Antibiotic Classification and Modes of Action - bioMerieux
Antibiotic Classification and Modes of Action - bioMerieux
Antibiotic Classification and Modes of Action - bioMerieux
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Customer Education <strong>Antibiotic</strong> <strong>Classification</strong><br />
Beta-lactams International Common Name<br />
Monobactams<br />
Penems<br />
1. Inhibitors <strong>of</strong> Cell Wall Synthesis<br />
Carbapenems<br />
Penems<br />
Inhibitors <strong>of</strong> Cell Wall Synthesis<br />
Beta-lactams: Monobactams<br />
Aztreonam<br />
Imipenem<br />
Meropenem<br />
Ertapenem<br />
Doripenem<br />
Faropenem<br />
Spectrum <strong>of</strong> <strong>Action</strong><br />
• Aztreonam: Gram-negatives (Enterobacteriaceae <strong>and</strong><br />
Pseudomonas). Not hydrolyzed by most commonly occurring<br />
plasmid <strong>and</strong> chromosomally mediated ß-lactamases, <strong>and</strong> does not<br />
induce the production <strong>of</strong> these enzymes.<br />
Beta-lactams: Penems<br />
Slightly different structure than the other ß-lactams, make the Penems<br />
much more resistant to beta-lactamase hydrolysis.<br />
Spectrum <strong>of</strong> <strong>Action</strong><br />
• Carbapenems: ß-lactams with a broad spectrum <strong>of</strong> action. Grampositives,<br />
except MRSA. Gram-negatives, Ps. aeruginosa (except<br />
Ertapenem) <strong>and</strong> anaerobes. Very efficient against high level<br />
cephalosporinase <strong>and</strong> ESBL. Wide diffusion in the body, especially<br />
in the cerebrospinal fluid.<br />
Doripenem (new) - Broad spectrum. Particularly good for<br />
Pseudomonas <strong>and</strong> other non-fermenters.<br />
• Penem: Oral. Primarily for respiratory tract infections. Poor activity<br />
with Serratia, Pseudomonas, Stenotrophomonas.<br />
Faropenem not yet FDA approved.<br />
© bioMérieux, Inc., Customer Education<br />
March 2008<br />
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