42kvlevis mizania msxvili nawlavis fekalisda Camonarecxi wylebis gamokvleulimikrobuli struqturis Tvisobrivi daraodenobrivi monacemebis safuZvelzedisbaqteriozis arsebobisa da misi xarisxisdadgena iseTi kuW-nawlavis traqtisqronikuli paTologiis dros, rogoricaaqronikuli kataruli koliti da gaRizianebulimsxvili nawlavis sindromi.kvlevis masala da meTodebi. ambulatoriulmkurnalobaze my<strong>of</strong>i pacientebisaganklinikuri diagnoziT _ qronikulikataruli koliti da gaRizianebuli msxvilinawlavis sindromi paTologiurimasalis baqteriuli kvlevis Sedegebisgaanalizeba.mikroorganizmebis identifikacia dabiologiuri Tvisebebis Seswavla xdebodaklasikur baqteriologiur meTodebzedayrdnobiT (7-9). mxvili nawlavis mikr<strong>of</strong>lorisTvisobrivi da raodenobrivi kvlevatardeboda saTanado meTodurirekomendaciebis mixedviT (10-13).kvlevis Sedegebi da maTi ganxilva. 96pacientis gamokvlevisas, romelTachqondaT dasmuli klinikuri diagnoziqronikulikataruli koliti, pirvelixarisxis nawlavis disbaqteriozi gamouvlinda56 pirs (58,33 ±5,03%), xolo meorexarisxis - 40-s (41,67±5,03%) (diagrama 1).aRsaniSnavia, rom kvlevis masalis Segrovebisperiodi daemTxva Cvens qveyana-Si rTul socialur-ekonomikur pirobebs,amitom mogvixda met-naklebad aratradiciuliasakobrivi jgufebis daxarisxeba:17-dan 40 wlamde; 40-dan 65 wlamde da 65-dan 79 wlamde; gamokvlevas eqvemdebarebodnen,orive sqesis pirebi: 54 mdedrobi-Ti da 42 mamrobiTi. asakis mixedviT Semdemikrobiologiamikrobiocenozi qronikuli kataruli kolitiTada msxvili nawlavis sindromiT daavadebulebSim. sinjikaSviliTbilisis saxelmwifo <strong>samedicino</strong> universiteti,mikrobioloogiisa da imunoloogiis deparatamenti(recenzenti _ pr<strong>of</strong>esori m. CijavaZe)TiToeuli adamianisaTvis damaxasiaTebeliaTavisi mikrobiologiuri fenotipi,romelic formirdeba memkvidruli daaramemkvidruli cvalebadobis sxvadasxvafaqtoris zegavleniT (1,2,3). mikro- da makroorganizmis mudmivi urTierTqmedebisprocesSi formirdeba unikaluri ekosistema,romelic dinamikuri wonasworobismdgomareobaSia. adamianis msxvili nawlavismikrobiocenozi normaSi da qronikulianTebiTi daavadebis dros asaxavs aseTiurTierTqmedebis Taviseburebebs. kuWnawlavistraqtis qronikuli daavadebebimniSvnelovan xvedriT wils ikavebs avadobissaerTo struqturaSi da, mkurnalobisarsebuli meTodebis siuxvis miuxedavad,mainc avlens zrdisadmi aSkara tendencias.es, udavod, dakavSirebuli unda iyosdisbaqteriozis problemasTan, romelicSeiZleba warmoadgendes rogorc mizezs,aseve gamosavals im anTebiTi procesebisa,romelic azianebs kuW-nawlavis traqtis amaTu im monakveTs, ris gamoc kuW-nawlavistraqtis mkurnaloba disbaqteriozis koreqciisgareSe saeWvoa da arasakmarisadSedegiani (4,6).zemoTqmulidan gamomdinare didi mniSvnelobaunda mieniWos nawlavTa pa-Tologiis dros, pirvel rigSi ki qronikuladmimdinare procesebis fonze nawlavismikrobiologiur Sefasebas da masSi dar-Rvevebis arsebobis dadgenis SemTxvevaSidrouli koreqciis Catarebis aucileblobas.ZiriTadi daavadebis mkurnalobis efeqturobiszrdis mizniT, miT ufrosaqarTveloSi, sadac kuW-nawlavis traqtissxvadasxva nozologiuri formis daavadebebisda maTTan dakavSirebuli disbaqteriozisproblema metad aqtualuria.
4341,6758,33fekalur mikr<strong>of</strong>loraSi mWidrod iyodakavSirebuli daavadebis mimdinareobissimZimeze, ase magaliTad, Cvens SemTxveva-Si klinikuri mimdinareobis mixedviTdafiqsirda Semdegi suraTi: iolad mimdinarepirveli xarisxis disbaqteriozi (d.I) daufiqsirda 29 avadmy<strong>of</strong>s, I I xarisxis (d.I I ) _ 18 avadmy<strong>of</strong>s, saSualo simZimiT mimdinareI xarisxis disbaqteriozi (d I) Sesabamisad_ 22 avadmy<strong>of</strong>s, xolo I I xarisxisdisbaqteriozi _ 15 avadmy<strong>of</strong>s. pirvelixarisxis disbaqteriozi, romelic xasiaTdebodamZime mimdinareobiT, daudginda 5 pacients,xolo meore xarisxis _ 7 avadmy<strong>of</strong>s.upiratesad msxvili nawlavis dazianebisdros aRiniSneboda bifido- da laqtobaqteriebisraodenobis Semcireba 10 5 kwe/grmde,gamoy<strong>of</strong>is sixSire ki Sesabamisad udrida80,66±2,94% da 72,30±3,20% da adgilihqonda laqtozanegatiuri nawlavis Cxirebisada hemolizuri nawlavis Cxirebisraodenobis zrdas, Sesabamisad 19,05±3,24%da 17,25±3,32%-mde, gamoy<strong>of</strong>is sixSire ki Sesabamisadudrida 54,42±4,11% da 36,64±4,21%,upiratesad wvrili nawlavis dazianebis drosbifidobaqteriebis raodenoba Semcirebuliiyo 10 4 kwe/gr-mde, laqtobaqteriebis _ 10 5kwe/gr-mde. gamoy<strong>of</strong>is sixSire udrida85,64±2,61% da 70,76±3,26% Sesabamisad.agreTve, aRiniSneboda laqtozanegatiurinawlavis Cxirebisa da hemolizuri nawlavisCxirebis raodenobis mateba, Sesabamisad12,24±2,70% da 25,95±3,83%-mde. gamoy<strong>of</strong>issixSire udrida 46,26±4,11% da 35,11±4,17 %,rac Seexeba cvlilebebs, fakultaturijgufis warmomadgeneli mikroorganizmebismxriv, unda aRiniSnos, rom cvlilebebi maT-Si iyo praqtikulad erTnairi, miuxedavad imisa,Tu nawlavis traqtis romeli nawili iyodazianebuli. gamokvleuli iyo, agreTve, 107avadmy<strong>of</strong>i, romlebsac hqondaT dasmuliklinikuri diagnozi -gaRizianebuli msxvilinawlavis sindromi. 107 gamokvleuli piridan72 iyo qali, maT Soris 17-40 wlis asakSi 17piri, 40-65 wlis asakSi _ 31, xolo 65-69 wlisasakSi _ 24. literaturis monacemebiT (14-15),es paTologia erT-erTi yvelaze xSiria kuWnawlavistraqtis paTologiis struqturaSida Seadgens kuW-nawlavis paTologiis 15%-s,qalTa populaciaSi 2-3-jer xSiria, vidre mamakacebSida eqimTa mimarTvis 50%-s Seadgens.am daavadebis paTogenezi SeiZleba aixsnaskuW-nawlavis traqtSi gluvkunTovaniujredebis defeqtiT an neirohumoruliregulaciis moSliT.Cven mier Catarebuli baqteriuli gamokvlevevisSedegad dadginda, rom am jgufis pacientebSipraqtikulad yvelas gamouvlindiagrama1. qronikuli kataruli kolitiTdaavadebuli 96 piris nawlavisdisbaqteriozis xarisxis procentulimaCvenebliI xarisxis disbaqteriozi - 56 avadmy<strong>of</strong>i(58,33±5,03%)II xarisxis disbaqteriozi - 40 avadmy<strong>of</strong>i(41,67 ±5,03%)filokoki, enterokoki, sokoebi da sxva)warmomadgenlebis raodenobis mateba. asemagaliTad, bifidobaqteriebis raodenoba10 2 -10 5 kwe/gr) aRmoaCnda avadmy<strong>of</strong>Ta70,83±4,64%-s (68 piri), gamoy<strong>of</strong>is six-Sirem ki Seadgina 81,22± 2,90%, laqtobaqteriebisraodenoba 10 2 10 5 kwe/gr aRmoaCnda66 avadmy<strong>of</strong>s, anu 68,75±4,73%-s,gamoy<strong>of</strong>is sixSire ki udrida 85,13±2,55%.hemolizuri da laqtozanegatiuri nawlavisCxirebi 20,28±1,81%-Si (nawlavis CxirebissaerTo raodenobidan gamouvlindaavadmy<strong>of</strong>Ta 40,63±5,01%-s (39 avadmy<strong>of</strong>i),gamoy<strong>of</strong>is sixSirem ki Seadgina62,60±2,23%. rac Seexeba fakultaturijgufis warmomadgenlobas, maTi raodenobiszrdas erTi-orjer adgili hqondaavadmy<strong>of</strong>Ta 22,94±4,29%-Si (22 piri),gamoy<strong>of</strong>is sixSire ki iyo 18 %-dan 34%-isfarglebSi.aRsaniSnavia, rom qronikuli katarulikolitiT daavadebul pirebSi cvlilebebigi suraTi gamoixata: 17-40 weli (19 qali, 40mamakaci), 40-65 weli (22 qali, 16 mamakaci),65-79 weli (13 qali, 14 mamakaci).qronikuli kataruli kolitiT daavadebuli96 piris fekaliebis baqteriologiurigamokvleviT dadginda bifido-da laqtobaqteriebis gamoy<strong>of</strong>is six-Sirisa da raodenobis daqveiTeba da amisfonze fermentulad daqveiTebuli dahemolizuri Tvisebebis mqone nawlavisCxirebis raodenobis zrda da asevefakultaturi jgufis (proteusi, sta-