Allgemeine Toxikologie II - Institut für Analytische Chemie

PAH - DNA Adducts* in leucocytes
of exposed persons (Schlesien)
Adducts/10
30
8 Nukleotides
20
10
( * 32 P-postlabelling)
0
Coken oven
Controls
workers Close to plant rural
µg PAH / m³ Air: 0,1-50 0,057-0,01
(Jan. - Mai)
no data
(Hemminki et al., Carcinog., 11(7), 1990)
Genotoxic activity of B(a)P, B(a)A und DBA
in short-term assays
Mutagenicity in bacteria
Chromosomal aberrations
in mammalia
Micronucleus test
DNA-binding
DNA-repair
in target tissue
Chromosomal aberrations in
exposed persons
IARC, Vol. 3, 1973; Vol. 32, 1983
in vitro
in vitro
in vivo
in vivo
in vitro
in vivo
In vitro
in vivo
B(a)P
B(a)P, Benz(a)pyrene; B(a)A,Benzanthracene; DBA: Dibenzanthracene
+
+
+
+
+
+
+
+
+
B(a)A
+
+
+
+
+
+
DBA
+
+
+
+
+
49
50
25