Partec Reagents & mAb Catalog

sPecificity format order no. Qty isotyPe clone reactivity examPle
cd4 Purified 05-7-390 100 µg IgG2a EDU-2 Hu
FITC 05-7-390F 1 ml*
PE 05-7-390P 1 ml*
PE-Dy647 05-7-390 PD 647 1 ml*
APC 05-7-390A 1 ml*
Purified 05-7-128 100 µg IgG1 MEM-241 Hu
FITC 05-7-128F 1 ml*
PE 05-7-128P 1 ml*
PE-Dy647 05-7-128 PD 647 1 ml*
APC 05-7-128A 1 ml*
FITC 05-7-504F 1 ml* IgG2b HIT4a Hu
PE 05-7-504P 1 ml*
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CD4 is a single chain transmembrane glycoprotein belonging to the immunoglobulin
superfamily. It has 4 immunoglobulin domains (1 Ig-Like V-type and 3 Ig-like C2- Type).
The intracellular domain of CD4 is associated with p56Lck, a Src-like protein tyrosine
kinase. It was described, that CD4 segregates into specific detergent-resistant T cell
membrane microdomains. CD4 is a co-receptor involved in immune response (coreceptor
activity in binding to MHC class II molecules) and HIV infection (human immunodeficiency
virus; CD4 is a primary receptor for HIV-1 surface glycoprotein gp120). CD4
regulates T cell activation, T/B cell adhesion, T- cell differentiation, T cell selection and
signal transduction. Defects in antigen presentation (MHC classII) cause dysfunction
of CD4+ T cells and their almost complete absence in patients blood, tissue and organs
(SCID immunodefiency).
The antibody MEM-241 recognises the CD4 antigen, a 55 kDa transmembrane glycoprotein
expressed on a subset of T cells (helper T cells) and also on monocytes, tissue
macrophages and granulocytes.
The antibody EDU-2 recognises the CD4 antigen, a 55 kDa transmembrane glycoprotein
expressed on a subset of T lymphocytes (“helper” T cells) and also on monocytes, tissue
macrophages and granulocytes.
for in-vitro diagnostic use
cd5 FITC 05-7-397F 1 ml* IgG1 LT1 Hu
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CD5 is present on all mature T lymphocytes, on most thymocytes and on many T
cell leukaemias and lymphomas. It reacts with a subpopulation of activated B cells.
CD5/LT1 antigen is a monomeric type I transmembrane glycoprotein expressed on
thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer
(NK) cells. It has been identified as the major ligand of the B cell antigen CD72. The
frequency of CD5+ B cells exhibites strain dependent variation, and the phenotypic, anatomical,
functional, developmental, and pathological characteristics of the CD5+ B cells
suggest that they may represent a distinct lineage, known as B1 cells. Binding of CD5 on
the T cell surface can augment alloantigen or mitogen induced lymphocyte proliferation
and induces increased cytosolic free calcium, IL2 secretion, and IL2R expression. It has
been proposed that CD5 negatively regulates signal transduction mediated by the T cell
and B cell receptors.
The antibody LT1 reacts with the cell surface glycoprotein CD5, a 67kDa single-chain
transmembrane glycoprotein expressed on mature T-lymphocytes, most of thymocytes
and B-lymphocytes subset (subset 1a).
*for 50 tests
Hu: human, Ms: mouse, Pri: primate, Por: porcine, Bo: bovine, Can: canine
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List of mouse monoclonal antibodies
ssc Analysed with CyFlow ®
Pe cd4
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0.1 1 10 100 1000
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