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152 153 Intestinal Disease Meeting Berlin 2006 - Dr. Falk Pharma ...

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Session 2<br />

Role of Endoscopy<br />

Chair:<br />

J. Devière, Brussels<br />

H. Lochs, <strong>Berlin</strong><br />

Gastroesophageal reflux disease –<br />

Will tomorrow’s therapy be<br />

endoscopic?<br />

According to J. Mössner (Leipzig), endoscopy<br />

plays a central role in the diagnosis of gastroesophageal<br />

reflux disease (GERD), although only<br />

about 50% of GERD patients actually exhibit<br />

endoscopically recognizable lesions in the esophagus.<br />

Obtaining a baseline examination early in<br />

the disease is important and provides a basis for<br />

assessing the subsequent disease course, as well<br />

as for work-up of a Barrett’s esophagus. In addition,<br />

an emergent endoscopic examination is indicated<br />

in any patient reporting alarm systems<br />

Fig. 11<br />

I Barrett’s esophagus (J. Mössner, Leipzig)<br />

Congress Short Report <strong>Falk</strong> Symposium <strong>152</strong><br />

J. Mössner<br />

such as dysphagia, weight loss or hemorrhage.<br />

Finally, patients with reflux symptoms who do<br />

not respond promptly to standard therapy with<br />

a proton pump inhibitor (PPI) represent a further<br />

indication for endoscopy.<br />

According to J. Mössner, the role of the newer<br />

techniques, such as chromoendoscopy, zoom<br />

endoscopy and narrow band imaging for the diagnosis<br />

of GERD cannot be definitively assessed<br />

at this time. However, he does expect significant<br />

progress from the application of high-resolution<br />

endoscopy in the identification of high-grade<br />

dysplasias and early carcinomas in patients with<br />

Barrett’s esophagus (figure 11). In this area, he<br />

13

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