Partec Reagents & mAb Catalog

sPecificity format order no. Qty isotyPe clone reactivity examPle
cd62l Purified 05-7-201 1 ml* IgG1 LT-TD180 Hu
FITC 05-7-201F 1 ml*
PE 05-7-201P 1 ml*
APC 05-7-201A 1 ml*
FITC F05-7-513F 1 ml* IgG1 HI62L Hu
comment
CD62L (L-selectin) is an adhesion glycoprotein that is constitutively expressed on the
cell surface of leukocytes and mediates their homing to inflammatory sites and peripheral
lymph nodes by enabling rolling along the venular wall. CD62L is also involved
in activation-induced neutrophil aggregation. Activation-dependent CD62L shedding,
however, counteracts neutrophil rolling. CD62L has also signaling roles including enhance
of chemokine receptor expression. Similarly to CD62P, the major ligand of CD62L
is PSGL-1 (P-selectin glycoprotein ligand-1).
The antibody LT-TD180 reacts with CD62L (L-selectin), a 74-95 kDa single chain type I
glycoprotein expressed on most peripheral blood B lymphocytes, T lymphocytes, monocytes
and granulocytes; it is also present on a subset of NK cells and certain haematopoietic
malignant cells.
The antibody HI62L recognises a 76 kDa type I glycoprotein, L-selectin, also called
leucocyte endothelial cellular adhesion molecule-1 (LECAM-1). CD62L is expressed on
most peripheral blood T cells, B cells, some NK cells, monocytes and neutrophils; it
is also present on some splenic lymphocytes, bone marrow lymphocytes and myeloid
cells, thymocytes and certain haematopoietic malignant cells. CD62L acts as the
peripheral lymph node homing receptor, mediates lymphocytes homing to high endothelial
venules (HEV) of peripheral lymphoid tissue and leucocytes rolling on activated
endothelium at inflammatory sites.
cd62P FITC 05-7-203F 1 ml* IgG1 HI62P Hu
PE 05-7-203P 1 ml*
APC 05-7-203A 1 ml*
comment
CD62P (P-selectin) is an adhesion glycoprotein that is expressed on platelets and
endothelial cells upon their activation. Interaction between CD62P and its mucin-like
ligand PSGL-1 (P-selectin glycoprotein ligand-1) expressed on the microvilli of most
leukocytes supports leukocyte rolling along postkapillary venules at the earliest time of
inflammation. Both CD62P and PSGL-1 are extended glycoproteins that form homodimers.
CD62P dimerisation is probably mediated through interactions of the transmembrane
domains and stabilises leukocyte tethering and rolling, probably by increasing
rebinding within a bond cluster.
The antibody HI62P recognises CD62P (P-selectin), a 140 kDa single chain type I
transmembrane glycoprotein present in secretory α-granules in platelets, in Weibel-
Palade bodies in endothelial cells and in megakaryocytes; it is relocated to the plasma
membrane upon activation.
*for 50 tests
Hu: human, Ms: mouse, Pri: primate, Por: porcine, Bo: bovine, Can: canine
List of mouse monoclonal antibodies
27