Products at a Glance 2024

www.pelobiotech.com 4.

www.pelobiotech.com 4. Detailed Donor Information: We offer in-depth donor information, including gender, age, ethnicity, BMI, cause of death, smoking and alcohol history, HLA typing, serology data, and past medical records, allowing you to choose cells that align with your specific research requirements. 5. Versatility in Testing: Our hepatocytes are not only plateable but also 3D tested, offering versatility for various research applications, from monolayer cultures to complex 3D experiments. Please contact us for detailed information about 3D cell culture to find out how we can help you better. Explore the intricate and vital role of hepatocytes in the human body's metabolism of xenobiotics and drugs by reading our article on our News section on website for in-depth information. Just scan the QR code for direct access. Scan the QR code to see our full cell list. Fibroblasts contribute to studies on liver fibrosis and tissue repair, shedding light on the cellular dynamics in hepatic wound healing. Kupffer cells, as liver-resident macrophages, are key players in immune response studies, inflammation, and liver pathophysiology. Stellate cells, involved in liver fibrosis, are integral for investigations into hepatic stellate cell activation and its impact on liver health. Hematopoietic stem cells extracted from the liver provide a unique perspective on hematopoiesis and immune cell development. Non-parenchymal cells, comprising various liver cell types, enable comprehensive studies encompassing liver microenvironment, cell-to-cell interactions, and organ-specific responses to therapeutic interventions. Stellate cells, also known as hepatic stellate cells, play a significant role in liver fibrosis, and their activation is a key event in the development of fibrosis. They are involved in the resolution of liver injury and are the primary storage site for retinoids in the liver. Additionally, stellate cells have been shown to express desmin, suggesting their contribution to the stellate cell population. Furthermore, stellate cells have been implicated in the regulation of liver fibrosis and have been shown to produce increased levels of inflammatory mediators, contributing to the fibrogenic program of liver cells. They are also involved in the turnover of extracellular matrix, and their activation is a major pathogenic determinant of liver fibrosis. Moreover, stellate cells have been shown to be coupled to one another by gap junctions, indicating their role in intercellular communication. Additionally, stellate cells have been studied in the context of liver regeneration, and their inhibition has been shown to reduce renal fibrosis. Kupffer cells, which are liver-resident macrophages, play a crucial role in liver homeostasis, inflammation, and immune regulation. They have been implicated in the pathogenesis of wound healing and fibrosis in the liver. Kupffer cells have been shown to be involved in the regulation of stellate cell activation and susceptibility to fibrotic liver disease. Sinusoidal microvascular endothelial cells, which line the hepatic sinusoids, have been studied for their involvement in liver fibrogenesis and the resolution of liver injury. They have been shown to be regulated by vitamin A and retinoic acid signaling, which are essential for their development and liver morphogenesis. Endothelin antagonism has been studied in the context of hepatic fibrosis, implicating endothelial cells in the pathogenesis of wound healing and fibrosis. 20

www.pelobiotech.com Eyes We isolate retinal pigment cells, endothelial cells, cryopreserved CnCePc, RbCEpCs, keratinocytes, meshwork cells, retinal astrocytes, and various immortalized pericytes from the eyes. These samples are sourced from various species and various regions and vessels of the eye. Retinal pigment epithelial (RPE) cells play a crucial role in maintaining retinal homeostasis and visual function. They have been extensively studied for their involvement in retinal diseases, such as age-related macular degeneration (AMD), and have been used to model retinal pathologies in vitro. RPE cells have been shown to be involved in the regulation of the blood-retinal barrier (BRB) and have been used to establish cell lines and study transport functions across the inner BRB. Additionally, RPE cells have been implicated in the transfer of melanosomes to keratinocytes, contributing to skin pigmentation and melanosome distribution. Furthermore, RPE cells have been studied for their involvement in the pathogenesis of diabetic retinopathy and have been used to establish a human retinal pericyte line, providing a novel tool for the study of diabetic retinopathy. Endothelial cells have been extensively studied for their role in angiogenesis, blood-brain barrier (BBB) function, and the regulation of vascular permeability. They have been used to establish cell lines and study the formation and disruption of the BBB, providing insights into CNS homeostasis and the pathogenesis of neurological disorders. Endothelial cells have been implicated in the regulation of the blood-nerve barrier (BNB) and have been used to establish a new in vitro BNB model, contributing to the study of peripheral neuropathy and peripheral nerve function. Cryopreserved corneal endothelial precursor cells (CnCePc) and retinal endothelial cells (RbCEpCs) have been studied for their potential in corneal and retinal tissue engineering and regenerative medicine. They have been used to establish cell lines and study the expression of wound-healing-related genes in primary human keratinocytes from burn patients, providing insights into the potential therapeutic applications of these cells in wound healing and tissue regeneration. Keratinocytes have been extensively studied for their role in skin pigmentation, wound healing, and skin regenerative applications. They have been used to study melanosome transfer, phagocytic activity, and the distribution pattern of melanosomes, shedding light on their role in skin pigmentation and melanosome transfer to keratinocytes. Keratinocytes have been used to establish a new immortalized human lung pericyte cell line, providing a promising tool for human lung pericyte studies and contributing to the study of lung pericyte functions in vitro. Meshwork cells, also known as trabecular meshwork, have been studied for their involvement in glaucoma and aqueous humor outflow regulation. They have been used to study the regulation of extracellular-superoxide dismutase and have been implicated in the regulation of L-arginine transport in retinal pericytes, providing insights into their role in retinal pericyte function and oxidative stress regulation. Retinal astrocytes have been studied for their involvement in neuroinflammation and the blood-brain barrier (BBB). They have been used to identify distinct contributions of astrocytes and pericytes to neuroinflammation and have been implicated in the regulation of the blood-brain barrier (BBB) and the maintenance of CNS homeostasis. Immortalized pericytes have been extensively studied for their involvement in the blood-brain barrier (BBB), retinal pericyte function, and the regulation of L-arginine transport. They have been used to study the expression of rat ABCG2 on the luminal side of brain capillaries and have been implicated in the regulation of L-arginine transport in retinal pericytes, providing insights into their role in retinal pericyte function and the blood-brain barrier (BBB). Lymphatic system We provide fibroblasts and endothelial cells from various vessels of the lymphatic system in different animal species. Fibroblasts have been studied for their potential role in promoting lymphangiogenesis in head and neck neoplasms, providing insight into the pathways leading to lymphatic vessel formation in each patient. Fibroblasts surrounding cystic lymphatics have been found to induce the expression of Amphiregulin in lymphatic endothelial cells, suggesting their involvement in the pathogenesis of cystic lymphangioma. Cancer-associated fibroblasts have been shown to promote 21