Beste apotheek van Nederland

Recommendations

Info

No information found
C-69 AuthorFundingN; study design; eligibilityParticipantscharacteristicsDiagnosis details Intervention OutcomesSafarinejad(2006) 69Fundingsource: notsponsoredN screened = 430 (486entered a preliminary phaseto emphasize the timing andinstruction of sildenafil;responders were excluded)N randomized = 402IG1, n = 205IG2, n = 197ITT analysis used forprimary outcome: yesInclusion: men 18 y or olderwith ED; in a stablerelationship, nonrespondersto sildenafil, andno tx of ED within the last 4wks prior to entering thestudyExclusion: penileanatomical defects, primarydx of another sexualdisorder, use of psychotropicand antidepressantmedications, poorlycontrolled DM, uncontrolledcongestive or ischemic heartdx or renal or liverimpairment, hx of alcohol ordrug abuse, SCI, hx ofprostate cancer,neurological dx causing EDAge, mean(range): 41.5 (2159) yRace: NRCo-morbidities, n(%): DM 44 (12);hypercholesterolemia91 (24.6);hypertension 87(23.5);Ischemic heart dx52 (14)Previous EDtreatment: NRSmoking status:smokers 192 (52)Body weight: NRConcomitantmedications, n (%):Duration of ED,mean (range): 2.8(1.9-7) yUnderlyingdisease, n (%): NSbetween grps:arteriogenic 132(32.8); mixedvasculogenic 105(26); veno-occulsivedysfunction 97 (24);corporeal fibrosis 8(2)Psychogenic ED, n(%): 15 (7.3) vs. 13(6.6)Physiologic ED, n(%): 374 (93)Mixed ED: NRIG1: Sildenafil +CabergolineIG2: Sildenafil +placeboIG1:Dose: sildenafil= 50 ▲rapidly to 100 if notresults were observedwith the attempt;cabergoline= 0.5 mg ▲by 0.25 biwkly up to 1mg/wkDuration: 6 moFrequency: sildenafil:pkg instruciton up to1/d; cabergoline: wklyCompliance: NRIG2:Dose: sildenafil as IG1+placeboDuration: 6 moFrequency: ascabergolineCompliance: NRRun In period: NRWash out period: NRF/u duration: 6 moPrimary outcome results:IIEF, LS mean (SE) scores:Q3: baseline 1.8 (0.2); post tx 3.3 (0.2)vs. 2 (0.2)Q4: baseline 1.7 (0.2); post tx 3.7 (0.2)vs. 2 (0.2)All other IIEF individual questions signimproved with cabergoline, p=0.04IIEF- IcS domain mean score: baseline10 vs. 11; post tx 15 vs. 10Successful intercourse attempts (% withat least one success): 36% vs. 6%Other outcomes assessed: IVELTsign difference between tx grps(p=0.001)Withdrawals/drop-outs/loss to f/u, n(%): 19 (9.3) vs. 13 (6.6)WDAE, n (%): 12 (5.9) vs. 2 (1)TAE, n (%): pts with AE 25 (12.2) vs. 4(2) including nausea, headache,dizziness, somnolenceSAE, n (%): NRAscertainment of outcomesassessed: IIEF, Intra-vaginalejaculatory latency time (IVELT)evaluation, serum T, and PRL levels
Page 1 and 2:
This report is based on research co
Page 3 and 4:
This document is in the public doma
Page 5 and 6:
AcknowledgmentsThe authors would li
Page 7 and 8:
ContentsExecutive Summary..........
Page 9 and 10:
Table 17: Intra-urethral Treatment:
Page 11 and 12:
Figure 63. Absolute Mean Change Fro
Page 13 and 14:
associated with ED treatments. Two
Page 15 and 16:
ED as a main complaint. In only one
Page 17 and 18:
different formulations/modes of app
Page 19 and 20:
Evidence Report
Page 21 and 22:
flaccidity are no less important th
Page 23 and 24:
prostatectomy, antipsychotic agents
Page 25 and 26:
disease). Furthermore, there is ins
Page 27:
Analytic FrameworkFigure 1. Analyti
Page 30 and 31:
KQ 3. Harms of pharmaceutical treat
Page 32 and 33:
Figure 2. Modified QUOROM Flow Char
Page 34 and 35:
that included intervention characte
Page 36 and 37:
Prevalence of Hypogonadism (Total S
Page 38 and 39:
stimulation and a challenge test wi
Page 40 and 41:
Overview of Trials79-84,86-88,90,91
Page 42 and 43:
131,137,138,142,143,147,151,155,156
Page 44 and 45:
pectoris occurred in a participant
Page 46 and 47:
statistical test results for the ob
Page 48 and 49:
individual Q1-Q15 items, 104,106,15
Page 50 and 51:
Proportion of participants with hea
Page 52 and 53:
erectile maintenance frequency, IIE
Page 54 and 55:
Oral Treatments — Phosphodiestera
Page 56 and 57:
Patients were instructed to take th
Page 58 and 59:
Results obtained from two trials 19
Page 60 and 61:
improved erections was higher in pa
Page 62 and 63:
Clinically homogenous groups of pat
Page 64 and 65:
Oral Treatments — Phosphodiestera
Page 66 and 67:
The approximate proportion of smoke
Page 68 and 69:
value was not reported). Even thoug
Page 70 and 71:
Tadalafil (20 mg) versus tadalafil
Page 72 and 73:
scheduled dosing regimen (90 percen
Page 74 and 75:
Proportion of patients with improve
Page 76 and 77:
Sublingual Treatments - Apomorphine
Page 78 and 79:
been taking over the past two or fo
Page 80 and 81:
apomorphine (5 and 6 mg: 38 and 49
Page 82 and 83:
heterogeneity with respect to popul
Page 84 and 85:
Finally, two studies reported on wh
Page 86 and 87:
the second study, prolonged erectio
Page 88 and 89:
Moxisylate versus placebo. One tria
Page 90 and 91:
Quantitative SynthesisThere was a l
Page 92 and 93:
erection” versus one placebo trea
Page 94 and 95:
methods of allocation concealment.
Page 96 and 97:
Prazosin (IU) versus placebo. One t
Page 98 and 99:
reported adequate allocation concea
Page 101 and 102:
Hormonal Treatments Literature Sear
Page 103 and 104:
Harms. In the first trial, the diff
Page 105 and 106:
sex with partner (scale 1-6, with =
Page 107 and 108:
daily for 4 weeks followed by concu
Page 109 and 110:
(MEDQoL) score (range 0-100) compar
Page 111 and 112:
group (16.7, 12.5, and 8.3 percent,
Page 113 and 114:
Question 3a. What Are the harms of
Page 115 and 116:
Chapter 4. DiscussionThis evidence
Page 117 and 118:
Question 1: What is the Clinical Ut
Page 119 and 120:
Questions 2-3: What are the Benefit
Page 121 and 122:
Harms. There were no obvious differ
Page 123 and 124:
alone. Compared with trimix alone,
Page 125 and 126:
PhentolamineEfficacy. The results i
Page 127 and 128:
Question 2a-b: Do Specific Patient
Page 129 and 130:
Methodological and Logistic Limitat
Page 131:
Tables and Figures.Summary TablesTa
Page 135:
123Study details 1 Study Design Set
Page 139:
125Table 2: Prevalence of Hypogonad
Page 143:
127Study Details 2 Study Design Set
Page 147:
129Table 4: Prevalence of Hypogonad
Page 151:
131Study Details 5 Study Design Set
Page 155:
Table 7: Prevalence of Hyperprolact
Page 159:
135StudyEDDetails 8 Study Design Se
Page 163 and 164:
Table 10: Serious Adverse Events in
Page 165 and 166:
Table 11: Efficacy Results of Tadal
Page 167 and 168:
Treatment Control Relative RiskStud
Page 169 and 170:
Treatment Control Relative RiskStud
Page 171 and 172:
Table 14: Intracavernosal Injection
Page 173 and 174:
StudyAdverse EventsTreatmentGroup%
Page 175 and 176:
StudyAdverse EventsTreatment Contro
Page 177 and 178:
Study / Typeof PatientsOutcome Defi
Page 179 and 180:
Study ED Etiology OutcomeWilliams*1
Page 181 and 182:
Physiologic:60.0 (18/30) 90.0 (27/3
Page 183 and 184:
StudyAdverse EventTreatmentGroup% (
Page 185 and 186:
TreatmentStudy ED Etiology Group% (
Page 187 and 188:
StudyAdverse EventCavallini 1991 Pa
Page 189 and 190:
Study/patient CharacteristicsGooma
Page 191 and 192:
Aversa 2003Men witharteriogenicEDYa
Page 193 and 194:
Study/patientCharacteristicsClopper
Page 195 and 196:
Study/patientCharacteristicsOutcome
Page 197 and 198:
Table 26: Testosterone Treatment: P
Page 199 and 200:
McNicholas2002Patients reporting
Page 201:
175Table 27: Miscellaneous Treatmen
Page 205:
177Table 28: Nonarteritic Anterior
Page 209 and 210:
Table 29: Penile Fibrosis in Studie
Page 211 and 212:
StudyStudyDesignPatientsage range 4
Page 213 and 214:
Figure 6. Improved erection (GEQ-Q1
Page 215 and 216:
Figure 11. Visual disturbances (all
Page 217 and 218:
Figure 16. Any adverse events (trea
Page 219 and 220:
Figure 23. The mean IIEF-Q4 score:
Page 221 and 222:
Figure 30. Improved erection (GEQ-Q
Page 223 and 224:
Figure 37. Visual disturbances (all
Page 225 and 226:
Figure 43. IIEF-EF ≥ 26 at follow
Page 227 and 228:
Figure 49. Dyspepsia (all cause)Fig
Page 229 and 230:
Figure 55. Serious adverse events (
Page 231 and 232:
Figure 61. Mean per-patient percent
Page 233 and 234:
Figure 67. Any adverse events (all-
Page 235 and 236:
Figure 73. Any adverse events (all-
Page 237 and 238:
in men with erectile dysfunction. J
Page 239 and 240:
parameters in obese men with erecti
Page 241 and 242:
comparative crossover study. Androl
Page 243 and 244:
153. Shabsigh R. Efficacy of silden
Page 245 and 246:
190.191.Stief C, Porst H, Saenz dT,
Page 247 and 248:
treatment of men with erectile dysf
Page 249 and 250:
randomized trial. J Urol 1997 Oct;1
Page 251 and 252:
moderate and severe ED. Int J Impot
Page 253 and 254:
349.350.351.randomized, placebo-con
Page 255 and 256:
395. Moher D, Schulz KF, Altman DG.
Page 257 and 258:
PSVRCTRIRIASBPSCSDSETTGTRTWMDpeak s
Page 259 and 260:
dDegDept.Ff/uFHxhrHxIGMmaxminmoNANI
Page 261 and 262:
30. or/24-2931. (ANIMALS not HUMAN)
Page 263 and 264:
27. limit 26 to yr="1990 - 2008"28.
Page 265 and 266:
5. exp clinical trials/6. random$.m
Page 267 and 268:
20. or/17-1921. 16 and 2022. limit
Page 269 and 270:
A systematic review of harms associ
Page 271:
B-4Summary Table- Randomized Contro
Page 274 and 275:
The Quality Assessment of Studies o
Page 277:
AuthorFundingN; study design; eligi
Page 281:
Page 285:
Page 289:
Page 293:
C-10 AuthorFundingN; study design;
Page 297:
Page 301:
Page 305:
Page 309:
Page 313:
Page 317:
Page 321:
Page 325:
Page 329:
Page 333:
Page 337:
Page 341:
Page 345:
Page 349:
Page 353:
Page 357:
Page 361: C-44 AuthorFundingN; study design;
Page 439: C-83 C2-Oral Vardenafil AuthorFundi
Page 463:
Page 467:
Page 471:
Page 475:
Page 479:
Page 483:
C-105 C3-Oral Tadalafil AuthorFundi
Page 487:
Page 491:
Page 495:
Page 499:
Page 503:
Page 507:
Page 511:
Page 515:
Page 519:
Page 523:
Page 527:
Page 531:
Page 535:
Page 539:
Page 543:
C-135 F4-Apomorphine (sublingual) A
Page 547:
Page 551:
Page 555:
Page 559:
Page 563:
Page 567:
Page 571:
Page 575:
Page 579:
Page 583:
Page 587:
Page 591:
Page 595:
Page 599:
Page 603:
Page 607:
Page 611:
Page 615:
Page 619:
Page 623:
Page 627:
Page 631:
Page 635:
Page 639:
Page 643:
Page 647:
Page 651:
Page 655:
C-191 C6-Subcutaneous Treatment Tri
Page 659:
Page 663:
C-195 C7- Intra-urethral Suppositor
Page 667:
Page 671:
Page 675:
Page 679:
Page 683:
Page 687:
Page 691:
Page 695:
Page 699:
Page 703:
Page 707:
Page 711:
Page 715:
Page 719:
Page 723:
Page 727:
Page 731:
Page 735:
Page 739:
Page 743:
Page 747:
C-237 C10-Off Label Treatments Auth
Page 751:
Page 755:
Page 759:
Page 763:
Page 767:
Page 771:
Page 775:
Page 779:
Page 783:
Page 787 and 788:
References(1) Abdel-Naser MB, Imam
Page 789 and 790:
in Colombia, Ecuador, and Venezuela
Page 791 and 792:
(67) Rendell MS, Rajfer J, Wicker P
Page 793 and 794:
(100) Martin-Morales A, Meijide F,
Page 795 and 796:
controlled study. Urology 2006; 68(
Page 797 and 798:
(166) el-Saleh JC, Keogh EJ, Chew K
Page 799 and 800:
(201) Wessells H, Levine N, Hadley
Page 801 and 802:
with hypogonadal symptoms. Arch Gen
Page 803 and 804:
Appendix D. Reference List of Exclu
Page 805 and 806:
Akduman B, Crawford E D. The PCPT:
Page 807 and 808:
Anderson R U, Wise D, Sawyer T et a
Page 809 and 810:
Atala A, Amin M. Current concepts i
Page 811 and 812:
Barbaree H E, Mewhort D J. The effe
Page 813 and 814:
Bereczky Z, Bolus M, Chetty P et al
Page 815 and 816:
Blaya C, Seganfredo A C, Dornelles
Page 817 and 818:
Brioni J D, Moreland R B, Cowart M
Page 819 and 820:
Campbell S F. Science, art and drug
Page 821 and 822:
Champion H C. Erectile dysfunction
Page 823 and 824:
Chung W S, Choi H K. Erotic erectio
Page 825 and 826:
Crasilneck Harold B. Hypnotic techn
Page 827 and 828:
De Leval J, Boca P, Youssef E et al
Page 829 and 830:
Doggrell S A. Combination of finast
Page 831 and 832:
Eardley I. Optimisation of PDE5 Inh
Page 833 and 834:
Evans M F. Critical appraisal: Lose
Page 835 and 836:
Formenti S C, Lieskovsky G, Simonea
Page 837 and 838:
Garcia-Campayo Javier, Sanz-Carrill
Page 839 and 840:
Gleave M, Qian J, Andreou C et al.
Page 841 and 842:
Carson C C. Erectile dysfunction: E
Page 843 and 844:
Glina S. Testosterone and erectile
Page 845 and 846:
Kalsi J S, Bahadur G, Muneer A et a
Page 847 and 848:
McMahon C G. New treatment options
Page 849 and 850:
Padma-Nathan H. Efficacy and tolera
Page 851 and 852:
Shabsigh R, Rajfer J, Aversa A et a
Page 853 and 854:
Wincze John P, Carey Michael P. Sex
Page 855 and 856:
Tan R S. Novel treatment options fo
Page 857 and 858:
Gupta A, Cohen B H, Ruggieri P et a
Page 859 and 860:
Anonymous. Sildenafil appears safe
Page 861 and 862:
Bella A J, Brock G B. Tadalafil: A
Page 863 and 864:
Carson C C, Burnett A L, Levine L A
Page 865 and 866:
Curran M, Keating G. Tadalafil.[err
Page 867 and 868:
Fagan T C, Buttler S, Marbury T et
Page 869 and 870:
Greenstein A, Plymate S R, Katz P G
Page 871 and 872:
Hunter R H, Joy C B, Kennedy E et a
Page 873 and 874:
Kloner R A, Mitchell M, Emmick J T.
Page 875 and 876:
Long R L, Sherman L S, Lombardi T J
Page 877 and 878:
Miller N, Smolkin M E, Bissonette E
Page 879 and 880:
Nurnberg H, George. Erectile Dysfun
Page 881 and 882:
Porst H, Giuliano F, Glina S et al.
Page 883 and 884:
Salonia Andrea, Briganti Alberto, M
Page 885 and 886:
Solursh Lionel P, Solursh Diane S.
Page 887 and 888:
van Basten J P, Van Driel M F, Hoek
Page 889 and 890:
Yasumoto R, Nishisaka N, Sakakura T
Page 891 and 892:
Chen J, Godschalk M F, Katz P G et
Page 893 and 894:
Hellstrom W J. Vardenafil: a new ap
Page 895 and 896:
Webb D J, Muirhead G J, Wulff M et
Page 897 and 898:
Kim J M, Joh Y D, Huh J D et al. Do
Page 899 and 900:
Tariq S H, Haleem U, Omran M L et a
Page 901 and 902:
Aizenberg Dov, Gur Shay, Zemishlany
Page 903 and 904:
Beretta G, Marzotto M, Zanollo A et
Page 905 and 906:
Cheng E. Real-life safety and effic
Page 907 and 908:
English J C, King D H C, Foley J P.
Page 909 and 910:
Goldstein I, Auerbach S, Padma-Nath
Page 911 and 912:
Jackson G. Sildenafil (Viagra): New
Page 913 and 914:
Lane B Z, Ausmundson S J, Butler R
Page 915 and 916:
McMahon C G. An attempt to standard
Page 917 and 918:
Mulhall J P, Land S, Parker M et al
Page 919 and 920:
Pohanka M, Kanovsky P, Bares M et a
Page 921 and 922:
Ruof J, Graf-Morgenstern M, Mnller
Page 923 and 924:
Sparwasser C, Treiber U, Bahren W e
Page 925 and 926:
Wagner G, Montorsi F, Auerbach S et
Page 927 and 928:
Anderson R A, Martin C W, Kung A W
Page 929 and 930:
Baggaley M R, Hirst J F, Watson J P
Page 931 and 932:
Buvat J, Boujadoue G. Testosterone
Page 933 and 934:
Contreras L N, Masini A M, Danna M
Page 935 and 936:
Engelhardt P F, Daha L K, Zils T et
Page 937 and 938:
Glasser S P. Safety of PDE 5 inhibi
Page 939 and 940:
Holtkamp M, Weissinger F, Meierkord
Page 941 and 942:
Kirby R S. Report from London. Pros
Page 943 and 944:
Lexchin J. New drugs with novel the
Page 945 and 946:
Mealy N E. Avanafil. Drugs of the F
Page 947 and 948:
Nakata M, Takashima S, Kaminou T et
Page 949 and 950:
Phillips B G, Kato M, Pesek C A et
Page 951 and 952:
Saad F, Grahl A S, Aversa A et al.
Page 953 and 954:
Sipski M, Alexander C, Guo X et al.
Page 955 and 956:
Traish A M, Goldstein I, Kim N N. T
Page 957 and 958:
Wilt T J, Fink H A. Is antidepressa
Page 959 and 960:
Price D E, Cooksey G, Jehu D et al.
Page 961 and 962:
Bolona E R, Uraga M V, Haddad R M e
Page 963 and 964:
Anonymous. Sublingual apomorphine:
Page 965 and 966:
Bouloux P. Testim 1% testosterone g
Page 967 and 968:
Christ B, Brockmeier D, Hauck E W e
Page 969 and 970:
Fein R L. Classification of sexual
Page 971 and 972:
Green B G, Martin S. Clinical asses
Page 973 and 974:
John H, Lehmann K, Hauri D. Intraur
Page 975 and 976:
Lee W R. The role of androgen depri
Page 977 and 978:
Mealy N E. Alprostadil cream. Drugs
Page 979 and 980:
Murphy J C, Srinivas S, Terris M K.
Page 981 and 982:
Pommerville P. Drug treatments for
Page 983 and 984:
Saie D J, Sills E S. Hyperprolactin
Page 985 and 986:
Steidle C P, McCullough A R, Kamine
Page 987 and 988:
Weiss J N, Badlani G H, Ravalli R e
Page 989 and 990:
Anonymous. Study shows patients tak
Page 991 and 992:
Bartlik Barbara D, Kaplan Peter, Ka
Page 993 and 994:
Cawello W, Schweer H, Dietrich B et
Page 995 and 996:
Del Popolo G, Li Marzi V, Mondaini
Page 997 and 998:
Gallo L, Perdona S, Autorino R et a
Page 999 and 1000:
Hofner K, Claes H, De Reijke T M et
Page 1001 and 1002:
Kloner R A, Hutter A M, Emmick J T
Page 1003 and 1004:
Maan Z, Arya M, Shergill I et al. P
Page 1005 and 1006:
Montorsi F, Strambi L F, Guazzoni G
Page 1007 and 1008:
Phelps J S, Jain A, Monga M. The Ps
Page 1009 and 1010:
Sato Y, Suzuki N, Adachi H et al. E
Page 1011 and 1012:
Strachan M W, Teoh W L, Don-Wauchop
Page 1013 and 1014:
Weinhardt L S, Carey M P. Prevalenc
Page 1015 and 1016:
Appendix E. Additional Acknowledgme
Page 1017 and 1018:
Appendix F. Quality AssessmentRando
Page 1019 and 1020:
AuthorYearJadad Q-1 Jadad Q-2 Jadad
Page 1021 and 1022:
AuthorYearJadad Q-1 Jadad Q-2 Jadad
Page 1023 and 1024:
Jadad Q-1AuthorYearJadad Q-2 Jadad
Page 1025:
Quality Assessment of Observational
Page 1029 and 1030:
Appendix G. Funnel PlotsSildenafilF
Page 1031 and 1032:
Figure G-3. Sildenafil (any dose) v
Page 1033 and 1034:
Page 1035 and 1036:
Page 1037 and 1038:
VardenafilAny dose vs. PlaceboFigur
Page 1039 and 1040:
Figure G-11. Vardenafil (any dose)
Page 1041 and 1042:
Figure G-13. Tadalafil (20 mg) vs.
Page 1043 and 1044:
20 mg vs. 10 mgFigure G-15. Tadalaf
Page 1045 and 1046:
Appendix H. Instruments Used in the
Page 1047 and 1048:
1 = Very dissatisfied2 = Moderately
Page 1049 and 1050:
Appendix I. List of Unobtained Arti
show all

Beste apotheek van Nederland

Create successful ePaper yourself

Delete template?

Save as template?