Antibiotic Classification and Modes of Action - bioMerieux

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Customer Education Antibiotic Classification Outer Membrane Peptido - glycan Cytoplasmic Membrane Quinolone Mode of Action 5. Inhibitors of Nucleic Acid Synthesis Entry of Quinolones Quinolones • Small and hydrophilic, quinolones have no problem crossing the outer membrane. • They easily diffuse through the peptidoglycan and the cytoplasmic membrane and rapidly reach their target. • Target = Topoisomerases, e.g., DNA-gyrase • Rapid bactericidal activity © bioMérieux, Inc., Customer Education March 2008 90
Customer Education Antibiotic Classification 5. Inhibitors of Nucleic Acid Synthesis Circular Bacterial DNA Supercoiling of DNA Coiled by DNA Gyrase © bioMérieux, Inc., Customer Education March 2008 Fits inside the bacterial cell • The bacterial chromosome is supercoiled by the enzyme DNA gyrase • A fully supercoiled chromosome will be about 1 micron in diameter - small enough to fit in the bacteria • The bacterial chromosome consists of a single circle of DNA • DNA is double-stranded forming a left-handed double helix • A typical E. coli’s chromosome is 1400 microns long • The E. coli’s bacterial cells are 2-3 microns long 91
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Antibiotic Classification and Modes of Action - bioMerieux

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