Partec Reagents & mAb Catalog

sPecificity format order no. Qty isotyPe clone reactivity examPle
cd45rb
cd45ro
FITC 05-7-183F 1 ml* IgG1 MEM-55 Hu
PE 05-7-183P 1 ml*
APC 05-7-183A 1 ml*
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CD45RB is a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is
crucial in lymphocyte development and antigen signaling, serving as an important regulator
of Src-family kinases. It promotes cell survival by modulating integrin-mediated
signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
CD45 isoforms differ in their extracellular domains, whereas they share identical
transmembrane and cytoplasmic domains. These isoforms differ in their ability to
translocate into the glycosphingolipid-enriched membrane domains and their expression
depends on cell type and physiological state of the cell. CD45RB is expressed e.g.
in microglia and inflammatory cells.
The antibody MEM-55 recognises a siliadase-sensitive epitope of CD45RB, a 180-240
kDa single chain type I membrane glycoprotein, variant of CD45 (CD45RB isoform).
CD45RB is expressed on a subset of T lymphocytes, B lymphocytes, monocytes, macrophages,
granulocytes and dendritic cells.
FITC 05-7-436F 1 ml* IgG2a UCHL1 Hu
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CD45R0 is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45
glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving
as an important regulator of Src-family kinases, promotes cell survival by modulating
integrin-mediated signal transduction pathway and is also involved in DNA fragmentation
during apoptosis. CD45 isoforms differ in their extracellular domains, whereas
they share identical transmembrane and cytoplasmic domains. These isoforms differ
in their ability to translocate into the glycosphingolipid-enriched membrane domains
and their expression depends on cell type and physiological state of the cell. CD45R0
is expressed e.g. on macrophages, CD8+ T cells, activated T cells and myeloma cells.
CD45RO
The antibody UCHL1 recognises CD45RO, a 180 kDa low molecular weight isoform of
the leukocyte common antigen (LCA). The antigen is expressed on a subset of memory/
activated T cells and on cortical thymocytes.
cd49d FITC 05-7-469F 1 ml* IgG1 BU49 Hu
PE 05-7-469P 1 ml*
APC 05-7-469A 1 ml*
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CD49d is the receptor for VCAM-1, thrombospondin and fibronectin. It plays a role in
ECM adhesion and in the movement and migration of lymphocyte subsets within the
circulatory system. This makes CD49d clinically useful in studies of inflammatory
responses, distribution of haematopoietic stem cells and tumour metastatic dispersement.
The antibody BU49 reacts with the kD VLA-alpha-4 chain (lymphocyte homing receptor),
which is associated with the CD29 molecule in the VLA-4 complex. This complex stimulates
(or co-stimulates) specific tyrosine phosphorylation on focal adhesion kinase,
paxillin, p59fy/p56lck and other moieties. The antigen is expressed on ALL and AML
cells, T and B cells, monocytes, thymocytes and Langerhans cells.
The antibody does not react with human kidney or brain sections, but positively stains
malignant melanoma cells.
*for 50 tests
Hu: human, Ms: mouse, Pri: primate, Por: porcine, Bo: bovine, Can: canine
List of mouse monoclonal antibodies
23