and 862:
Bella A J, Brock G B. Tadalafil: A
Page 863 and 864:
Carson C C, Burnett A L, Levine L A
Page 865 and 866:
Curran M, Keating G. Tadalafil.[err
Page 867 and 868:
Fagan T C, Buttler S, Marbury T et
Page 869 and 870:
Greenstein A, Plymate S R, Katz P G
Page 871 and 872:
Hunter R H, Joy C B, Kennedy E et a
Page 873 and 874:
Kloner R A, Mitchell M, Emmick J T.
Page 875 and 876:
Long R L, Sherman L S, Lombardi T J
Page 877 and 878:
Miller N, Smolkin M E, Bissonette E
Page 879 and 880:
Nurnberg H, George. Erectile Dysfun
Page 881 and 882:
Porst H, Giuliano F, Glina S et al.
Page 883 and 884:
Salonia Andrea, Briganti Alberto, M
Page 885 and 886:
Solursh Lionel P, Solursh Diane S.
Page 887 and 888:
van Basten J P, Van Driel M F, Hoek
Page 889 and 890:
Yasumoto R, Nishisaka N, Sakakura T
Page 891 and 892:
Chen J, Godschalk M F, Katz P G et
Page 893 and 894:
Hellstrom W J. Vardenafil: a new ap
Page 895 and 896:
Webb D J, Muirhead G J, Wulff M et
Page 897 and 898:
Kim J M, Joh Y D, Huh J D et al. Do
Page 899 and 900:
Tariq S H, Haleem U, Omran M L et a
Page 901 and 902:
Aizenberg Dov, Gur Shay, Zemishlany
Page 903 and 904:
Beretta G, Marzotto M, Zanollo A et
Page 905 and 906:
Cheng E. Real-life safety and effic
Page 907 and 908:
English J C, King D H C, Foley J P.
Page 909 and 910:
Goldstein I, Auerbach S, Padma-Nath
Page 911 and 912:
Jackson G. Sildenafil (Viagra): New
Page 913 and 914:
Lane B Z, Ausmundson S J, Butler R
Page 915 and 916:
McMahon C G. An attempt to standard
Page 917 and 918:
Mulhall J P, Land S, Parker M et al
Page 919 and 920:
Pohanka M, Kanovsky P, Bares M et a
Page 921 and 922:
Ruof J, Graf-Morgenstern M, Mnller
Page 923 and 924:
Sparwasser C, Treiber U, Bahren W e
Page 925 and 926:
Wagner G, Montorsi F, Auerbach S et
Page 927 and 928:
Anderson R A, Martin C W, Kung A W
Page 929 and 930:
Baggaley M R, Hirst J F, Watson J P
Page 931 and 932:
Buvat J, Boujadoue G. Testosterone
Page 933 and 934:
Contreras L N, Masini A M, Danna M
Page 935 and 936:
Engelhardt P F, Daha L K, Zils T et
Page 937 and 938:
Glasser S P. Safety of PDE 5 inhibi
Page 939 and 940:
Holtkamp M, Weissinger F, Meierkord
Page 941 and 942:
Kirby R S. Report from London. Pros
Page 943 and 944:
Lexchin J. New drugs with novel the
Page 945 and 946:
Mealy N E. Avanafil. Drugs of the F
Page 947 and 948:
Nakata M, Takashima S, Kaminou T et
Page 949 and 950:
Phillips B G, Kato M, Pesek C A et
Page 951 and 952:
Saad F, Grahl A S, Aversa A et al.
Page 953 and 954:
Sipski M, Alexander C, Guo X et al.
Page 955 and 956:
Traish A M, Goldstein I, Kim N N. T
Page 957 and 958:
Wilt T J, Fink H A. Is antidepressa
Page 959 and 960:
Price D E, Cooksey G, Jehu D et al.
Page 961 and 962:
Bolona E R, Uraga M V, Haddad R M e
Page 963 and 964:
Anonymous. Sublingual apomorphine:
Page 965 and 966:
Bouloux P. Testim 1% testosterone g
Page 967 and 968:
Christ B, Brockmeier D, Hauck E W e
Page 969 and 970:
Fein R L. Classification of sexual
Page 971 and 972:
Green B G, Martin S. Clinical asses
Page 973 and 974:
John H, Lehmann K, Hauri D. Intraur
Page 975 and 976:
Lee W R. The role of androgen depri
Page 977 and 978:
Mealy N E. Alprostadil cream. Drugs
Page 979 and 980:
Murphy J C, Srinivas S, Terris M K.
Page 981 and 982:
Pommerville P. Drug treatments for
Page 983 and 984:
Saie D J, Sills E S. Hyperprolactin
Page 985 and 986:
Steidle C P, McCullough A R, Kamine
Page 987 and 988:
Weiss J N, Badlani G H, Ravalli R e
Page 989 and 990:
Anonymous. Study shows patients tak
Page 991 and 992:
Bartlik Barbara D, Kaplan Peter, Ka
Page 993 and 994:
Cawello W, Schweer H, Dietrich B et
Page 995 and 996:
Del Popolo G, Li Marzi V, Mondaini
Page 997 and 998:
Gallo L, Perdona S, Autorino R et a
Page 999 and 1000:
Hofner K, Claes H, De Reijke T M et
Page 1001 and 1002:
Kloner R A, Hutter A M, Emmick J T
Page 1003 and 1004:
Maan Z, Arya M, Shergill I et al. P
Page 1005 and 1006:
Montorsi F, Strambi L F, Guazzoni G
Page 1007 and 1008:
Phelps J S, Jain A, Monga M. The Ps
Page 1009 and 1010:
Sato Y, Suzuki N, Adachi H et al. E
Page 1011 and 1012:
Strachan M W, Teoh W L, Don-Wauchop
Page 1013 and 1014:
Weinhardt L S, Carey M P. Prevalenc
Page 1015 and 1016:
Appendix E. Additional Acknowledgme
Page 1017 and 1018:
Appendix F. Quality AssessmentRando
Page 1019 and 1020:
AuthorYearJadad Q-1 Jadad Q-2 Jadad
Page 1021 and 1022:
AuthorYearJadad Q-1 Jadad Q-2 Jadad
Page 1023 and 1024:
Jadad Q-1AuthorYearJadad Q-2 Jadad
Page 1025:
Quality Assessment of Observational
Page 1029 and 1030:
Appendix G. Funnel PlotsSildenafilF
Page 1031 and 1032:
Figure G-3. Sildenafil (any dose) v
Page 1033 and 1034:
Page 1035 and 1036:
Page 1037 and 1038:
VardenafilAny dose vs. PlaceboFigur
Page 1039 and 1040:
Figure G-11. Vardenafil (any dose)
Page 1041 and 1042:
Figure G-13. Tadalafil (20 mg) vs.
Page 1043 and 1044:
20 mg vs. 10 mgFigure G-15. Tadalaf
Page 1045 and 1046:
Appendix H. Instruments Used in the
Page 1047 and 1048:
1 = Very dissatisfied2 = Moderately
Page 1049 and 1050:
Appendix I. List of Unobtained Arti
show all

Beste apotheek van Nederland

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?