Partec Reagents & mAb Catalog

sPecificity format order no. Qty isotyPe clone reactivity examPle
cd97 Purified 05-7-211 100 µg IgG1 MEM-180 Hu
FITC 05-7-211F 1 ml*
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CD97 is a G-protein-coupled seven-span transmembrane adhesive receptor that is constitutively
expressed on granulocytes and monocytes and rapidly upregulated on T and
B cells upon activation. CD97 is produced in alternatively spliced forms and its cellular
ligand is CD55 (DAF), which protects various cell types from complement-mediated
damage. Interaction of CD97 on leukocytes and CD55 on vessel cells probably facilitate
leukocyte activation and migration into the tissues, similarly, CD97 seems to play a role
in tumour migration and invasiveness. CD97 is involved in T cell regulation and peripheral
granulocyte homeostasis.
The antibody MEM-180 recognises an unique epitope on CD97, a 75-85 kDa surface
glycoprotein of G-protein-coupled receptor family, expressed on activated B and T lymphocytes,
monocytes/macrophages, dendritic cells and granulocytes.
cd98 Purified 05-7-212 100 µg IgG1 MEM-108 Hu
FITC 05-7-212F 1 ml*
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CD98 (4F2) is a type II transmembrane glycoprotein which serves as the heavy chain of
the heterodimeric amino acid transporters (HATs). CD98, linked to various light chains
by disulfide bond, is responsible for cell surface expression and basolateral localization
of this transporter complex in polarised epithelial cells and also interacts with β1
integrins and increases their affinity for ligand. Besides its roles in amino acid transport,
CD98 is thus involved in cell fusion and activation. It is implicated in regulation of
cellular differentiation, growth and apoptosis.
The antibody MEM-108 reacts with CD98, a 125 kDa disulfide-linked heterodimer (80
kDa glycosylated heavy chain + 45 kDa non-glykosylated light chain). CD98 is expressed
on T lymphocytes (upon activation) and activated NK cells; it is also present at low
levels on B lymphocytes, NK cells, monocytes and platelets.
cd99r Purified 05-7-213 100 µg IgGM MEM-131 Hu
FITC 05-7-213F 1 ml*
comment
CD99 (E2, MIC2) is a transmembrane glycoprotein that is involved in regulation of T
cell addhesive properties and programmed cell death distinct from typical apoptosis
course. CD99 roles are specific to certain stages of T cell differentiation such as corticothymocytes.
CD99R isoform expression is restricted in the haematopoietic system to
T, NK and myeloid cells.
The antibody MEM-131 reacts with CD99R, an epitope restricted to a subset of CD99
molecule expressed on myeloid cells, NK cells and T lymphocytes.
*for 50 tests
Hu: human, Ms: mouse, Pri: primate, Por: porcine, Bo: bovine, Can: canine
List of mouse monoclonal antibodies
31