152 153 Intestinal Disease Meeting Berlin 2006 - Dr. Falk Pharma ...

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Session 1 30 Fig. 20 A B C P. Marteau Does the intestinal flora itself trigger Crohn’s disease? Beside the immune system, the bacteria of the gastrointestinal tract play a role in the pathogenesis of Crohn’s disease. In the presence of a genetically determined susceptibility the intestinal A: Listeria monocytogenes; B: Measles C. Mycobacterium paratuberculosis; D: Saccharomyces I Crohn’s disease and pathogens? Conflicting results (P. Marteau, Paris) flora can actually directly promote inflammation. According to P. Marteau (Paris), bacteria exert physiological effects on the mucosal structure, epithelial turnover, the development of immune reactions and even on intestinal function. These reactions are mediated through the TLRs and the NOD2 system. This explains why changes in the intestinal flora can result in changes on the immunological level. According to P. Marteau, discussion has centered on the involvement of numerous bacterial species (figure 20), and there is evidence that there may be differences between Crohn’s disease and ulcerative colitis. While involvement by intestinal flora seems most pronounced in Crohn’s disease, it may be considerably less so in ulcerative colitis. D
Session 2 Optimization in Therapy Through Improved Disease Classification? Chair: M. Gasull, Badalona H. Goebell, Essen Classification of the clinical phenotype – pros and cons Just as there are controversies regarding the exact pathogenesis of IBD, there is also disagreement on the best classification of these two disease entities. W. Reinisch (Vienna) argued for a classification by clinical phenotype: “The clinical phenotype is the fastest and most objective means of assessing the disease.” However, the claim of different classification schemas to describe the disease according to objective and reproducible criteria is, W. Reinisch said, hardly more than a “wish list” that “is out of touch with reality”. Similarly, there is no standard Congress Short Report Falk Symposium 153 W. Reinisch method for the diagnosis of IBD. “We are actually confronted more with a diagnostic puzzle,” W. Reinisch said. Important components include the clinical evaluation in combination with the endoscopic, histological and radiological findings, as well as the results of laboratory studies. W. Reinisch also criticized the so-called Vienna Classification, which, among other factors, also takes into account the localization and clinical course of the disease. Both can be variable and are not, in his opinion, suitable for describing the disease. 31
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Page 7 and 8: (Düsseldorf) cited the development
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Page 21 and 22: Session 4 Gastrointestinal Oncology
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Page 27 and 28: Interview Interview with Professor
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Page 35 and 36: Fig. 22 CDP571 34 21 Placebo I CRP
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Page 39 and 40: Fig. 26 % of relapse 70 60 50 40 30
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152 153 Intestinal Disease Meeting Berlin 2006 - Dr. Falk Pharma ...

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