Partec Reagents & mAb Catalog

sPecificity format order no. Qty isotyPe clone reactivity examPle
cd139 FITC 05-7-467F 1 ml* IgG1 BU30 Hu
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CD139 is found on peripheral blood cells, monocytes, granulocytes and is weakly expressed
on erythrocytes. Shows some reactivity with the smooth muscle of some blood
vessels.
The monoclonal antibody BU30 reacts with the 228 kDa CD139 antigen under native
(non-reducing) conditions. Histologically, there is a strong reactivity with renal glomeruli
and follicular dendritic cells.
cd147 Purified 05-7-217 100 µg IgG1 MEM-M6/1 Hu
FITC 05-7-217F 1 ml*
PE 05-7-217P 1 ml*
APC 05-7-217A 1 ml*
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CD147 (basigin, neurothelin, OX-47, 5A11, CE9, M6) also known as EMMPRIN (extracellular
matrix metalloproteinase inducer) or TCSF (tumour cell-derived collagenasestimulatory
factor) is an ubiquitously expressed cell surface protein with multiple glycosylated
forms. The highest level of CD147 expression is on metabolically active cells,
such as lymphoblasts, inflammatory cells, brown adipocytes and malignant tumour
cells. CD147 has multiple functions, including facilitating of cell surface expression of
monocarboxylate transporter proteins and extracellular matrix metalloproteinases,
regulation of integrin functions, it plays roles in cell development and activation, fetal
development or retinal function.
The antibody MEM-M6/1 recognises an epitope in the N-terminal Ig domain (D1)
of CD147 (Neurothelin), a 50-60 kDa type I transmembrane glycoprotein primarily
expressed on all leukocytes, red blood cells, platelets and endothelial cells; it is not
expressed by resting lymphocytes. The antibody MEM-M6/1 is a high-affinity antibody
capable of binding to unstimulated peripheral blood T cells.
cd177 FITC 05-7-221F 1 ml* IgG1 MEM-166 Hu, Pri
PE 05-7-221P 1 ml*
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CD177 (NB1/HNA-2a and PRV-1 form) is a GPI-anchored glycoprotein present mainly
on neutrophils. Its plasma membrane expression is increased during pregnancy and
inflammation or after G-CSF application. Ligand of CD177 has been identified as CD31
(PECAM-1). CD177 participates in neutrophil transmigration and seems to be also a
pro-proliferative molecule. The antibodies against CD177 can be involved in neonatal
alloimmune neutropenia (NAN).
The antibody MEM-166 reacts with CD177 (Neutrophil specific antigen 1), a 60 kDa GPIlinked
cell surface glycoprotein of uPAR family, expressed on granulocytes and in bone
marrow early erythroblasts, megakaryocytes, promyelocytes and myelocytes.
*for 50 tests
Hu: human, Ms: mouse, Pri: primate, Por: porcine, Bo: bovine, Can: canine
List of mouse monoclonal antibodies
33