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La maladie c? - Faculté de médecine de Montpellier

La maladie c? - Faculté de médecine de Montpellier

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Master 1 Biologie santé – Immunopathologie – <strong>maladie</strong> cœliaque Année Universitaire 2010 - 2011<br />

3-3 Réponse B<br />

Help <strong>de</strong>s T CD4+ spécifiques <strong>de</strong> la gliadine<br />

Ac anti-<br />

gliadine<br />

néoépitopes Tgase-gliadine<br />

transglutaminase<br />

= dérive épitopique<br />

Sollid LM, Nat Clin Pract Gastroenterol Hepatol. 2005 Mar;2(3):140-7.<br />

Interaction Gliadin-specific T cell / TG2 specific B cell<br />

Anti- gliadine<br />

Anti- tTG<br />

Sollid LM et al. Curr Opin Immunol. 2005 Dec;17(6):595-600<br />

Dérive épitopique<br />

(epitope spreading)<br />

T. VINCENT<br />

(Mise ligne 21/03/11 – LIPCOM)<br />

<strong>Faculté</strong> <strong>de</strong> Mé<strong>de</strong>cine <strong>Montpellier</strong>-Nîmes

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