14.06.2013 Views

HEMOPATIAS MALIGNAS - Instituto de Oncología Ángel H. Roffo

HEMOPATIAS MALIGNAS - Instituto de Oncología Ángel H. Roffo

HEMOPATIAS MALIGNAS - Instituto de Oncología Ángel H. Roffo

SHOW MORE
SHOW LESS

Create successful ePaper yourself

Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.

378 PAUTAS DE DIAGNOSTICO Y TRATAMIENTO / INSTITUTO ANGEL H. ROFFO<br />

CLORAMBUCILO + PREDNISONA<br />

CLORAMBUCILO 0.3 mg/kg VO Días 1 al 5<br />

PREDNISONA 40 mg/m 2 VO Días 1 al 5<br />

Ciclos cada 28 días<br />

CVP<br />

CICLOFOSFAMIDA 750 mg/m 2 IV Día 1<br />

VINCRISTINA 1.4 mg/m 2 IV Día 1<br />

PREDNISONA 100 mg VO Días 1 al 5<br />

Ciclos cada 28 días<br />

BIBLIOGRAFIA<br />

79. Crespo M, Bosch F, Villamar N, e al. ZAP-<br />

70 expression as a surrogate for immunoglobulinvariable-region<br />

mutations in chronic lymphocytic<br />

leucemia. N Eng J Med 2003; 348: 1764-1775.<br />

80. Orchard J, Ibbotson R, Davis Z, et al. ZAP-<br />

70 expression and prognosis in chronic<br />

lymphocytic leukemia. Lancet 2004; 363: 105-<br />

111.<br />

81. Rassenti L, Huynh L, Toy T, et al. ZAP-70<br />

compared with immunoglobulin heavy-chain<br />

gene mutation status as a predictor of disease<br />

progresión in chronic lymphocytic leucemia. N<br />

Eng J Med 2004; 351: 893-901.<br />

82. Dohner H., Stilgenbauer S, Benner A, et<br />

al. Genomic aberrations and survival in chronic<br />

lymphocytic leucemia. N Eng J Med 2000; 343:<br />

1910-1916<br />

83. Rai K, Peterson B, Appelbaum F, et al.<br />

Fludarabine compared with chlorambucil as<br />

primary therapy for chronic lymphocyic leukemia.<br />

N Eng J Med 2000; 343: 1750-1757.<br />

84. Hallek M, Schmitt B, Wihelm M, et al.<br />

Fludarabine plus cyclophosphami<strong>de</strong> is an efficient<br />

treatment for advanced chronic lymphocyic<br />

leukemia (CLL): results of a phase II study of the<br />

German CLL Study Group. Br J Haematol 2001;<br />

114: 342-348.<br />

85. Eichhorst B, Busch R, Hopfinger G, et al.<br />

Fludarabine plus cyclophosphami<strong>de</strong> (FC) induces<br />

higher remission rates and longer progression<br />

free survival (PFS) than fludarabine (F) alone in<br />

first line therapy for advanced chronic lymphocytic<br />

leukemia (CLL). Results of a Phase III study (CLL<br />

4 Protocol) of the German CLL Study Group<br />

(GCLLSG). Program and abstracts of the 45th<br />

Annual Meeting of the American Society of<br />

Haematology. December 6-9 2003; San Diego,<br />

California. Abstract 243.<br />

86. Flinn I, Kumm E, Grever M, et al.<br />

Fludarabine and cyclophosphami<strong>de</strong> produces a<br />

higher complete response rate and more durable<br />

remissions than fludarabine in patients with<br />

previously untreated CLL. Program and abstracts<br />

of the 46th Annual Meeting of the American<br />

Society of Haematology. December 4-7 2004;<br />

San Diego, California. Abstract 475.<br />

87. O´Brien S, Kantarjian H, Cortes J, et al.<br />

Results of the fludarabine and cyclophosphami<strong>de</strong><br />

combination regimen in chronic lymphocytic<br />

leukemia. J Clin Oncol 2001; 19(5): 1414-1420.<br />

88. O´Brien S, Kantarjian H., Thomas D, et al.<br />

Rituximab dose escalation trial in chronic<br />

lymphocytic leukemia. J Clin Oncol 2001; 19:<br />

2165-2170.<br />

89. Byrd J, Peterson B, Morrison V, et al.<br />

Randomizef phase 2 study of fludarabine with<br />

concurrent versus sequential treatment with<br />

rituximab in symptomatic, untreated patients<br />

woth B-cell chronic lymphocytic leukemia: results<br />

from Cancer and Leukemia Group B 9712 (CALGB<br />

9712). Blood 2003; 101: 6-14.<br />

90. Byrd J, Rai K, Peterson B, et al. Addition<br />

of rituximab to fludarabine may prolong<br />

progression free survival and overall survival in<br />

patients with previously untreated chronic<br />

lymphocytic leukemia: an updated retrospective<br />

comparative analysis of CALG 9712 and CALG<br />

9011. Blood 2005; 105: 49-53.<br />

91. Keating M, O´Brien S, Albitar M, et al.<br />

Early results of a chemoimmunotherapy regimen<br />

of fludarabine, cyclophosphami<strong>de</strong> and rituximab<br />

as initial therapy for chronic lymphocytic<br />

leukemia. J Clin Oncol 2005; 23: 4079-4088.<br />

92. Keating M, Flinn I, Jain V, et al. Therapeutic<br />

role of alentuzumab (Campath 1H) in patients<br />

who have failed fludarabine: results of a large<br />

international study. Blood 2002; 99: 3554-3561.<br />

93. Moreton P, Kwnnwsy B, Lucas G, et al.<br />

Erradication of minimal residual disease in B-cell<br />

chronic lymphocytic luekemia after alemtuzumab<br />

therapy is associated with prolonged survival. J<br />

Clin Oncol 2005; 23: 2971-2979.<br />

94. Mortillo M, Te<strong>de</strong>schi A, Rossi V, et al.<br />

Alentuzumab as consolidation after a response<br />

to fludarabine is effective to purge residual<br />

disease in patients with chronic lymphocytic<br />

leukemia. Program and abstracts of the 46th

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!