Antibiotic Classification and Modes of Action - bioMerieux
Antibiotic Classification and Modes of Action - bioMerieux
Antibiotic Classification and Modes of Action - bioMerieux
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Customer Education <strong>Antibiotic</strong> <strong>Classification</strong><br />
Interpreting Susceptibility Results<br />
• MICs are not physical measurements<br />
• There are many factors that play a role<br />
in determining clinical outcome<br />
• Susceptibility in vitro does not uniformly<br />
predict clinical success in vivo<br />
• Resistance will <strong>of</strong>ten, but not always,<br />
correlate with treatment failure<br />
Susceptibility tests are essentially artificial measurements.<br />
� in vitro response<br />
� approximate range <strong>of</strong> effective inhibitory action<br />
� possible error equivalent to one tube dilution<br />
The only true measure <strong>of</strong> bacterial response to an antibiotic is the clinical<br />
response <strong>of</strong> the patient.<br />
� outcome or in vivo response<br />
One <strong>of</strong> the real values <strong>of</strong> AST is to predict resistance<br />
S = success likely, but no guarantee<br />
R = correlates well with treatment failure<br />
Is Resistance Testing a better name for what we do than Susceptibility<br />
Testing?<br />
© bioMérieux, Inc., Customer Education<br />
March 2008<br />
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