Partec Reagents & mAb Catalog

sPecificity format order no. Qty isotyPe clone reactivity examPle
cd21 Purified 05-7-156 100µg IgG1 LT 21 Hu, Por, Bo, Can
FITC 05-7-156F 1 ml*
PE 05-7-156P 1 ml*
APC 05-7-156A 1 ml*
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CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its
breakdown fragments, which remain covalently attached to complement activating
surfaces or antigens. CD21 has important roles in uptake and retention of immunocomplexes,
survival of memory B cells and in development and maintenance of the humoral
response to T dependent antigens. CD21 also serves as a key receptor for Epstein-Barr
virus binding and is involved in targeting prions to folicular dendritic cells and expediting
neuroinvasion following peripheral exposure to prions. A soluble form of the CD21
(sCD21) is shed from the lymphocyte surface and retains its ability to bind respective
ligands.
The antibody LT21 reacts with CD21 (CR2), a 145 kDa transmembrane glycoprotein
(complement C3d receptor – C3dR) expressed on B lymphocytes, follicular dendritic
cells, some epithelial cells and a subset of T lymphocytes. It is not expressed on immature
B cells.
cd22 Purified 05-7-157 100 µg IgG1 MEM-01 Hu, Pri
FITC 05-7-157F 1 ml*
PE 05-7-157P 1 ml*
APC 05-7-157A 1 ml*
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CD22, also known as Siglec-2 (sialic acid-binding immunoglobulin-like lectin-2) is
a transmembrane glycoprotein binding alpha2,6-linked sialic acid-bearing ligands.
Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the
immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a threshold for B
cell receptor-mediated activation. CD22 also regulates B cell response by involvement
in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway
and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway.
The antibody MEM-01 reacts with CD22 (BL-CAM), a 130 kDa type I transmembrane
glycoprotein (immunoglobulin superfamily) expressed in the cytoplasm of pro-B and
pre-B lymphocytes, and on the surface of mature and activated B lymphocytes; it is lost
on plasma cells, peripheral blood T lymphocytes, granulocytes and monocytes. The
antibody MEM-01 cross-blocks the antibody OTH228 that recognises uniquely epitope
"E"; it does not cross-block antibodies RFB-4, CLB22/1 and CLB- BLy1.
*for 50 tests
Hu: human, Ms: mouse, Pri: primate, Por: porcine, Bo: bovine, Can: canine
List of mouse monoclonal antibodies
15