40ПРОБА КУРЦРОКА-МЮЛЛЕРА СРЕДИ ПАР, ЗАРАЖЕННЫХИНФЕКЦИЯМИ ГЕНИТАЛИЙШ. Чиокадзе, Г. ГалдаваДОМ ЗДОРОВЬЯ, КЛИНИКО-ДИАГНОСТИЧЕСКАЯ ЛАБОРАТОРИЯАНДРОЛОГИЧЕСКИЙ ОТДЕЛ НАУЧНО-ИССЛЕДОВАТЕЛЬСКОГО ИНСТИТУТАКОЖНЫХ И ВЕНЕРИЧЕСКИХ ЗАБОЛЕВАНИЙ,МЕДИЦИНСКИЙ ФАКУЛЬТЕТ ТБИЛИССКОГО ГОСУДАРСТВЕННОГОУНИВЕРСИТЕТА ИМ. ИВ.ДЖАВАХИШВИЛИУстановлена способность сперматозоидов к пенетрации в цервикальную слизь при инфекционновоспалительныхпроцессах в генитальных органах, а также нарушения концентрации антиспермальныхантител (АСА) в крови. У бесплодных мужчин с патологией, передаваемой половым путем, особеннохламидными и уреаплазмными инфекциями и простатовезикулитом, положительная проба Курцрока-Мюллера выявлена в 31,3% случаев, отрицательная – в 27,7%, сомнительная – в 41%. Адекватнаяэтиотропная терапия обеспечивает ликвидацию инфекционно-воспалительных процессов и нормализациюконцентрации антиспермальных антител в крови, со значительным улучшением способности к пенетрациисперматозоидов в цервикальное содержимое: положительная проба Курцрока-Мюллера выявлена в 83,1%случаев, сомнительная – в 13,3%, а отрицательная - в 3,6% случаев.Для усовершенствования исследования необходимо определение в цервикальном содержимом АСА,антифосфолипидных и антиядерных антител.ABILITY TO PENETRATE CERVICAL MUCUS SHOWN BYSPERMATOZOIDS OF MEN INFECTED WITH EXCRETORY-TOXICAND IMMUNE FORMS OF INFERTILITYSh. Tchiokadze, G.GaldavaDuring the control over spermatozoid penetration capacity we came across the following pictures: whenspermatozoids entered mucus <strong>of</strong> cervix uteri, they moved freely and sometimes even returned back - weconsidered it Kurzrock-Mueller positive reaction, when spermatozoids entered cervix uteri and acquired pathologicalmovement or totally stopped movement - we considered the case <strong>of</strong> doubtful reaction <strong>of</strong> Kurzrock-Mueller, and when spermatozoids could not manage to penetrate into cervical mucus and stayed on the linedividing sperm and mucus – Kurzrock-Mueller reaction was considered negative.The studies proved, that penetration <strong>of</strong> male spermatozoids suffering from the above stated pathologies <strong>of</strong>urogenital system during in vitro method, in 23(27,7%), cases was negative, in 26(31,3%) – positive, while34(41%). in Kurzrock-Mueller tests were doubtful.As a result <strong>of</strong> the adequate, anti-inflammatory medical therapy when the infectious-inflammatory pathologieswere extirpated in sex partners and when normalization <strong>of</strong> ASA concentration was achieved, penetrationability <strong>of</strong> spermatozoids into cervical matter markedly improved. We obtained the following picture: Kurzrock-Mueller positive test reached 69(83,1%), doubtful – 11(13,3%), negative –3(3,6%)..For adequate evaluation <strong>of</strong> immuno-biological processes <strong>of</strong> infertile couples it is necessary to determine thevalues <strong>of</strong> ASA, anti-phospholipid antibodies and other parameters in cervical mucus.
41literatura:1. Александров В.П., Михайличенко В.В.// Урология и андрология. Справочник для врачей.Москва - Санкт-Петербург.: СОВА 2005. – 574 с.2. Мавров И. И Половые Болезни. Москва.: АСТ-Пресс Книга 2002. -752 с.3. Choudhury SR., Knapp LA. Human reproductive failure I: immunological factors. Human ReproductionUpdate. 7(2):113-134, 2001 Mar-Apr.4. Clayton R., Moore H. Department <strong>of</strong> Molecular Biology & Biotechnology, University <strong>of</strong> Sheffield, UKExperimental models to investigate the pathology <strong>of</strong> antisperm antibodies: approaches and problems. HumanReproduction Update. 7(5):457-459, 2001 Sep-Oct.5. Eggert-Kruse W. Rohr G. Probst S. Rusu R. Hund M. Demirakca T. Aufenanger J. Runnebaum B.Petzoldt D. Department <strong>of</strong> Gynecological Endocrinology and Reproductive Medicine, Women’s Hospital Heidelberg,Germany. Antisperm antibodies and microorganisms in genital secretions—a clinically significant relationship?.Andrologia. 30 Suppl 1:61-171, 1998.6. Ghazeeri GS., Kutteh WH. Department <strong>of</strong> Obstetrics and Gynecology, University <strong>of</strong> Tennessee <strong>Medical</strong>Center, Memphis, USA. Autoimmune factors in reproductive failure. Current Opinion in Obstetrics &Gynecology. 13(3):287-291, 2001 Jun.7. Kamada M., Maegawa M., Yan YC., Koide SS., Aono T. Department <strong>of</strong> Obstetrics and Gynecology,University <strong>of</strong> Tokushima School <strong>of</strong> Medicine, Japan. Antisperm antibody: a monkey wrench in conception/magic bullet <strong>of</strong> contraception?. <strong>Journal</strong> <strong>of</strong> <strong>Medical</strong> Investigation. 46(1-2):19-28, 1999 Feb.8. Kapoor A., Talib VH., Verma SK. Department <strong>of</strong> Laboratory Medicine, Safdarjung Hospital, NewDelhi. Immunological assessment <strong>of</strong> infertility by estimation <strong>of</strong> antisperm antibodies in infertile couples. Indian<strong>Journal</strong> <strong>of</strong> Pathology & Microbiology. 42(1):37-43, 1999 Jan.9. Lombardo F., Gandini L., Dondero F., Lenzi A. Department <strong>of</strong> <strong>Medical</strong> Physiopathology, University<strong>of</strong> Rome La Sapienza, Italy. Antisperm immunity in natural and assisted reproduction. Human ReproductionUpdate. 7(5):450-456, 2001 Sep-Oct.10. Munuce MJ., Bregni C., Carizza C., Mendeluk G. Facultad de Farmacia y Bioquimica, Universidadde Buenos Aires y Medicina Reproductiva, Rosario, Argentina. Semen culture, leukocytospermia, and thepresence <strong>of</strong> sperm antibodies in seminal hyperviscosity. Archives <strong>of</strong> Andrology. 42(1):21-28, 1999 Jan-Feb.11. WHO laboratory manual for the examination <strong>of</strong> human semen and sperm-cervical mucus interaction.WHO. Third Edition 1992; p. 107 -108
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