Beste apotheek van Nederland

headaches (RR = 1.02, 95 percent CI: 0.69–1.50) and visual disturbances (RR = 2.87, 95 percent
CI: 0.70–11.80) were not statistically significant (Figures 31 and 33). The latter result may have
been due to the small sample of the meta-analysis (Figure 31). The incidence of all-cause
flushing was significantly greater among participants receiving the higher 50 mg dose of
sildenafil (RR = 1.65, 95 percent CI: 1.13–2.42) (Figure 32).
Sildenafil 50 mg versus sildenafil 100 mg – Efficacy. Proportion of patients with improved
erection.
The difference in the proportion of participants with improved erection (i.e., those who
answered “yes” to GEQ–Q1) between the 50 mg and 100 mg sildenafil treatment groups was not
statistically significant (RR = 1.10, 95 percent CI: 1.00–1.20) (Figure 34).
Sildenafil 50 mg versus sildenafil 100 mg - Harms.
Proportion of patients with all-cause headache, flushing, or visual disturbances. There was no
statistically significant difference between the 100 mg and 50 mg sildenafil treatment groups in
the incidence of all-cause headaches (RR = 1.31, 95 percent CI: 0.93–1.84), flushing (RR = 0.87,
95 percent CI: 0.61–1.23), and visual disturbances (RR = 4.18, 95 percent CI: 0.44– 39.54)
(Figures 35–37).
Assessment of Publication Bias
Funnel plots were generated to assess the extent of asymmetry for each meta-analysis. Visual
inspection of these plots did not reveal any substantial asymmetry. 53 (Figures D-1-8, Appendix
D).
43