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StudyAdverse EventsTreatmentGroup% (n/N)ControlGroup% (n/N)Absolute RiskDifference[95% CI]Pain on injection07.7–Urethral bleeding2.2–2.5(range)0.4–Priapism0.10–Flushing47.0–50.0(range)Papaverine followed by Sildenafil vs. Sildenafil followed by PapaverineViswaroop 2005Priapism9Both arms combined–HeadacheBlurred visionDyspepsia10.0 (5/50)4.0 (2/50)2.0 (1/50)2.0 (1/50)––––Table 15: Subcutaneous Injection: Improvement in ErectionsTreatment ControlStudy / TypeOutcome Definitionof PatientsMelanotan II vs. PlaceboGroup%(n/N)Group% (n/N)Relative risk (RR)[95% CI]or p valueWessells 2000Psychogenic:10 patientsPhysiologic:10 patientsSubject reported“subjectively apparenterections” on at least oneof two injectionsSubjective erectile activity85.0 (17/20)69.2 (27/39)Based onnumber ofinjectionsNR2.4 (1/41)Based onnumber ofinjections––Analysis: 10patients withphysiologic EDSubject reported“subjectively apparenterections” on at least oneof two injections90.0 (9/10) 10.0 (1/10) 9.00[1.39–58.44]150
Study / Typeof PatientsOutcome DefinitionTreatmentGroup%(n/N)ControlGroup% (n/N)Relative risk (RR)[95% CI]or p valueSubjective erectile activity 63.2 (12/19)Based onnumber ofinjectionsPT–141 (cyclic heptapeptide melanocortin analog) vs. PlaceboRosen 2004NR25 patientswith moderatesevereEDNRwithNRinadequateresponse tosildenafil.4.8 (1/21)Based onnumber ofinjections–Table 16: Subcutaneous Injection: Patients with Adverse EventsStudyAdverse eventTreatmentGroup% (n/N)ControlGroup% (n/N)Melanotan II vs. PlaceboWessells 2000Number ofinjectionsNumber ofinjectionsAbsolute riskdifference (%)[95% CI]Psychogenicandphysiologic EDsubgroupscombinedNausea (any)Nausea (severe)Yawning/stretching (any)38.5 (15/39)15.4 (6/39)56.4 (22/39)9.8 (4/41)2.4 (1/41)12.2 (5/41)Analysis of the10 patientswithphysiologic EDYawning/stretching(severe)Nausea (any)Nausea (severe)7.7 (3/39)42.1 (8/19)21.1 (4/19)0 (0/41)9.5 (2/21)0 (0/21)42.1 (8/19) 0 (0/21)Yawning/stretching (any)15.8 (3/19) 0 (0/21)Yawning/stretching(severe)PT–141 (cyclic heptapeptide melanocortin analog) vs. PlaceboNA151
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This report is based on research co
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This document is in the public doma
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AcknowledgmentsThe authors would li
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ContentsExecutive Summary..........
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Table 17: Intra-urethral Treatment:
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Figure 63. Absolute Mean Change Fro
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associated with ED treatments. Two
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ED as a main complaint. In only one
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different formulations/modes of app
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Evidence Report
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flaccidity are no less important th
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prostatectomy, antipsychotic agents
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disease). Furthermore, there is ins
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Analytic FrameworkFigure 1. Analyti
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KQ 3. Harms of pharmaceutical treat
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Figure 2. Modified QUOROM Flow Char
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that included intervention characte
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Prevalence of Hypogonadism (Total S
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stimulation and a challenge test wi
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Overview of Trials79-84,86-88,90,91
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131,137,138,142,143,147,151,155,156
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pectoris occurred in a participant
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statistical test results for the ob
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individual Q1-Q15 items, 104,106,15
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Proportion of participants with hea
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erectile maintenance frequency, IIE
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Oral Treatments — Phosphodiestera
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Patients were instructed to take th
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Results obtained from two trials 19
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improved erections was higher in pa
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Clinically homogenous groups of pat
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Oral Treatments — Phosphodiestera
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The approximate proportion of smoke
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value was not reported). Even thoug
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Tadalafil (20 mg) versus tadalafil
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scheduled dosing regimen (90 percen
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Proportion of patients with improve
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Sublingual Treatments - Apomorphine
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been taking over the past two or fo
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apomorphine (5 and 6 mg: 38 and 49
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heterogeneity with respect to popul
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Finally, two studies reported on wh
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the second study, prolonged erectio
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Moxisylate versus placebo. One tria
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Quantitative SynthesisThere was a l
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erection” versus one placebo trea
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methods of allocation concealment.
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Prazosin (IU) versus placebo. One t
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reported adequate allocation concea
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Hormonal Treatments Literature Sear
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Harms. In the first trial, the diff
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sex with partner (scale 1-6, with =
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daily for 4 weeks followed by concu
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(MEDQoL) score (range 0-100) compar
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group (16.7, 12.5, and 8.3 percent,
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Question 3a. What Are the harms of
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Chapter 4. DiscussionThis evidence
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Question 1: What is the Clinical Ut
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Questions 2-3: What are the Benefit
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Harms. There were no obvious differ
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alone. Compared with trimix alone,
Page 125 and 126: PhentolamineEfficacy. The results i
Page 127 and 128: Question 2a-b: Do Specific Patient
Page 129 and 130: Methodological and Logistic Limitat
Page 131: Tables and Figures.Summary TablesTa
Page 135: 123Study details 1 Study Design Set
Page 139: 125Table 2: Prevalence of Hypogonad
Page 143: 127Study Details 2 Study Design Set
Page 147: 129Table 4: Prevalence of Hypogonad
Page 151: 131Study Details 5 Study Design Set
Page 155: Table 7: Prevalence of Hyperprolact
Page 159: 135StudyEDDetails 8 Study Design Se
Page 163 and 164: Table 10: Serious Adverse Events in
Page 165 and 166: Table 11: Efficacy Results of Tadal
Page 167 and 168: Treatment Control Relative RiskStud
Page 169 and 170: Treatment Control Relative RiskStud
Page 171 and 172: Table 14: Intracavernosal Injection
Page 173 and 174: StudyAdverse EventsTreatmentGroup%
Page 175: StudyAdverse EventsTreatment Contro
Page 179 and 180: Study ED Etiology OutcomeWilliams*1
Page 181 and 182: Physiologic:60.0 (18/30) 90.0 (27/3
Page 183 and 184: StudyAdverse EventTreatmentGroup% (
Page 185 and 186: TreatmentStudy ED Etiology Group% (
Page 187 and 188: StudyAdverse EventCavallini 1991 Pa
Page 189 and 190: Study/patient CharacteristicsGooma
Page 191 and 192: Aversa 2003Men witharteriogenicEDYa
Page 193 and 194: Study/patientCharacteristicsClopper
Page 195 and 196: Study/patientCharacteristicsOutcome
Page 197 and 198: Table 26: Testosterone Treatment: P
Page 199 and 200: McNicholas2002Patients reporting
Page 201: 175Table 27: Miscellaneous Treatmen
Page 205: 177Table 28: Nonarteritic Anterior
Page 209 and 210: Table 29: Penile Fibrosis in Studie
Page 211 and 212: StudyStudyDesignPatientsage range 4
Page 213 and 214: Figure 6. Improved erection (GEQ-Q1
Page 215 and 216: Figure 11. Visual disturbances (all
Page 217 and 218: Figure 16. Any adverse events (trea
Page 219 and 220: Figure 23. The mean IIEF-Q4 score:
Page 221 and 222: Figure 30. Improved erection (GEQ-Q
Page 223 and 224: Figure 37. Visual disturbances (all
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Figure 49. Dyspepsia (all cause)Fig
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Figure 55. Serious adverse events (
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Figure 61. Mean per-patient percent
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Figure 67. Any adverse events (all-
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Figure 73. Any adverse events (all-
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in men with erectile dysfunction. J
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parameters in obese men with erecti
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comparative crossover study. Androl
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153. Shabsigh R. Efficacy of silden
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190.191.Stief C, Porst H, Saenz dT,
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treatment of men with erectile dysf
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randomized trial. J Urol 1997 Oct;1
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moderate and severe ED. Int J Impot
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349.350.351.randomized, placebo-con
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395. Moher D, Schulz KF, Altman DG.
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PSVRCTRIRIASBPSCSDSETTGTRTWMDpeak s
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dDegDept.Ff/uFHxhrHxIGMmaxminmoNANI
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30. or/24-2931. (ANIMALS not HUMAN)
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27. limit 26 to yr="1990 - 2008"28.
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5. exp clinical trials/6. random$.m
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20. or/17-1921. 16 and 2022. limit
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A systematic review of harms associ
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B-4Summary Table- Randomized Contro
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The Quality Assessment of Studies o
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AuthorFundingN; study design; eligi
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C-10 AuthorFundingN; study design;
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C-146 C5-Intracavernousal Injection
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C-202 C8-Topical Treatments of ED A
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C-216 C9-Testosterone Treatment of
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men with erectile dysfunction and s
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symptoms associated with benign pro
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(84) Zinner N. Do food and dose tim
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(117) Carrier S, Brock GB, Pommervi
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(150) Hagemann JH, Berding G, Bergh
Page 798 and 799:
(183) Moriel EZ, Rajfer J. Sodium b
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(219) Gomaa A, Shalaby M, Osman M e
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(255)(256)dysfunction. Psychopharma
Page 804 and 805:
Adams Henry E, Motsinger Patrice, M
Page 806 and 807:
Althof S E, Turner L A, Levine S B
Page 808 and 809:
Anonymous. Surgery & watchful waiti
Page 810 and 811:
Baker Christine D. A cognitive-beha
Page 812 and 813:
Bayes M, Rabasseda X, Prous J R. Ga
Page 814 and 815:
Bhatnagar V, Stewart S T, Huynh V e
Page 816 and 817:
Boswell-Smith V, Spina D, Page C P.
Page 818 and 819:
Burke J P, Jacobson D J, McGree M E
Page 820 and 821:
Carson C C. Combination of phosphod
Page 822 and 823:
Chen Y. Acupuncture treatment of fu
Page 824 and 825:
Cooke B M, Breedlove S M, Jordan C
Page 826 and 827:
Daitch J A, Angermeier K W, Lakin M
Page 828 and 829:
Derouet H, Jost W H, Osterhage J et
Page 830 and 831:
Doust J, Miller E, Duchesne G et al
Page 832 and 833:
Elhilali M M. Alfuzosin: An a1-rece
Page 834 and 835:
Ferri C, Giuggioli D, Cazzato M et
Page 836 and 837:
Frucht S J. Parkinson disease: An u
Page 838 and 839:
Ghofrani H A, Pepke-Zaba J, Barbera
Page 840 and 841:
Baldwin D S. Sexual dysfunction ass
Page 842 and 843:
Douglass M A, Lin J C. Update on th
Page 844 and 845:
Hatch J P. Psychophysiological aspe
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Lau D H, Mumtaz F H, Thompson C S e
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Morales A, Heaton J P. Hormonal ere
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Roehrborn C G, McNicholas T. The Ma
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Uckert S, Stief C G, Jonas U. Curre
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Leungwattanakij S, Flynn V, Hellstr
Page 856 and 857:
Musacchio Najah S, Hartrich Molly,
Page 858 and 859:
Akkus E, Kadioglu A, Esen A et al.
Page 860 and 861:
Ashok S, Sigman M. Bioavailable tes
Page 862 and 863:
Briganti A, Salonia A, Gallina A et
Page 864 and 865:
Chinegwundoh F, Anie K A. Treatment
Page 866 and 867:
Dundar S O. Visual loss associated
Page 868 and 869:
Giammusso B, Gattuso U, Vanaclocha
Page 870 and 871:
Hawton Keith, Catalan Jose, Fagg Jo
Page 872 and 873:
Kell P. Cardiovascular safety of si
Page 874 and 875:
Laumann Edward O, West Suzanne, Gla
Page 876 and 877:
Matthew A G, Goldman A, Trachtenber
Page 878 and 879:
Mulhall J P. Deciphering erectile d
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Parsons J K, Marschke P, Maples P e
Page 882 and 883:
Rojewski M T, Korper S, Schrezenmei
Page 884 and 885:
Shabsigh R. Testosterone therapy in
Page 886 and 887:
Tam S W, Worcel M, Wyllie M. Yohimb
Page 888 and 889:
Webb D J, Freestone S, Allen M J et
Page 890 and 891:
Katlowitz N M, Albano G J, Morales
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Sparwasser C, Treiber U, Bahren W e
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van Basten J P, Van Driel M F, Jonk
Page 896 and 897:
Youssef A F, Fort F L, Ronsen B et
Page 898 and 899:
Cooper A J. Evaluation of I-C papav
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Isidori A M, Giannetta E, Gianfrill
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Armstrong D K, Convery A, Dinsmore
Page 904 and 905:
Buvat J, Montorsi F. Safety and tol
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De Rose A F, Giglio M, Traverso P e
Page 908 and 909:
Gana T E, Quizanos L F, Castell R e
Page 910 and 911:
Hatzichristou D G, Apostolidis A, T
Page 912 and 913:
Kim E D, McVary K T. Topical prosta
Page 914 and 915:
Lundberg L, Olsson J-O, Kihl B. Lon
Page 916 and 917:
Moncada I, Jara J, Subira D et al.
Page 918 and 919:
Ohebshalom M, Parker M, Guhring P e
Page 920 and 921:
Rajpurkar A, Dhabuwala C B. Compari
Page 922 and 923:
Shabsigh R. Hypogonadism and erecti
Page 924 and 925:
Terradas C, Levalle O, Nagelberg A
Page 926 and 927:
Yenicerioglu Y, Kefi A, Aslan G et
Page 928 and 929:
Anonymous. New erectile dysfunction
Page 930 and 931:
Bolona E R, Uraga M V, Haddad R M e
Page 932 and 933:
Chen J, Greenstein A, Kaver I et al
Page 934 and 935:
Derby C A, Barbour M M, Hume A L et
Page 936 and 937:
Foulks C J, Cushner H M. Sexual dys
Page 938 and 939:
Hamed S, Mohamed K, El-taher A et a
Page 940 and 941:
Jeong S-J, Park K, Moon J-D et al.
Page 942 and 943:
La Pera G, Franco Giannotti C, Tagg
Page 944 and 945:
Mann R D. Introduction - Tadalafil.
Page 946 and 947:
Montorsi F, Burnett A L. Erectile d
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Ozdel O, Oguzhanoglu A, Oguzhanoglu
Page 950 and 951:
Ramasubbu Rajamannar. Switching to
Page 952 and 953:
Schwartz E J, Wong P, Graydon R J.
Page 954 and 955:
Stolk E A, Busschbach J J, Caffa M
Page 956 and 957:
Vitezic D. A risk-benefit assessmen
Page 958 and 959:
Bancroft J, Smith G, Munoz M et al.
Page 960 and 961:
Knispel H H, Huland H. Influence of
Page 962 and 963:
Padma-Nathan H, Eardley I, Kloner R
Page 964 and 965:
Bai W J, Zhu J C, Jiang H et al. [A
Page 966 and 967:
Carosa E, Martini P, Brandetti F et
Page 968 and 969:
Doggrell S A. Comparison of clinica
Page 970 and 971:
Gingell C, Buvat J, Jardin A et al.
Page 972 and 973:
Heaton J P, Morales A, Adams M A et
Page 974 and 975:
Kloner R A, Mitchell M, Emmick J T.
Page 976 and 977:
Marks L S, Duda C, Dorey F J et al.
Page 978 and 979:
Montorsi F, Guazzoni G, Bergamaschi
Page 980 and 981:
Padma-Nathan H, Goldstein I, Klimbe
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Reznik I, Zemishlany Z, Kotler M et
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Shamloul Rany, Kamel Ihab, E-Mail A
Page 986 and 987:
Tsujimura A, Yamanaka M, Takahashi
Page 988 and 989:
Zippe C D, Kedia A W, Kedia K et al
Page 990 and 991:
Anonymous. Diagnostic and therapeut
Page 992 and 993:
Briganti A, Chun F K H, Salonia A e
Page 994 and 995:
Clough J. CNS-targeted sexual dysfu
Page 996 and 997:
Emilien G. Alprox-TD NexMed Inc. Cu
Page 998 and 999:
Gryglewska B, Grodzicki T. Betaxolo
Page 1000 and 1001:
Kadioglu A, Erdogru T, Tellaloglu S
Page 1002 and 1003:
Lebret T, Herve J M, Gorny P et al.
Page 1004 and 1005:
Mealy N E. GPI-1485. Drugs of the F
Page 1006 and 1007:
O'Sullivan J D. Apomorphine as an a
Page 1008 and 1009:
Riley Alan. Oral treatments for ere
Page 1010 and 1011:
Silvestri A, Galetta P, Cerquetani
Page 1012 and 1013:
Unnikrishnan A G, Rajaratnam S, Ses
Page 1014 and 1015:
Zhao L. Clinical observation on the
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The UO-EPC gratefully acknowledges
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AuthorYearHellstrom 2005 37 Jadad Q
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AuthorYearJadad Q-1 Jadad Q-2 Jadad
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AuthorTotal AllocationJadad Q-1 Jad
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AuthorYearSaylan 2006 265 Jadad Q-1
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F-10STUDY IDQ1:SpectrumQ2.Selection
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Figure G-2. Sildenafil (any dose) v
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Figure G-8. Sildenafil (25 mg) vs.
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Figure G-10. Vardenafil (any dose)
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Tadalfil20 mg vs. PlaceboFigure G-1
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Figure G-14. Tadalafil (20 mg) vs.
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Figure G-16. Tadalafil (20mg) vs. T
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5 = Eleven+ attempts Q7: When you a
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The IIEF-5 score is the sum of ques
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El Malik EMA. Erectile dysfunction:
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