Beste apotheek van Nederland

Recommendations

Info

StudyED etiologyTreatmentGroup% (n/N)ControlGroup% (n/N)PgE 1 vs. No Treatment: post–nerve-sparing radical retropubic prostatectomyMontorsi 1997All men had prostatecancer†Relative Risk[95% CI]66.7 (8/12) 20 (3/15) 3.33 [1.12–9.90]PgE 1 + Sexual Counseling vs. PgE 1 : post–nerve-sparing radical retropubic prostatectomy orcystectomyTitta 2006Men had either prostateand/or bladder cancer†Mean IIEF score26.6 (beforesurgery)Mean IIEF score26.1 (beforesurgery)–8.4 (before ICI)23.4(3 months aftersurgery)26.5(18 monthsafter surgery)8.4 (before ICI)21.7(3 months aftersurgery)24.3(18 monthsafter surgery)–p <0.0575.8 (22/29)No ED at end ofstudy50.0 (14/28)No ED at end ofstudy1.52 [0.99–2.32]* Defined as full erection or “positive response,” Grade 4/5 erections, or erections sufficient for intercourse or Rigiscanassessment ≥70% rigidity base or tip lasting ≥10 minutes** Numbers extracted from graph† All men were potent or had normal International Index of Erectile Dysfunction (IIEF) scores at baseline†† Percentage of sexual situations producing an erection144
Table 14: Intracavernosal Injection: Patients with Adverse EventsStudyAdverse EventsTreatmentGroup% (n/N)ControlGroup% (n/N)Absolute RiskDifference[95% CI]Prostaglandins (PgE 1 ) vs. PlaceboBechara 1997 Pain 35.0 (21/60) 0 –Linet 1996Penile painPriapism22.7(54/237)2.5 (6/237)NRNR––Vanderschueren1995Penile pain 11.7(74/630)10.9(23/210)1.0 [-4.0, 6.0]von Heyden1993Penile pain/burningsensation13.3(18/135)NR –Range of reported pain/discomfort (%) 11.7–35.0 0–10.9 NABechara 1997 Prolonged erection 15.0 (9/60) 0 (0/60) –von Heyden1993Hematoma 1.5 (2/135) NR –Colli 1996 Treatment-related 2.2 (3/135) 2.2 (1/45) –von Heyden1993Treatment-related 16.3(22/135)NR –PgE 1 vs. PapaverineEarle 1990 Pain during injection 8.5 (11/129) 4.7 (6/129) 4.0 [-2.0, 10.0]Kattan 1991 Pain during injection 46.0 (23/50) 44.0 (22/50) 2.0 [-17.0, 21.0]Mahmoud 1992 Penile pain 11.5 (6/52) 32.7 (17/52) -21.0 [-37.0,6.0]Range of reported pain/discomfort (%) 8.5–46.0 4.7–44.0 NAEarle 1990 Prolonged erection 0 <1 (1/129) –Kattan 1991 Priapism 0 0 –Kunelius 1998 Prolonged erection 10.0 (3/30) 6.7 (2/30) 3.0 [-11.0, 17.0]Mahmoud 1992 Priapism 0 0 –Range of prolonged erection/priapism (%) 0–10.0 0–6.7 NAKattan 1991 Dizziness/headache 2.0 (1/50) 4.0 (2/50) -2.0 [-9.0, 5.0]PgE 1 vs. Papaverine + PgE 1Floth 1991 Pain 34.2 (13/38) 18.4 (7/38) 16.0 [-4.0, 35.0]145
Page 1 and 2:
This report is based on research co
Page 3 and 4:
This document is in the public doma
Page 5 and 6:
AcknowledgmentsThe authors would li
Page 7 and 8:
ContentsExecutive Summary..........
Page 9 and 10:
Table 17: Intra-urethral Treatment:
Page 11 and 12:
Figure 63. Absolute Mean Change Fro
Page 13 and 14:
associated with ED treatments. Two
Page 15 and 16:
ED as a main complaint. In only one
Page 17 and 18:
different formulations/modes of app
Page 19 and 20:
Evidence Report
Page 21 and 22:
flaccidity are no less important th
Page 23 and 24:
prostatectomy, antipsychotic agents
Page 25 and 26:
disease). Furthermore, there is ins
Page 27:
Analytic FrameworkFigure 1. Analyti
Page 30 and 31:
KQ 3. Harms of pharmaceutical treat
Page 32 and 33:
Figure 2. Modified QUOROM Flow Char
Page 34 and 35:
that included intervention characte
Page 36 and 37:
Prevalence of Hypogonadism (Total S
Page 38 and 39:
stimulation and a challenge test wi
Page 40 and 41:
Overview of Trials79-84,86-88,90,91
Page 42 and 43:
131,137,138,142,143,147,151,155,156
Page 44 and 45:
pectoris occurred in a participant
Page 46 and 47:
statistical test results for the ob
Page 48 and 49:
individual Q1-Q15 items, 104,106,15
Page 50 and 51:
Proportion of participants with hea
Page 52 and 53:
erectile maintenance frequency, IIE
Page 54 and 55:
Oral Treatments — Phosphodiestera
Page 56 and 57:
Patients were instructed to take th
Page 58 and 59:
Results obtained from two trials 19
Page 60 and 61:
improved erections was higher in pa
Page 62 and 63:
Clinically homogenous groups of pat
Page 64 and 65:
Oral Treatments — Phosphodiestera
Page 66 and 67:
The approximate proportion of smoke
Page 68 and 69:
value was not reported). Even thoug
Page 70 and 71:
Tadalafil (20 mg) versus tadalafil
Page 72 and 73:
scheduled dosing regimen (90 percen
Page 74 and 75:
Proportion of patients with improve
Page 76 and 77:
Sublingual Treatments - Apomorphine
Page 78 and 79:
been taking over the past two or fo
Page 80 and 81:
apomorphine (5 and 6 mg: 38 and 49
Page 82 and 83:
heterogeneity with respect to popul
Page 84 and 85:
Finally, two studies reported on wh
Page 86 and 87:
the second study, prolonged erectio
Page 88 and 89:
Moxisylate versus placebo. One tria
Page 90 and 91:
Quantitative SynthesisThere was a l
Page 92 and 93:
erection” versus one placebo trea
Page 94 and 95:
methods of allocation concealment.
Page 96 and 97:
Prazosin (IU) versus placebo. One t
Page 98 and 99:
reported adequate allocation concea
Page 101 and 102:
Hormonal Treatments Literature Sear
Page 103 and 104:
Harms. In the first trial, the diff
Page 105 and 106:
sex with partner (scale 1-6, with =
Page 107 and 108:
daily for 4 weeks followed by concu
Page 109 and 110:
(MEDQoL) score (range 0-100) compar
Page 111 and 112:
group (16.7, 12.5, and 8.3 percent,
Page 113 and 114:
Question 3a. What Are the harms of
Page 115 and 116:
Chapter 4. DiscussionThis evidence
Page 117 and 118:
Question 1: What is the Clinical Ut
Page 119 and 120: Questions 2-3: What are the Benefit
Page 121 and 122: Harms. There were no obvious differ
Page 123 and 124: alone. Compared with trimix alone,
Page 125 and 126: PhentolamineEfficacy. The results i
Page 127 and 128: Question 2a-b: Do Specific Patient
Page 129 and 130: Methodological and Logistic Limitat
Page 131: Tables and Figures.Summary TablesTa
Page 135: 123Study details 1 Study Design Set
Page 139: 125Table 2: Prevalence of Hypogonad
Page 143: 127Study Details 2 Study Design Set
Page 147: 129Table 4: Prevalence of Hypogonad
Page 151: 131Study Details 5 Study Design Set
Page 155: Table 7: Prevalence of Hyperprolact
Page 159: 135StudyEDDetails 8 Study Design Se
Page 163 and 164: Table 10: Serious Adverse Events in
Page 165 and 166: Table 11: Efficacy Results of Tadal
Page 167 and 168: Treatment Control Relative RiskStud
Page 169: Treatment Control Relative RiskStud
Page 173 and 174: StudyAdverse EventsTreatmentGroup%
Page 175 and 176: StudyAdverse EventsTreatment Contro
Page 177 and 178: Study / Typeof PatientsOutcome Defi
Page 179 and 180: Study ED Etiology OutcomeWilliams*1
Page 181 and 182: Physiologic:60.0 (18/30) 90.0 (27/3
Page 183 and 184: StudyAdverse EventTreatmentGroup% (
Page 185 and 186: TreatmentStudy ED Etiology Group% (
Page 187 and 188: StudyAdverse EventCavallini 1991 Pa
Page 189 and 190: Study/patient CharacteristicsGooma
Page 191 and 192: Aversa 2003Men witharteriogenicEDYa
Page 193 and 194: Study/patientCharacteristicsClopper
Page 195 and 196: Study/patientCharacteristicsOutcome
Page 197 and 198: Table 26: Testosterone Treatment: P
Page 199 and 200: McNicholas2002Patients reporting
Page 201: 175Table 27: Miscellaneous Treatmen
Page 205: 177Table 28: Nonarteritic Anterior
Page 209 and 210: Table 29: Penile Fibrosis in Studie
Page 211 and 212: StudyStudyDesignPatientsage range 4
Page 213 and 214: Figure 6. Improved erection (GEQ-Q1
Page 215 and 216: Figure 11. Visual disturbances (all
Page 217 and 218: Figure 16. Any adverse events (trea
Page 219 and 220: Figure 23. The mean IIEF-Q4 score:
Page 221 and 222:
Figure 30. Improved erection (GEQ-Q
Page 223 and 224:
Figure 37. Visual disturbances (all
Page 225 and 226:
Figure 43. IIEF-EF ≥ 26 at follow
Page 227 and 228:
Figure 49. Dyspepsia (all cause)Fig
Page 229 and 230:
Figure 55. Serious adverse events (
Page 231 and 232:
Figure 61. Mean per-patient percent
Page 233 and 234:
Figure 67. Any adverse events (all-
Page 235 and 236:
Figure 73. Any adverse events (all-
Page 237 and 238:
in men with erectile dysfunction. J
Page 239 and 240:
parameters in obese men with erecti
Page 241 and 242:
comparative crossover study. Androl
Page 243 and 244:
153. Shabsigh R. Efficacy of silden
Page 245 and 246:
190.191.Stief C, Porst H, Saenz dT,
Page 247 and 248:
treatment of men with erectile dysf
Page 249 and 250:
randomized trial. J Urol 1997 Oct;1
Page 251 and 252:
moderate and severe ED. Int J Impot
Page 253 and 254:
349.350.351.randomized, placebo-con
Page 255 and 256:
395. Moher D, Schulz KF, Altman DG.
Page 257 and 258:
PSVRCTRIRIASBPSCSDSETTGTRTWMDpeak s
Page 259 and 260:
dDegDept.Ff/uFHxhrHxIGMmaxminmoNANI
Page 261 and 262:
30. or/24-2931. (ANIMALS not HUMAN)
Page 263 and 264:
27. limit 26 to yr="1990 - 2008"28.
Page 265 and 266:
5. exp clinical trials/6. random$.m
Page 267 and 268:
20. or/17-1921. 16 and 2022. limit
Page 269 and 270:
A systematic review of harms associ
Page 271:
B-4Summary Table- Randomized Contro
Page 274 and 275:
The Quality Assessment of Studies o
Page 277:
AuthorFundingN; study design; eligi
Page 281:
Page 285:
Page 289:
Page 293:
C-10 AuthorFundingN; study design;
Page 297:
Page 301:
Page 305:
Page 309:
Page 313:
Page 317:
Page 321:
Page 325:
Page 329:
Page 333:
Page 337:
Page 341:
Page 345:
Page 349:
Page 353:
Page 357:
Page 361:
Page 365:
Page 369:
Page 373:
Page 377:
Page 381:
Page 385:
Page 389:
Page 393:
Page 397:
Page 401:
Page 405:
Page 409:
Page 413:
Page 417:
Page 421:
Page 425:
Page 429:
Page 433:
Page 437:
Page 441:
Page 445:
Page 449:
Page 453:
Page 457:
Page 461:
Page 465:
Page 469:
Page 473:
Page 477:
Page 481:
Page 485:
Page 489:
Page 493:
Page 497:
Page 501:
Page 505:
Page 509:
Page 513:
Page 517:
Page 521:
Page 525:
Page 529:
Page 533:
Page 537:
Page 541:
Page 545:
Page 549:
Page 553:
Page 557:
Page 561:
Page 565:
C-146 C5-Intracavernousal Injection
Page 569:
Page 573:
Page 577:
Page 581:
Page 585:
Page 589:
Page 593:
Page 597:
Page 601:
Page 605:
Page 609:
Page 613:
Page 617:
Page 621:
Page 625:
Page 629:
Page 633:
Page 637:
Page 641:
Page 645:
Page 649:
Page 653:
Page 657:
Page 661:
Page 665:
Page 669:
Page 673:
Page 677:
C-202 C8-Topical Treatments of ED A
Page 681:
Page 685:
Page 689:
Page 693:
Page 697:
Page 701:
Page 705:
C-216 C9-Testosterone Treatment of
Page 709:
Page 713:
Page 717:
Page 721:
Page 725:
Page 729:
Page 733:
Page 737:
Page 741:
Page 745:
Page 749:
Page 753:
Page 757:
Page 761:
Page 765:
Page 769:
Page 773:
Page 777:
Page 781:
Page 785:
Page 788 and 789:
men with erectile dysfunction and s
Page 790 and 791:
symptoms associated with benign pro
Page 792 and 793:
(84) Zinner N. Do food and dose tim
Page 794 and 795:
(117) Carrier S, Brock GB, Pommervi
Page 796 and 797:
(150) Hagemann JH, Berding G, Bergh
Page 798 and 799:
(183) Moriel EZ, Rajfer J. Sodium b
Page 800 and 801:
(219) Gomaa A, Shalaby M, Osman M e
Page 802 and 803:
(255)(256)dysfunction. Psychopharma
Page 804 and 805:
Adams Henry E, Motsinger Patrice, M
Page 806 and 807:
Althof S E, Turner L A, Levine S B
Page 808 and 809:
Anonymous. Surgery & watchful waiti
Page 810 and 811:
Baker Christine D. A cognitive-beha
Page 812 and 813:
Bayes M, Rabasseda X, Prous J R. Ga
Page 814 and 815:
Bhatnagar V, Stewart S T, Huynh V e
Page 816 and 817:
Boswell-Smith V, Spina D, Page C P.
Page 818 and 819:
Burke J P, Jacobson D J, McGree M E
Page 820 and 821:
Carson C C. Combination of phosphod
Page 822 and 823:
Chen Y. Acupuncture treatment of fu
Page 824 and 825:
Cooke B M, Breedlove S M, Jordan C
Page 826 and 827:
Daitch J A, Angermeier K W, Lakin M
Page 828 and 829:
Derouet H, Jost W H, Osterhage J et
Page 830 and 831:
Doust J, Miller E, Duchesne G et al
Page 832 and 833:
Elhilali M M. Alfuzosin: An a1-rece
Page 834 and 835:
Ferri C, Giuggioli D, Cazzato M et
Page 836 and 837:
Frucht S J. Parkinson disease: An u
Page 838 and 839:
Ghofrani H A, Pepke-Zaba J, Barbera
Page 840 and 841:
Baldwin D S. Sexual dysfunction ass
Page 842 and 843:
Douglass M A, Lin J C. Update on th
Page 844 and 845:
Hatch J P. Psychophysiological aspe
Page 846 and 847:
Lau D H, Mumtaz F H, Thompson C S e
Page 848 and 849:
Morales A, Heaton J P. Hormonal ere
Page 850 and 851:
Roehrborn C G, McNicholas T. The Ma
Page 852 and 853:
Uckert S, Stief C G, Jonas U. Curre
Page 854 and 855:
Leungwattanakij S, Flynn V, Hellstr
Page 856 and 857:
Musacchio Najah S, Hartrich Molly,
Page 858 and 859:
Akkus E, Kadioglu A, Esen A et al.
Page 860 and 861:
Ashok S, Sigman M. Bioavailable tes
Page 862 and 863:
Briganti A, Salonia A, Gallina A et
Page 864 and 865:
Chinegwundoh F, Anie K A. Treatment
Page 866 and 867:
Dundar S O. Visual loss associated
Page 868 and 869:
Giammusso B, Gattuso U, Vanaclocha
Page 870 and 871:
Hawton Keith, Catalan Jose, Fagg Jo
Page 872 and 873:
Kell P. Cardiovascular safety of si
Page 874 and 875:
Laumann Edward O, West Suzanne, Gla
Page 876 and 877:
Matthew A G, Goldman A, Trachtenber
Page 878 and 879:
Mulhall J P. Deciphering erectile d
Page 880 and 881:
Parsons J K, Marschke P, Maples P e
Page 882 and 883:
Rojewski M T, Korper S, Schrezenmei
Page 884 and 885:
Shabsigh R. Testosterone therapy in
Page 886 and 887:
Tam S W, Worcel M, Wyllie M. Yohimb
Page 888 and 889:
Webb D J, Freestone S, Allen M J et
Page 890 and 891:
Katlowitz N M, Albano G J, Morales
Page 892 and 893:
Sparwasser C, Treiber U, Bahren W e
Page 894 and 895:
van Basten J P, Van Driel M F, Jonk
Page 896 and 897:
Youssef A F, Fort F L, Ronsen B et
Page 898 and 899:
Cooper A J. Evaluation of I-C papav
Page 900 and 901:
Isidori A M, Giannetta E, Gianfrill
Page 902 and 903:
Armstrong D K, Convery A, Dinsmore
Page 904 and 905:
Buvat J, Montorsi F. Safety and tol
Page 906 and 907:
De Rose A F, Giglio M, Traverso P e
Page 908 and 909:
Gana T E, Quizanos L F, Castell R e
Page 910 and 911:
Hatzichristou D G, Apostolidis A, T
Page 912 and 913:
Kim E D, McVary K T. Topical prosta
Page 914 and 915:
Lundberg L, Olsson J-O, Kihl B. Lon
Page 916 and 917:
Moncada I, Jara J, Subira D et al.
Page 918 and 919:
Ohebshalom M, Parker M, Guhring P e
Page 920 and 921:
Rajpurkar A, Dhabuwala C B. Compari
Page 922 and 923:
Shabsigh R. Hypogonadism and erecti
Page 924 and 925:
Terradas C, Levalle O, Nagelberg A
Page 926 and 927:
Yenicerioglu Y, Kefi A, Aslan G et
Page 928 and 929:
Anonymous. New erectile dysfunction
Page 930 and 931:
Bolona E R, Uraga M V, Haddad R M e
Page 932 and 933:
Chen J, Greenstein A, Kaver I et al
Page 934 and 935:
Derby C A, Barbour M M, Hume A L et
Page 936 and 937:
Foulks C J, Cushner H M. Sexual dys
Page 938 and 939:
Hamed S, Mohamed K, El-taher A et a
Page 940 and 941:
Jeong S-J, Park K, Moon J-D et al.
Page 942 and 943:
La Pera G, Franco Giannotti C, Tagg
Page 944 and 945:
Mann R D. Introduction - Tadalafil.
Page 946 and 947:
Montorsi F, Burnett A L. Erectile d
Page 948 and 949:
Ozdel O, Oguzhanoglu A, Oguzhanoglu
Page 950 and 951:
Ramasubbu Rajamannar. Switching to
Page 952 and 953:
Schwartz E J, Wong P, Graydon R J.
Page 954 and 955:
Stolk E A, Busschbach J J, Caffa M
Page 956 and 957:
Vitezic D. A risk-benefit assessmen
Page 958 and 959:
Bancroft J, Smith G, Munoz M et al.
Page 960 and 961:
Knispel H H, Huland H. Influence of
Page 962 and 963:
Padma-Nathan H, Eardley I, Kloner R
Page 964 and 965:
Bai W J, Zhu J C, Jiang H et al. [A
Page 966 and 967:
Carosa E, Martini P, Brandetti F et
Page 968 and 969:
Doggrell S A. Comparison of clinica
Page 970 and 971:
Gingell C, Buvat J, Jardin A et al.
Page 972 and 973:
Heaton J P, Morales A, Adams M A et
Page 974 and 975:
Kloner R A, Mitchell M, Emmick J T.
Page 976 and 977:
Marks L S, Duda C, Dorey F J et al.
Page 978 and 979:
Montorsi F, Guazzoni G, Bergamaschi
Page 980 and 981:
Padma-Nathan H, Goldstein I, Klimbe
Page 982 and 983:
Reznik I, Zemishlany Z, Kotler M et
Page 984 and 985:
Shamloul Rany, Kamel Ihab, E-Mail A
Page 986 and 987:
Tsujimura A, Yamanaka M, Takahashi
Page 988 and 989:
Zippe C D, Kedia A W, Kedia K et al
Page 990 and 991:
Anonymous. Diagnostic and therapeut
Page 992 and 993:
Briganti A, Chun F K H, Salonia A e
Page 994 and 995:
Clough J. CNS-targeted sexual dysfu
Page 996 and 997:
Emilien G. Alprox-TD NexMed Inc. Cu
Page 998 and 999:
Gryglewska B, Grodzicki T. Betaxolo
Page 1000 and 1001:
Kadioglu A, Erdogru T, Tellaloglu S
Page 1002 and 1003:
Lebret T, Herve J M, Gorny P et al.
Page 1004 and 1005:
Mealy N E. GPI-1485. Drugs of the F
Page 1006 and 1007:
O'Sullivan J D. Apomorphine as an a
Page 1008 and 1009:
Riley Alan. Oral treatments for ere
Page 1010 and 1011:
Silvestri A, Galetta P, Cerquetani
Page 1012 and 1013:
Unnikrishnan A G, Rajaratnam S, Ses
Page 1014 and 1015:
Zhao L. Clinical observation on the
Page 1016 and 1017:
The UO-EPC gratefully acknowledges
Page 1018 and 1019:
AuthorYearHellstrom 2005 37 Jadad Q
Page 1020 and 1021:
AuthorYearJadad Q-1 Jadad Q-2 Jadad
Page 1022 and 1023:
AuthorTotal AllocationJadad Q-1 Jad
Page 1024 and 1025:
AuthorYearSaylan 2006 265 Jadad Q-1
Page 1027:
F-10STUDY IDQ1:SpectrumQ2.Selection
Page 1030 and 1031:
Figure G-2. Sildenafil (any dose) v
Page 1032 and 1033:
Page 1034 and 1035:
Page 1036 and 1037:
Figure G-8. Sildenafil (25 mg) vs.
Page 1038 and 1039:
Figure G-10. Vardenafil (any dose)
Page 1040 and 1041:
Tadalfil20 mg vs. PlaceboFigure G-1
Page 1042 and 1043:
Figure G-14. Tadalafil (20 mg) vs.
Page 1044 and 1045:
Figure G-16. Tadalafil (20mg) vs. T
Page 1046 and 1047:
5 = Eleven+ attempts Q7: When you a
Page 1048 and 1049:
The IIEF-5 score is the sum of ques
Page 1050:
El Malik EMA. Erectile dysfunction:
show all

Beste apotheek van Nederland

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?