Mass Spectrometry - Faculté de médecine de l'université d'Ottawa
Mass Spectrometry - Faculté de médecine de l'université d'Ottawa
Mass Spectrometry - Faculté de médecine de l'université d'Ottawa
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Proposed MALDI mechanisms:<br />
1. Primary ionization mechanisms<br />
i. Multiphoton ionization<br />
ii. Energy pooling and multicenter mo<strong>de</strong>ls<br />
iii. Excited-state proton transfer (ESPT)<br />
iv. Disproportionation reactions<br />
v. Desorption of pre-formed ions<br />
vi. Thermal ionization<br />
2. Secondary ionization mechanisms<br />
i. Gas-phase proton transfer<br />
ii. Gas-phase cationization<br />
iii. Electron transfer<br />
MALDI is likely a combination of many of these<br />
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