Mass Spectrometry - Faculté de médecine de l'université d'Ottawa
Mass Spectrometry - Faculté de médecine de l'université d'Ottawa
Mass Spectrometry - Faculté de médecine de l'université d'Ottawa
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Relative abundance<br />
A) <strong>Mass</strong> spectrum of unfol<strong>de</strong>d cytochrome c leading to higher charge states from a higher <strong>de</strong>gree of<br />
protonation (most abundant charge state has 16 positive charges on it). B) <strong>Mass</strong> spectrum of cytochrome<br />
c in a more native, fol<strong>de</strong>d conformation resulting in less protonation (8 or 9 positive charges on it).<br />
(Adapted from Konermann, L., Collings, B.A., Douglas, D.J. Cytochrome c folding kinetics studied by timeresolved<br />
electrospray ionization mass spectrometry. Biochemistry 36, 5554-5559 (1997)).<br />
11/21/2005 24<br />
Relative abundance