Antibiotic Classification and Modes of Action - bioMerieux
Antibiotic Classification and Modes of Action - bioMerieux
Antibiotic Classification and Modes of Action - bioMerieux
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Customer Education <strong>Antibiotic</strong> <strong>Classification</strong><br />
Outer<br />
Membrane<br />
Peptido -<br />
glycan<br />
Cytoplasmic<br />
Membrane<br />
2. Inhibitors <strong>of</strong> Protein Synthesis<br />
Entry <strong>of</strong> MLSK in Gram-Negative Bacteria<br />
MLSK<br />
PBP<br />
Porin<br />
© bioMérieux, Inc., Customer Education<br />
March 2008<br />
Endotoxin =<br />
LPS<br />
β-lactamase<br />
• In Gram-negative bacteria there is no entry because MLSK are lipophilic<br />
molecules. They cannot cross the outer membrane which is hydrophilic.<br />
“Oil <strong>and</strong> water don’t mix”.<br />
• MLSK are also large molecules that cannot pass through the porins (which<br />
are also aqueous channels) – impermeability.<br />
• Most Gram-negatives are naturally resistant to MLSK<br />
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