Lentiviral Vectors: design, production, and titration
Lentiviral Vectors: design, production, and titration
Lentiviral Vectors: design, production, and titration
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HIV provirus<br />
LTR<br />
ψ SD<br />
Gag<br />
Pro<br />
2 nd Generation vector<br />
DU3 R U5<br />
RSV<br />
DU3 R U5<br />
Pol<br />
Vif<br />
R<br />
U<br />
Tat<br />
Rev<br />
Env<br />
<strong>Lentiviral</strong> Vector Systems<br />
Requires Tat for <strong>production</strong><br />
3rd Generation vector<br />
Constitutive promoter<br />
RSV or CMV<br />
Tat is not required<br />
RRE<br />
Nef<br />
∆<br />
LTR<br />
SIN<br />
∆U3 R U5<br />
SIN<br />
∆U3 R U5
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