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C-192 AuthorFundingN; study design; eligibilityParticipantscharacteristicsDiagnosis details Intervention OutcomesSegraves (1991)200Fundingsource: NRN screened = NRN randomized = 12IG/ CG, n = 12ITT analysis used forprimary outcome: NRAge: NRCo-morbidities:NRPrevious EDtreatment: NRConcomitantmedications: NRDuration of ED: NRUnderlyingdisease: NRIG: apomorphinehydrochloridesubcutaneously(brachial)CG: placebosubcutaneously(brachial)Primary outcome results:peniletumescence (▲ in circumference): n=11exceeded 1 cm after apomorphineinjectionAverage max erection = 2 cm, range0.3–3.0 cmInclusion: coital erectilefailure for at least 6 mo, andany 1 or more of hx ofadequate erections uponawakening at least 2/wk forpreceding mo, hx ofadequate erections lasting ≥5 min during foreplay and/orhx of adequate EF duringmasturbationExclusion: current use ofhypotensive or psychoactivemedication; prior use ofneuroleptic medications;penile blood pressure index≤ 0.70; serum testosterone≤ 450 ng/mL; serum PRL≥ 30 ng/mL; erectile problemjudged to be related tocurrent marital discord;presence of dx known to befrequently associated withEDSmoking status:NRBody weight: NRPsychogenic ED:12Physiologic ED: 0Mixed ED: 0IG1:Dose: (titrated wkly untilfull rigidity or AE) 0.25,and 0.50 0.75 and 1.0mg n=12 received onlyfirst 2 doses; n=9 first 3doses, and n=5 alldosesDuration: NRFrequency: once/wkCompliance: NRCG:Dose: placeboDuration: NRFrequency: once /wkCompliance: NRRun In period: NRWash out period: 50min between injectionsin each session; 1 wkbetween sessionsF/u duration: NROther outcomes assessed: NAWithdrawals/drop-outs/loss to f/u: 0WDAE: 0TAE: NR; AE, n (%): 8 (67); yawning,drowsiness, nausea, and extremeSAE: NRAscertainment of outcomesassessed: Barlow strain gauges; Maxerection, made by visual inspectionwithout palpation, rated independentlyby subject and investigator on scale of0–100%; Max level of SD rated on scaleof 0–100% by subjectOther: 3 pts (25%) did not proceed tothe next dose level due to AE; sign.relationship between nicotine use anabsence of AE (chi-square 6.9, p<0.01)
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This report is based on research co
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This document is in the public doma
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AcknowledgmentsThe authors would li
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ContentsExecutive Summary..........
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Table 17: Intra-urethral Treatment:
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Figure 63. Absolute Mean Change Fro
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associated with ED treatments. Two
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ED as a main complaint. In only one
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different formulations/modes of app
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Evidence Report
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flaccidity are no less important th
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prostatectomy, antipsychotic agents
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disease). Furthermore, there is ins
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Analytic FrameworkFigure 1. Analyti
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KQ 3. Harms of pharmaceutical treat
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Figure 2. Modified QUOROM Flow Char
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that included intervention characte
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Prevalence of Hypogonadism (Total S
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stimulation and a challenge test wi
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Overview of Trials79-84,86-88,90,91
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131,137,138,142,143,147,151,155,156
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pectoris occurred in a participant
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statistical test results for the ob
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individual Q1-Q15 items, 104,106,15
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Proportion of participants with hea
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erectile maintenance frequency, IIE
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Oral Treatments — Phosphodiestera
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Patients were instructed to take th
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Results obtained from two trials 19
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improved erections was higher in pa
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Clinically homogenous groups of pat
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Oral Treatments — Phosphodiestera
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The approximate proportion of smoke
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value was not reported). Even thoug
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Tadalafil (20 mg) versus tadalafil
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scheduled dosing regimen (90 percen
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Proportion of patients with improve
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Sublingual Treatments - Apomorphine
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been taking over the past two or fo
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apomorphine (5 and 6 mg: 38 and 49
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heterogeneity with respect to popul
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Finally, two studies reported on wh
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the second study, prolonged erectio
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Moxisylate versus placebo. One tria
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Quantitative SynthesisThere was a l
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erection” versus one placebo trea
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methods of allocation concealment.
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Prazosin (IU) versus placebo. One t
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reported adequate allocation concea
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Hormonal Treatments Literature Sear
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Harms. In the first trial, the diff
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sex with partner (scale 1-6, with =
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daily for 4 weeks followed by concu
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(MEDQoL) score (range 0-100) compar
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group (16.7, 12.5, and 8.3 percent,
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Question 3a. What Are the harms of
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Chapter 4. DiscussionThis evidence
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Question 1: What is the Clinical Ut
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Questions 2-3: What are the Benefit
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Harms. There were no obvious differ
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alone. Compared with trimix alone,
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PhentolamineEfficacy. The results i
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Question 2a-b: Do Specific Patient
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Methodological and Logistic Limitat
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Tables and Figures.Summary TablesTa
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123Study details 1 Study Design Set
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125Table 2: Prevalence of Hypogonad
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127Study Details 2 Study Design Set
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129Table 4: Prevalence of Hypogonad
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131Study Details 5 Study Design Set
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Table 7: Prevalence of Hyperprolact
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135StudyEDDetails 8 Study Design Se
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Table 10: Serious Adverse Events in
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Table 11: Efficacy Results of Tadal
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Treatment Control Relative RiskStud
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Treatment Control Relative RiskStud
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Table 14: Intracavernosal Injection
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StudyAdverse EventsTreatmentGroup%
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StudyAdverse EventsTreatment Contro
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Study / Typeof PatientsOutcome Defi
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Study ED Etiology OutcomeWilliams*1
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Physiologic:60.0 (18/30) 90.0 (27/3
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StudyAdverse EventTreatmentGroup% (
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TreatmentStudy ED Etiology Group% (
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StudyAdverse EventCavallini 1991 Pa
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Study/patient CharacteristicsGooma
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Aversa 2003Men witharteriogenicEDYa
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Study/patientCharacteristicsClopper
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Study/patientCharacteristicsOutcome
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Table 26: Testosterone Treatment: P
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McNicholas2002Patients reporting
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175Table 27: Miscellaneous Treatmen
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177Table 28: Nonarteritic Anterior
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Table 29: Penile Fibrosis in Studie
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StudyStudyDesignPatientsage range 4
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Figure 6. Improved erection (GEQ-Q1
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Figure 11. Visual disturbances (all
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Figure 16. Any adverse events (trea
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Figure 23. The mean IIEF-Q4 score:
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Figure 30. Improved erection (GEQ-Q
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Figure 37. Visual disturbances (all
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Figure 43. IIEF-EF ≥ 26 at follow
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Figure 49. Dyspepsia (all cause)Fig
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Figure 55. Serious adverse events (
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Figure 61. Mean per-patient percent
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Figure 67. Any adverse events (all-
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Figure 73. Any adverse events (all-
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in men with erectile dysfunction. J
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parameters in obese men with erecti
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comparative crossover study. Androl
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153. Shabsigh R. Efficacy of silden
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190.191.Stief C, Porst H, Saenz dT,
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treatment of men with erectile dysf
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randomized trial. J Urol 1997 Oct;1
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moderate and severe ED. Int J Impot
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349.350.351.randomized, placebo-con
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395. Moher D, Schulz KF, Altman DG.
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PSVRCTRIRIASBPSCSDSETTGTRTWMDpeak s
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dDegDept.Ff/uFHxhrHxIGMmaxminmoNANI
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30. or/24-2931. (ANIMALS not HUMAN)
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27. limit 26 to yr="1990 - 2008"28.
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5. exp clinical trials/6. random$.m
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20. or/17-1921. 16 and 2022. limit
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A systematic review of harms associ
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B-4Summary Table- Randomized Contro
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The Quality Assessment of Studies o
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AuthorFundingN; study design; eligi
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C-10 AuthorFundingN; study design;
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C-146 C5-Intracavernousal Injection
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C-237 C10-Off Label Treatments Auth
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References(1) Abdel-Naser MB, Imam
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in Colombia, Ecuador, and Venezuela
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(67) Rendell MS, Rajfer J, Wicker P
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(100) Martin-Morales A, Meijide F,
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controlled study. Urology 2006; 68(
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(166) el-Saleh JC, Keogh EJ, Chew K
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(201) Wessells H, Levine N, Hadley
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with hypogonadal symptoms. Arch Gen
Page 803 and 804:
Appendix D. Reference List of Exclu
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Akduman B, Crawford E D. The PCPT:
Page 807 and 808:
Anderson R U, Wise D, Sawyer T et a
Page 809 and 810:
Atala A, Amin M. Current concepts i
Page 811 and 812:
Barbaree H E, Mewhort D J. The effe
Page 813 and 814:
Bereczky Z, Bolus M, Chetty P et al
Page 815 and 816:
Blaya C, Seganfredo A C, Dornelles
Page 817 and 818:
Brioni J D, Moreland R B, Cowart M
Page 819 and 820:
Campbell S F. Science, art and drug
Page 821 and 822:
Champion H C. Erectile dysfunction
Page 823 and 824:
Chung W S, Choi H K. Erotic erectio
Page 825 and 826:
Crasilneck Harold B. Hypnotic techn
Page 827 and 828:
De Leval J, Boca P, Youssef E et al
Page 829 and 830:
Doggrell S A. Combination of finast
Page 831 and 832:
Eardley I. Optimisation of PDE5 Inh
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Evans M F. Critical appraisal: Lose
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Formenti S C, Lieskovsky G, Simonea
Page 837 and 838:
Garcia-Campayo Javier, Sanz-Carrill
Page 839 and 840:
Gleave M, Qian J, Andreou C et al.
Page 841 and 842:
Carson C C. Erectile dysfunction: E
Page 843 and 844:
Glina S. Testosterone and erectile
Page 845 and 846:
Kalsi J S, Bahadur G, Muneer A et a
Page 847 and 848:
McMahon C G. New treatment options
Page 849 and 850:
Padma-Nathan H. Efficacy and tolera
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Shabsigh R, Rajfer J, Aversa A et a
Page 853 and 854:
Wincze John P, Carey Michael P. Sex
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Tan R S. Novel treatment options fo
Page 857 and 858:
Gupta A, Cohen B H, Ruggieri P et a
Page 859 and 860:
Anonymous. Sildenafil appears safe
Page 861 and 862:
Bella A J, Brock G B. Tadalafil: A
Page 863 and 864:
Carson C C, Burnett A L, Levine L A
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Curran M, Keating G. Tadalafil.[err
Page 867 and 868:
Fagan T C, Buttler S, Marbury T et
Page 869 and 870:
Greenstein A, Plymate S R, Katz P G
Page 871 and 872:
Hunter R H, Joy C B, Kennedy E et a
Page 873 and 874:
Kloner R A, Mitchell M, Emmick J T.
Page 875 and 876:
Long R L, Sherman L S, Lombardi T J
Page 877 and 878:
Miller N, Smolkin M E, Bissonette E
Page 879 and 880:
Nurnberg H, George. Erectile Dysfun
Page 881 and 882:
Porst H, Giuliano F, Glina S et al.
Page 883 and 884:
Salonia Andrea, Briganti Alberto, M
Page 885 and 886:
Solursh Lionel P, Solursh Diane S.
Page 887 and 888:
van Basten J P, Van Driel M F, Hoek
Page 889 and 890:
Yasumoto R, Nishisaka N, Sakakura T
Page 891 and 892:
Chen J, Godschalk M F, Katz P G et
Page 893 and 894:
Hellstrom W J. Vardenafil: a new ap
Page 895 and 896:
Webb D J, Muirhead G J, Wulff M et
Page 897 and 898:
Kim J M, Joh Y D, Huh J D et al. Do
Page 899 and 900:
Tariq S H, Haleem U, Omran M L et a
Page 901 and 902:
Aizenberg Dov, Gur Shay, Zemishlany
Page 903 and 904:
Beretta G, Marzotto M, Zanollo A et
Page 905 and 906:
Cheng E. Real-life safety and effic
Page 907 and 908:
English J C, King D H C, Foley J P.
Page 909 and 910:
Goldstein I, Auerbach S, Padma-Nath
Page 911 and 912:
Jackson G. Sildenafil (Viagra): New
Page 913 and 914:
Lane B Z, Ausmundson S J, Butler R
Page 915 and 916:
McMahon C G. An attempt to standard
Page 917 and 918:
Mulhall J P, Land S, Parker M et al
Page 919 and 920:
Pohanka M, Kanovsky P, Bares M et a
Page 921 and 922:
Ruof J, Graf-Morgenstern M, Mnller
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Sparwasser C, Treiber U, Bahren W e
Page 925 and 926:
Wagner G, Montorsi F, Auerbach S et
Page 927 and 928:
Anderson R A, Martin C W, Kung A W
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Baggaley M R, Hirst J F, Watson J P
Page 931 and 932:
Buvat J, Boujadoue G. Testosterone
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Contreras L N, Masini A M, Danna M
Page 935 and 936:
Engelhardt P F, Daha L K, Zils T et
Page 937 and 938:
Glasser S P. Safety of PDE 5 inhibi
Page 939 and 940:
Holtkamp M, Weissinger F, Meierkord
Page 941 and 942:
Kirby R S. Report from London. Pros
Page 943 and 944:
Lexchin J. New drugs with novel the
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Mealy N E. Avanafil. Drugs of the F
Page 947 and 948:
Nakata M, Takashima S, Kaminou T et
Page 949 and 950:
Phillips B G, Kato M, Pesek C A et
Page 951 and 952:
Saad F, Grahl A S, Aversa A et al.
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Sipski M, Alexander C, Guo X et al.
Page 955 and 956:
Traish A M, Goldstein I, Kim N N. T
Page 957 and 958:
Wilt T J, Fink H A. Is antidepressa
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Price D E, Cooksey G, Jehu D et al.
Page 961 and 962:
Bolona E R, Uraga M V, Haddad R M e
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Anonymous. Sublingual apomorphine:
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Bouloux P. Testim 1% testosterone g
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Christ B, Brockmeier D, Hauck E W e
Page 969 and 970:
Fein R L. Classification of sexual
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Green B G, Martin S. Clinical asses
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John H, Lehmann K, Hauri D. Intraur
Page 975 and 976:
Lee W R. The role of androgen depri
Page 977 and 978:
Mealy N E. Alprostadil cream. Drugs
Page 979 and 980:
Murphy J C, Srinivas S, Terris M K.
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Pommerville P. Drug treatments for
Page 983 and 984:
Saie D J, Sills E S. Hyperprolactin
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Steidle C P, McCullough A R, Kamine
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Weiss J N, Badlani G H, Ravalli R e
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Anonymous. Study shows patients tak
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Bartlik Barbara D, Kaplan Peter, Ka
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Cawello W, Schweer H, Dietrich B et
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Del Popolo G, Li Marzi V, Mondaini
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Gallo L, Perdona S, Autorino R et a
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Hofner K, Claes H, De Reijke T M et
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Kloner R A, Hutter A M, Emmick J T
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Maan Z, Arya M, Shergill I et al. P
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Montorsi F, Strambi L F, Guazzoni G
Page 1007 and 1008:
Phelps J S, Jain A, Monga M. The Ps
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Sato Y, Suzuki N, Adachi H et al. E
Page 1011 and 1012:
Strachan M W, Teoh W L, Don-Wauchop
Page 1013 and 1014:
Weinhardt L S, Carey M P. Prevalenc
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Appendix E. Additional Acknowledgme
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Appendix F. Quality AssessmentRando
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AuthorYearJadad Q-1 Jadad Q-2 Jadad
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AuthorYearJadad Q-1 Jadad Q-2 Jadad
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Jadad Q-1AuthorYearJadad Q-2 Jadad
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Quality Assessment of Observational
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Appendix G. Funnel PlotsSildenafilF
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Figure G-3. Sildenafil (any dose) v
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VardenafilAny dose vs. PlaceboFigur
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Figure G-11. Vardenafil (any dose)
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Figure G-13. Tadalafil (20 mg) vs.
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20 mg vs. 10 mgFigure G-15. Tadalaf
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Appendix H. Instruments Used in the
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1 = Very dissatisfied2 = Moderately
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Appendix I. List of Unobtained Arti
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